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Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.

BACKGROUNDBococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODSIn two paral... Full description

Journal Title: The New England journal of medicine April 20, 2017, Vol.376(16), pp.1527-1539
Main Author: Ridker, Paul M
Other Authors: Revkin, James , Amarenco, Pierre , Brunell, Robert , Curto, Madelyn , Civeira, Fernando , Flather, Marcus , Glynn, Robert J , Gregoire, Jean , Jukema, J Wouter , Karpov, Yuri , Kastelein, John J P , Koenig, Wolfgang , Lorenzatti, Alberto , Manga, Pravin , Masiukiewicz, Urszula , Miller, Michael , Mosterd, Arend , Murin, Jan , Nicolau, Jose C , Nissen, Steven , Ponikowski, Piotr , Santos, Raul D , Schwartz, Pamela F , Soran, Handrean , White, Harvey , Wright, R Scott , Vrablik, Michal , Yunis, Carla , Shear, Charles L , Tardif, Jean-Claude , Ridker, Paul M
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1533-4406 ; DOI: 10.1056/NEJMoa1701488
Link: http://search.proquest.com/docview/1878827356/?pq-origsite=primo
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title: Cardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
format: Article
creator:
  • Ridker, Paul M
  • Revkin, James
  • Amarenco, Pierre
  • Brunell, Robert
  • Curto, Madelyn
  • Civeira, Fernando
  • Flather, Marcus
  • Glynn, Robert J
  • Gregoire, Jean
  • Jukema, J Wouter
  • Karpov, Yuri
  • Kastelein, John J P
  • Koenig, Wolfgang
  • Lorenzatti, Alberto
  • Manga, Pravin
  • Masiukiewicz, Urszula
  • Miller, Michael
  • Mosterd, Arend
  • Murin, Jan
  • Nicolau, Jose C
  • Nissen, Steven
  • Ponikowski, Piotr
  • Santos, Raul D
  • Schwartz, Pamela F
  • Soran, Handrean
  • White, Harvey
  • Wright, R Scott
  • Vrablik, Michal
  • Yunis, Carla
  • Shear, Charles L
  • Tardif, Jean-Claude
  • Ridker, Paul M
subjects:
  • Antibodies–Blood
  • Antibodies, Monoclonal, Humanized–Adverse Effects
  • Anticholesteremic Agents–Immunology
  • Cardiovascular Diseases–Therapeutic Use
  • Cholesterol, LDL–Adverse Effects
  • Double-Blind Method–Immunology
  • Female–Therapeutic Use
  • Follow-Up Studies–Prevention & Control
  • Humans–Blood
  • Hypercholesterolemia–Drug Therapy
  • Injections, Subcutaneous–Adverse Effects
  • Lipids–Blood
  • Male–Antagonists & Inhibitors
  • Middle Aged–Immunology
  • Proprotein Convertase 9–Immunology
  • Risk Factors–Immunology
  • Treatment Failure–Immunology
  • Abridged
  • Antibodies
  • Antibodies, Monoclonal, Humanized
  • Anticholesteremic Agents
  • Cholesterol, LDL
  • Lipids
  • Bococizumab
  • Pcsk9 Protein, Human
  • Proprotein Convertase 9
ispartof: The New England journal of medicine, April 20, 2017, Vol.376(16), pp.1527-1539
description: BACKGROUNDBococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODSIn two parallel,...
language: eng
source:
identifier: E-ISSN: 1533-4406 ; DOI: 10.1056/NEJMoa1701488
fulltext: fulltext
issn:
  • 15334406
  • 1533-4406
url: Link


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titleCardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
creatorRidker, Paul M ; Revkin, James ; Amarenco, Pierre ; Brunell, Robert ; Curto, Madelyn ; Civeira, Fernando ; Flather, Marcus ; Glynn, Robert J ; Gregoire, Jean ; Jukema, J Wouter ; Karpov, Yuri ; Kastelein, John J P ; Koenig, Wolfgang ; Lorenzatti, Alberto ; Manga, Pravin ; Masiukiewicz, Urszula ; Miller, Michael ; Mosterd, Arend ; Murin, Jan ; Nicolau, Jose C ; Nissen, Steven ; Ponikowski, Piotr ; Santos, Raul D ; Schwartz, Pamela F ; Soran, Handrean ; White, Harvey ; Wright, R Scott ; Vrablik, Michal ; Yunis, Carla ; Shear, Charles L ; Tardif, Jean-Claude ; Ridker, Paul M
contributorConde, Diego (correspondence author) ; Colquhoun, David (record owner) ; Missault, Luc ; Grégoire, Jean ; Gao, Runlin ; Urina, Miguel ; Solar, Miroslav ; Jensen, Henrik Kjaerulf ; Grobbee, Diederick ; Savolainen, Markku ; Schiele, François ; Montalescot, Gilles ; Edes, Istvan ; Blake, Gavin ; Lotan, Chaim ; Maggioni, Aldo ; Savonitto, Stefano ; Lee, Cheol Whan ; Leiva Pons, Jose Luis ; Dan, Gheorghe-Andrei ; Cortada, Jordi Bruguera ; Mellbin, Linda ; Kahan, Thomas ; Noble, Stephane ; Hwang, Juey-Jen ; Sritara, Piyamitr ; Tökgozoğlu, Lale ; Tarasenko, Lisa ; Borer, Jeffrey S ; Black, Henry ; Carmena, Rafael ; Furie, Karen L ; Mcmurray, John ; Neaton, James ; Zannad, Faiez ; O’neill, Blair ; Welty, Francine ; Mcnamara, Robert ; Chun, Hyung ; Abbott, J Dawn ; Jacoby, Daniel ; Mcpherson, Craig ; Jadbabaie, Farid ; Pinto, Duane ; Mccullough, Louise ; Silverman, Isaac E ; Sansing, Lauren H ; Dearborn-Tomazos, Jennifer ; Foody, Joanne ; Schindler, Joseph ; Piazza, Gregory ; Chakrabarti, Anjan ; Pride, Yuri ; Gelfand, Eli ; Baultrukonis, Dan ; Chaudhuri, Sandip ; Frederich, Robert ; Johnson, Margot ; Mridha, Khurshid ; Powell, Coralie ; Wang, Ellen ; Wei, Caimiao ; Anderson, Patricia ; Buonanno, Marjorie ; Epsley, Charlotte ; Evans, Barbara ; Frolova, Martina ; Goetsch, Martina ; Hessinger, Diane ; Ikehara, Edson ; Ivanac, Karen ; Kizko, Jan ; Le, Kim ; Mcnally-Dufort, Christine ; Morocco, Tamara ; Nadkarni, Sharayu ; Nissen, Thor ; Nye, Regina ; Pak, Raphael ; Pence, Debbie ; Redifer, Patricia ; Schwartz, Whitney ; Sattler, Catherine ; Schade, Robin ; Sullivan, Beth ; Wegner, John ; Alvarez, C A ; Budassi, N ; Vogel, D R ; Avaca, H ; Conde, D G ; Estol, C C C J ; Gelersztein, E ; Glenny, J A ; Hershson, A R ; Bruno, R L ; Maffei, L E ; Soler, J M P ; Zaidman, C J ; Carnero, G S ; Colombo, H R ; Jure, H O ; Luquez, H A ; Ramos, H R ; Resk, J H ; Rusculleda, M M ; Ulla, M R ; Caccavo, A ; Farias, E F ; Wenetz, L M M ; Cabella, P R F ; Cuadrado, J A ; Chahin, M ; Mackinnon, I J ; Zarandon, R B S ; Schmidberg, J ; Fernandez, A A ; Montana, O ; Codutti, O R ; Gorosito, V M ; Maldonado, N ; Sala, J ; De La Fuente, R A L ; Casabella, T E S ; Di Gennaro, J P A ; Guerrero, R A A ; Alvarez, M S ; Berli, M ; Botta, C E ; Montenegro, E E ; Vico, M L ; Begg, A ; Lehman, R ; Gilfillan, C P ; D'Emden, M ; Markovic, T P ; Sullivan, D ; Aroney, C ; Stranks, S N ; Crimmins, D S ; Arstall, M ; Van Gaal, W ; Davis, T ; Aylward, P E ; Amerena, J ; William, M ; Proietto, J ; Purnell, P W ; Singh, B ; Arya, K W ; Dart, A M ; Colquhoun, D ; Thompson, P ; Davis, S M ; Carroll, P A ; De Looze, F ; Jayasinghe, R ; Bhindi, R ; Buysschaert, I ; Sarens, T ; van de Borne, P ; Scott, B P ; Roosen, J ; Cools, F ; Missault, L H ; Debroye, C ; Schoors, D F ; Hollanders, G ; Schroe, H H ; De Sutter, J ; Hermans, K ; Carlier, M ; van Landegem, P ; Verwerft, J ; Mulleners, T ; Delforge, M D ; Soufflet, V ; Elegeert, I ; Descamps, O S ; Janssens, S ; Lemmens, R C ; Desfontaines, P ; Scheen, A ; Heijmans, S ; Capiau, L ; Vervoort, G ; Carlier, S G ; Faes, D ; Alzand, B ; Keuleers, S ; De Wolf, L ; Thoeng, J ; De Bruyne, L ; de Santos, M O N ; Felicio, J S ; Areas, C A F ; Figueiredo, E L ; Michalaros, Y L ; Neuenschwander, F C ; Reis, G ; Saad, J A ; Kormann, A P M ; Nascimento, C V ; Precoma, D B ; Abib, E ; Dos Santos, F R ; Mello, Y G ; Saraiva, J F K ; Rech, R L ; Cerci, R ; Fortes, J A R ; Rossi, P R F ; de Lima E Silva, F A ; Hissa, M ; Silva, R P ; de Souza, W K S B ; Guimarães Filho, F V ; Mangili, O C
ispartofThe New England journal of medicine, April 20, 2017, Vol.376(16), pp.1527-1539
identifierE-ISSN: 1533-4406 ; DOI: 10.1056/NEJMoa1701488
subjectAntibodies–Blood ; Antibodies, Monoclonal, Humanized–Adverse Effects ; Anticholesteremic Agents–Immunology ; Cardiovascular Diseases–Therapeutic Use ; Cholesterol, LDL–Adverse Effects ; Double-Blind Method–Immunology ; Female–Therapeutic Use ; Follow-Up Studies–Prevention & Control ; Humans–Blood ; Hypercholesterolemia–Drug Therapy ; Injections, Subcutaneous–Adverse Effects ; Lipids–Blood ; Male–Antagonists & Inhibitors ; Middle Aged–Immunology ; Proprotein Convertase 9–Immunology ; Risk Factors–Immunology ; Treatment Failure–Immunology ; Abridged ; Antibodies ; Antibodies, Monoclonal, Humanized ; Anticholesteremic Agents ; Cholesterol, LDL ; Lipids ; Bococizumab ; Pcsk9 Protein, Human ; Proprotein Convertase 9
descriptionBACKGROUNDBococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODSIn two parallel,...
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0Ridker, Paul M
1Revkin, James
2Amarenco, Pierre
3Brunell, Robert
4Curto, Madelyn
5Civeira, Fernando
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7Glynn, Robert J
8Gregoire, Jean
9Jukema, J Wouter
10Karpov, Yuri
11Kastelein, John J P
12Koenig, Wolfgang
13Lorenzatti, Alberto
14Manga, Pravin
15Masiukiewicz, Urszula
16Miller, Michael
17Mosterd, Arend
18Murin, Jan
19Nicolau, Jose C
20Nissen, Steven
21Ponikowski, Piotr
22Santos, Raul D
23Schwartz, Pamela F
24Soran, Handrean
25White, Harvey
26Wright, R Scott
27Vrablik, Michal
28Yunis, Carla
29Shear, Charles L
30Tardif, Jean-Claude
titleCardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
descriptionBACKGROUNDBococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODSIn two parallel,...
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1Antibodies, Monoclonal, Humanized–Adverse Effects
2Anticholesteremic Agents–Immunology
3Cardiovascular Diseases–Therapeutic Use
4Cholesterol, LDL–Adverse Effects
5Double-Blind Method–Immunology
6Female–Therapeutic Use
7Follow-Up Studies–Prevention & Control
8Humans–Blood
9Hypercholesterolemia–Drug...
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8Grobbee, Diederick
9Savolainen, Markku
10Schiele, François
11Montalescot, Gilles
12Edes, Istvan
13Blake, Gavin
14Lotan, Chaim
15Maggioni, Aldo
16Savonitto, Stefano
17Lee, Cheol Whan
18Leiva Pons, Jose Luis
19Dan, Gheorghe-Andrei
20Cortada, Jordi Bruguera
21Mellbin, Linda
22Kahan, Thomas
23Noble, Stephane
24Hwang, Juey-Jen
25Sritara, Piyamitr
26Tökgozoğlu, Lale
27Tarasenko, Lisa
28Borer, Jeffrey S
29Black, Henry
30Carmena, Rafael
31Furie, Karen L
32Mcmurray, John
33Neaton, James
34Zannad, Faiez
35O’neill, Blair
36Welty, Francine
37Mcnamara, Robert
38Chun, Hyung
39Abbott, J Dawn
40Jacoby, Daniel
41Mcpherson, Craig
42Jadbabaie, Farid
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79Pence, Debbie
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titleCardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
authorRidker, Paul M ; Revkin, James ; Amarenco, Pierre ; Brunell, Robert ; Curto, Madelyn ; Civeira, Fernando ; Flather, Marcus ; Glynn, Robert J ; Gregoire, Jean ; Jukema, J Wouter ; Karpov, Yuri ; Kastelein, John J P ; Koenig, Wolfgang ; Lorenzatti, Alberto ; Manga, Pravin ; Masiukiewicz, Urszula ; Miller,...
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0Antibodies–Blood
1Antibodies, Monoclonal, Humanized–Adverse Effects
2Anticholesteremic Agents–Immunology
3Cardiovascular Diseases–Therapeutic Use
4Cholesterol, LDL–Adverse Effects
5Double-Blind Method–Immunology
6Female–Therapeutic Use
7Follow-Up Studies–Prevention & Control
8Humans–Blood
9Hypercholesterolemia–Drug...
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0Ridker, Paul M
1Revkin, James
2Amarenco, Pierre
3Brunell, Robert
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7Glynn, Robert J
8Gregoire, Jean
9Jukema, J Wouter
10Karpov, Yuri
11Kastelein, John J P
12Koenig, Wolfgang
13Lorenzatti, Alberto
14Manga, Pravin
15Masiukiewicz, Urszula
16Miller, Michael
17Mosterd, Arend
18Murin, Jan
19Nicolau, Jose C
20Nissen, Steven
21Ponikowski, Piotr
22Santos, Raul D
23Schwartz, Pamela F
24Soran, Handrean
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28Yunis, Carla
29Shear, Charles L
30Tardif, Jean-Claude
31Conde, Diego
32Colquhoun, David
33Missault, Luc
34Grégoire, Jean
35Gao, Runlin
36Urina, Miguel
37Solar, Miroslav
38Jensen, Henrik Kjaerulf
39Grobbee, Diederick
40Savolainen, Markku
41Schiele, François
42Montalescot, Gilles
43Edes, Istvan
44Blake, Gavin
45Lotan, Chaim
46Maggioni, Aldo
47Savonitto, Stefano
48Lee, Cheol Whan
49Leiva Pons, Jose Luis
50Dan, Gheorghe-Andrei
51Cortada, Jordi Bruguera
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53Kahan, Thomas
54Noble, Stephane
55Hwang, Juey-Jen
56Sritara, Piyamitr
57Tökgozoğlu, Lale
58Tarasenko, Lisa
59Borer, Jeffrey S
60Black, Henry
61Carmena, Rafael
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50Piazza, Gregory
51Chakrabarti, Anjan
52Pride, Yuri
53Gelfand, Eli
54Baultrukonis, Dan
55Chaudhuri, Sandip
56Frederich, Robert
57Johnson, Margot
58Mridha, Khurshid
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60Wang, Ellen
61Wei, Caimiao
62Anderson, Patricia
63Buonanno, Marjorie
64Epsley, Charlotte
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69Ikehara, Edson
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72Le, Kim
73McNally-Dufort, Christine
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80Redifer, Patricia
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83Schade, Robin
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85Wegner, John
86Alvarez, C A
87Budassi, N
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90Conde, D G
91Estol, C C C J
92Gelersztein, E
93Glenny, J A
94Hershson, A R
95Bruno, R L
96Maffei, L E
97Soler, J M P
98Zaidman, C J
99Carnero, G S
100...
atitleCardiovascular Efficacy and Safety of Bococizumab in High-Risk Patients.
jtitleThe New England journal of medicine
risdate20170420
volume376
issue16
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abstractBACKGROUNDBococizumab is a humanized monoclonal antibody that inhibits proprotein convertase subtilisin-kexin type 9 (PCSK9) and reduces levels of low-density lipoprotein (LDL) cholesterol. We sought to evaluate the efficacy of bococizumab in patients at high cardiovascular risk. METHODSIn two parallel,...
doi10.1056/NEJMoa1701488
urlhttp://search.proquest.com/docview/1878827356/
issn00284793
date2017-04-20