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Multi-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging.

A novel single-molecular fluorescent probe was developed for spatiotemporal matrix metalloproteinase-2 (MMP-2) and caspase-3 imaging with distinct fluorescence signals. Due to the multi-Forster resonance energy transfer (FRET) processes, the probe could respond to MMP-2 and caspase-3 independently w... Full description

Journal Title: Analytical chemistry April 18, 2017, Vol.89(8), pp.4349-4354
Main Author: Cheng, Hong
Other Authors: Li, Shi-Ying , Zheng, Hao-Ran , Li, Chu-Xin , Xie, Bo-Ru , Chen, Ke-Wei , Li, Bin , Zhang, Xian-Zheng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-6882 ; DOI: 10.1021/acs.analchem.7b00277
Link: http://search.proquest.com/docview/1883839906/?pq-origsite=primo
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title: Multi-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging.
format: Article
creator:
  • Cheng, Hong
  • Li, Shi-Ying
  • Zheng, Hao-Ran
  • Li, Chu-Xin
  • Xie, Bo-Ru
  • Chen, Ke-Wei
  • Li, Bin
  • Zhang, Xian-Zheng
subjects:
  • Animals–Chemistry
  • Cos Cells–Metabolism
  • Caspase 3–Chemistry
  • Cell Line, Tumor–Chemistry
  • Cercopithecus Aethiops–Metabolism
  • Flow Cytometry–Metabolism
  • Fluorescence Resonance Energy Transfer–Metabolism
  • Fluorescent Dyes–Metabolism
  • Humans–Metabolism
  • Matrix Metalloproteinase 2–Metabolism
  • Microscopy, Confocal–Metabolism
  • Fluorescent Dyes
  • Caspase 3
  • Matrix Metalloproteinase 2
ispartof: Analytical chemistry, April 18, 2017, Vol.89(8), pp.4349-4354
description: A novel single-molecular fluorescent probe was developed for spatiotemporal matrix metalloproteinase-2 (MMP-2) and caspase-3 imaging with distinct fluorescence signals. Due to the multi-Forster resonance energy transfer (FRET) processes, the probe could respond to MMP-2 and caspase-3 independently with high signal-to-noise ratio. Moreover, the overexpression of MMP-2 in cancer cell lines and the cisplatin induced cell apoptosis were spatiotemporal imaged with distinct fluorescence emissions. Because of the independent process of the probe for MMP-2 and caspase-3 imaging, the probe could meet the demands for precise disease diagnosis and cancer theranostic applications, which could extensively simplify the processes for precise cancer diagnosis and imaging.
language: eng
source:
identifier: E-ISSN: 1520-6882 ; DOI: 10.1021/acs.analchem.7b00277
fulltext: no_fulltext
issn:
  • 15206882
  • 1520-6882
url: Link


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titleMulti-Förster Resonance Energy Transfer-Based Fluorescent Probe for Spatiotemporal Matrix Metalloproteinase-2 and Caspase-3 Imaging.
creatorCheng, Hong ; Li, Shi-Ying ; Zheng, Hao-Ran ; Li, Chu-Xin ; Xie, Bo-Ru ; Chen, Ke-Wei ; Li, Bin ; Zhang, Xian-Zheng
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identifierE-ISSN: 1520-6882 ; DOI: 10.1021/acs.analchem.7b00277
subjectAnimals–Chemistry ; Cos Cells–Metabolism ; Caspase 3–Chemistry ; Cell Line, Tumor–Chemistry ; Cercopithecus Aethiops–Metabolism ; Flow Cytometry–Metabolism ; Fluorescence Resonance Energy Transfer–Metabolism ; Fluorescent Dyes–Metabolism ; Humans–Metabolism ; Matrix Metalloproteinase 2–Metabolism ; Microscopy, Confocal–Metabolism ; Fluorescent Dyes ; Caspase 3 ; Matrix Metalloproteinase 2
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descriptionA novel single-molecular fluorescent probe was developed for spatiotemporal matrix metalloproteinase-2 (MMP-2) and caspase-3 imaging with distinct fluorescence signals. Due to the multi-Forster resonance energy transfer (FRET) processes, the probe could respond to MMP-2 and caspase-3 independently with high signal-to-noise ratio. Moreover, the overexpression of MMP-2 in cancer cell lines and the cisplatin induced cell apoptosis were spatiotemporal imaged with distinct fluorescence emissions. Because of the independent process of the probe for MMP-2 and caspase-3 imaging, the probe could meet the demands for precise disease diagnosis and cancer theranostic applications, which could extensively simplify the processes for precise cancer diagnosis and imaging.
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