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Supramolecular Photoactivatable Anticancer Hydrogels.

A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, c... Full description

Journal Title: Journal of the American Chemical Society April 26, 2017, Vol.139(16), pp.5656-5659
Main Author: Venkatesh, V
Other Authors: Mishra, Narendra Kumar , Romero-Canelón, Isolda , Vernooij, Robbin R , Shi, Huayun , Coverdale, James P C , Habtemariam, Abraha , Verma, Sandeep , Sadler, Peter J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/jacs.7b00186
Link: http://search.proquest.com/docview/1888962707/?pq-origsite=primo
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title: Supramolecular Photoactivatable Anticancer Hydrogels.
format: Article
creator:
  • Venkatesh, V
  • Mishra, Narendra Kumar
  • Romero-Canelón, Isolda
  • Vernooij, Robbin R
  • Shi, Huayun
  • Coverdale, James P C
  • Habtemariam, Abraha
  • Verma, Sandeep
  • Sadler, Peter J
subjects:
  • Antineoplastic Agents–Chemistry
  • Borates–Pharmacology
  • Cell Line–Chemistry
  • Cell Proliferation–Pharmacology
  • Cell Survival–Drug Effects
  • Cisplatin–Drug Effects
  • Dopamine–Chemistry
  • Dose-Response Relationship, Drug–Pharmacology
  • Drug Screening Assays, Antitumor–Chemistry
  • Fibroblasts–Pharmacology
  • Humans–Drug Effects
  • Hydrogels–Chemistry
  • Macromolecular Substances–Pharmacology
  • Molecular Structure–Chemistry
  • Organoplatinum Compounds–Pharmacology
  • Particle Size–Chemistry
  • Photochemical Processes–Pharmacology
  • Structure-Activity Relationship–Pharmacology
  • Surface Properties–Pharmacology
  • Antineoplastic Agents
  • Borates
  • Hydrogels
  • Macromolecular Substances
  • Organoplatinum Compounds
  • Cisplatin
  • Dopamine
ispartof: Journal of the American Chemical Society, April 26, 2017, Vol.139(16), pp.5656-5659
description: A photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 μM, blue light) with a photocytotoxic index 5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).
language: eng
source:
identifier: E-ISSN: 1520-5126 ; DOI: 1520-5126 ; DOI: 10.1021/jacs.7b00186
fulltext: no_fulltext
issn:
  • 15205126
  • 1520-5126
url: Link


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titleSupramolecular Photoactivatable Anticancer Hydrogels.
creatorVenkatesh, V ; Mishra, Narendra Kumar ; Romero-Canelón, Isolda ; Vernooij, Robbin R ; Shi, Huayun ; Coverdale, James P C ; Habtemariam, Abraha ; Verma, Sandeep ; Sadler, Peter J
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subjectAntineoplastic Agents–Chemistry ; Borates–Pharmacology ; Cell Line–Chemistry ; Cell Proliferation–Pharmacology ; Cell Survival–Drug Effects ; Cisplatin–Drug Effects ; Dopamine–Chemistry ; Dose-Response Relationship, Drug–Pharmacology ; Drug Screening Assays, Antitumor–Chemistry ; Fibroblasts–Pharmacology ; Humans–Drug Effects ; Hydrogels–Chemistry ; Macromolecular Substances–Pharmacology ; Molecular Structure–Chemistry ; Organoplatinum Compounds–Pharmacology ; Particle Size–Chemistry ; Photochemical Processes–Pharmacology ; Structure-Activity Relationship–Pharmacology ; Surface Properties–Pharmacology ; Antineoplastic Agents ; Borates ; Hydrogels ; Macromolecular Substances ; Organoplatinum Compounds ; Cisplatin ; Dopamine
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descriptionA photoactivatable dopamine-conjugated platinum(IV) anticancer complex (Pt-DA) has been incorporated into G-quadruplex G4K+ borate hydrogels by using borate ester linkages (Pt-G4K+B hydrogel). These were characterized by 11B NMR, attenuated total reflection Fourier transform infrared spectroscopy, circular dichroism, scanning electron microscopy and transmission electron microscopy. Microscopy investigations revealed the transformation of an extended fiber assembly into discrete flakes after incorporation of Pt-DA. Pt-DA showed photocytotoxicity against cisplatin-resistant A2780Cis human ovarian cancer cells (IC50 74 μM, blue light) with a photocytotoxic index <2, whereas Pt-G4K+B hydrogels exhibited more potent photocytotoxicity (IC50 3 μM, blue light) with a photocytotoxic index >5. Most notably, Pt-DA and Pt-G4K+B hydrogels show selective phototoxicity for cancer cells versus normal fibroblast cells (MRC5).
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