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Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis.

BACKGROUNDThere are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radio... Full description

Journal Title: Oncotarget April 25, 2017, Vol.8(17), pp.28215-28225
Main Author: Huang, Xuan-Zhang
Other Authors: Chen, You , Chen, Wen-Jun , Zhang, Xi , Wu, Cong-Cong , Zhang, Chao-Ying , Sun, Shuang-Shuang , Wu, Jian
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.15998
Link: http://search.proquest.com/docview/1889384603/?pq-origsite=primo
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title: Effect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis.
format: Article
creator:
  • Huang, Xuan-Zhang
  • Chen, You
  • Chen, Wen-Jun
  • Zhang, Xi
  • Wu, Cong-Cong
  • Zhang, Chao-Ying
  • Sun, Shuang-Shuang
  • Wu, Jian
subjects:
  • Breast Neoplasms–Mortality
  • Carcinoma, Intraductal, Noninfiltrating–Pathology
  • Combined Modality Therapy–Therapy
  • Female–Mortality
  • Humans–Pathology
  • Mastectomy, Segmental–Therapy
  • Neoplasm Recurrence, Local–Therapy
  • Neoplasm Staging–Therapy
  • Postoperative Care–Therapy
  • Radiotherapy, Adjuvant–Therapy
  • Survival Rate–Therapy
  • Treatment Outcome–Therapy
  • Breast Ductal Carcinoma in Situ
  • Breast-Conserving Surgery
  • Early Breast Cancer
  • Older
  • Radiotherapy
ispartof: Oncotarget, April 25, 2017, Vol.8(17), pp.28215-28225
description: BACKGROUNDThere are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTSRadiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS. MATERIALS AND METHODSPubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients. CONCLUSIONSOur study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.15998
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleEffect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis.
creatorHuang, Xuan-Zhang ; Chen, You ; Chen, Wen-Jun ; Zhang, Xi ; Wu, Cong-Cong ; Zhang, Chao-Ying ; Sun, Shuang-Shuang ; Wu, Jian
contributorHuang, Xuan-Zhang (correspondence author) ; Huang, Xuan-Zhang (record owner)
ispartofOncotarget, April 25, 2017, Vol.8(17), pp.28215-28225
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.15998
subjectBreast Neoplasms–Mortality ; Carcinoma, Intraductal, Noninfiltrating–Pathology ; Combined Modality Therapy–Therapy ; Female–Mortality ; Humans–Pathology ; Mastectomy, Segmental–Therapy ; Neoplasm Recurrence, Local–Therapy ; Neoplasm Staging–Therapy ; Postoperative Care–Therapy ; Radiotherapy, Adjuvant–Therapy ; Survival Rate–Therapy ; Treatment Outcome–Therapy ; Breast Ductal Carcinoma in Situ ; Breast-Conserving Surgery ; Early Breast Cancer ; Older ; Radiotherapy
descriptionBACKGROUNDThere are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTSRadiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS. MATERIALS AND METHODSPubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients. CONCLUSIONSOur study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.
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titleEffect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis.
descriptionBACKGROUNDThere are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTSRadiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS. MATERIALS AND METHODSPubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients. CONCLUSIONSOur study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.
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titleEffect of radiotherapy after breast-conserving surgery in older patients with early breast cancer and breast ductal carcinoma in situ: a meta-analysis.
authorHuang, Xuan-Zhang ; Chen, You ; Chen, Wen-Jun ; Zhang, Xi ; Wu, Cong-Cong ; Zhang, Chao-Ying ; Sun, Shuang-Shuang ; Wu, Jian
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abstractBACKGROUNDThere are no consistent agreements on whether radiotherapy after breast-conserving surgery (BCS) could provide local control and survival benefit for older patients with early breast cancer or breast ductal carcinoma in situ (DCIS). The present study aimed to evaluate the efficacy of radiotherapy after BCS in older patients with early breast cancer or DCIS. RESULTSRadiotherapy could reduce the risk of local relapse in older patients with early breast cancer. The 5-year AR of local relapse was 2.2% and 6.2% for radiotherapy and non-radiotherapy group, respectively, with low 5-year ARD of 4.0% and high NNT of 25. The 10-year AR of local relapse was 5.3% and 10.5% for radiotherapy and non-radiotherapy group, respectively, with the 10-year ARD of 5.2% and NNT of 20. However, radiotherapy could not improve survival benefits, including overall survival, cancer-specific survival, breast-cancer-specific survival, and distant relapse. Moreover, radiotherapy could reduce the risk of ipsilateral breast events in older patients with DCIS. MATERIALS AND METHODSPubMed and Embase database were searched for relevant studies. Hazard ratios (HRs), risk ratios (RRs), absolute risk (AR), absolute risk difference (ARD), and number needed to treat (NNT) were used as effect measures to evaluate the efficacy of radiotherapy in older patients. CONCLUSIONSOur study indicates that radiotherapy could slightly reduce the risk of local relapse in older patients with favorable early breast cancer. However, radiotherapy cannot translate into significant survival benefits.
doi10.18632/oncotarget.15998
urlhttp://search.proquest.com/docview/1889384603/
date2017-04-25