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Acyclicl-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA

We report the hybridization properties of a novel artificial nucleic acid: acyclicl-threoninol nucleic acid (l-aTNA). l-aTNA formed a more stable duplex with DNA and RNA than either d-aTNA or serinol nucleic acid (SNA) as the rigidity of the l-form was more optimal for interaction with natural nucle... Full description

Journal Title: Chemical Communications: Chem Comm March 2015, Vol.51(30), pp.6500-6503
Main Author: Murayama, Keiji
Other Authors: Kashida, Hiromu , Asanuma, Hiroyuki
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c4cc09244a
Link: http://search.proquest.com/docview/1893892130/?pq-origsite=primo
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title: Acyclicl-threoninol nucleic acid (l-aTNA) with suitable structural rigidity cross-pairs with DNA and RNA
format: Article
creator:
  • Murayama, Keiji
  • Kashida, Hiromu
  • Asanuma, Hiroyuki
subjects:
  • Rigidity
  • Ribonucleic Acids
  • Deoxyribonucleic Acid
  • Optimization
  • Nucleic Acids
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, March 2015, Vol.51(30), pp.6500-6503
description: We report the hybridization properties of a novel artificial nucleic acid: acyclicl-threoninol nucleic acid (l-aTNA). l-aTNA formed a more stable duplex with DNA and RNA than either d-aTNA or serinol nucleic acid (SNA) as the rigidity of the l-form was more optimal for interaction with natural nucleic acids.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c4cc09244a
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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descriptionWe report the hybridization properties of a novel artificial nucleic acid: acyclicl-threoninol nucleic acid (l-aTNA). l-aTNA formed a more stable duplex with DNA and RNA than either d-aTNA or serinol nucleic acid (SNA) as the rigidity of the l-form was more optimal for interaction with natural nucleic acids.
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abstractWe report the hybridization properties of a novel artificial nucleic acid: acyclicl-threoninol nucleic acid (l-aTNA). l-aTNA formed a more stable duplex with DNA and RNA than either d-aTNA or serinol nucleic acid (SNA) as the rigidity of the l-form was more optimal for interaction with natural nucleic acids.
doi10.1039/c4cc09244a
urlhttp://search.proquest.com/docview/1893892130/
date2015-03-01