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Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells

Synthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA w... Full description

Journal Title: Chemical Communications: Chem Comm April 2015, Vol.51(37), pp.7887-7890
Main Author: Maruyama, Hideto
Other Authors: Furukawa, Kazuhiro , Kamiya, Hiroyuki , Minakawa, Noriaki , Matsuda, Akira
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c4cc08862j
Link: http://search.proquest.com/docview/1893892856/?pq-origsite=primo
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recordid: proquest1893892856
title: Transcription of 4'-thioDNA templates to natural RNA in vitro and in mammalian cells
format: Article
creator:
  • Maruyama, Hideto
  • Furukawa, Kazuhiro
  • Kamiya, Hiroyuki
  • Minakawa, Noriaki
  • Matsuda, Akira
subjects:
  • Genetics
  • Mammals
  • Compatibility
  • Ribonucleic Acids
  • Deoxyribonucleic Acid
  • Biological Materials
  • Nucleic Acids
  • Miscellaneous Sciences (So)
  • Chemical and Electrochemical Properties (MD)
  • Chemical and Electrochemical Properties (Ep)
  • Chemical and Electrochemical Properties (Ed)
  • Chemical and Electrochemical Properties (EC)
ispartof: Chemical Communications: Chem Comm, April 2015, Vol.51(37), pp.7887-7890
description: Synthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2'-deoxy-4'-thionucleosides, so-called 4'-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.
language: eng
source:
identifier: ISSN: 1359-7345 ; E-ISSN: 1364-548X ; DOI: 10.1039/c4cc08862j
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
  • 1364548X
  • 1364-548X
url: Link


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subjectGenetics ; Mammals ; Compatibility ; Ribonucleic Acids ; Deoxyribonucleic Acid ; Biological Materials ; Nucleic Acids ; Miscellaneous Sciences (So) ; Chemical and Electrochemical Properties (MD) ; Chemical and Electrochemical Properties (Ep) ; Chemical and Electrochemical Properties (Ed) ; Chemical and Electrochemical Properties (EC)
descriptionSynthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2'-deoxy-4'-thionucleosides, so-called 4'-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.
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abstractSynthetic chemically modified nucleic acids, which are compatible with DNA/RNA polymerases, have great potential as a genetic material for synthetic biological studies. A comprehensive analysis of the transcription of 4'-thioDNA templates to natural RNA is herein reported. The modifications of DNA with 2'-deoxy-4'-thionucleosides, so-called 4'-thioDNA, were found to act as templates for transcription with RNA polymerases both in vitro and in mammalian cells.
doi10.1039/c4cc08862j
urlhttp://search.proquest.com/docview/1893892856/
date2015-04-01