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Serum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody

Serum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of mid... Full description

Journal Title: Scientific Reports (Nature Publisher Group) Feb 2017, Vol.7, p.43516
Main Author: Jia, Qiang
Other Authors: Meng, Zhaowei , Xu, Ke , He, Xianghui , Tan, Jian , Zhang, Guizhi , Li, Xue , Liu, Na , Hu, Tianpeng , Zhou, Pingping , Wang, Sen , Upadhyaya, Arun , Liu, Xiaoxia , Wang, Huiying , Zhang, Chunmei
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 20452322 ; DOI: 10.1038/srep43516
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title: Serum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody
format: Article
creator:
  • Jia, Qiang
  • Meng, Zhaowei
  • Xu, Ke
  • He, Xianghui
  • Tan, Jian
  • Zhang, Guizhi
  • Li, Xue
  • Liu, Na
  • Hu, Tianpeng
  • Zhou, Pingping
  • Wang, Sen
  • Upadhyaya, Arun
  • Liu, Xiaoxia
  • Wang, Huiying
  • Zhang, Chunmei
subjects:
  • Midkine
  • Biomarkers
  • Thyroid Cancer
  • Antibodies
  • Metastasis
  • Thyroid Cancer
  • Thyroid
  • Metastases
  • Enzyme-Linked Immunosorbent Assay
  • Thyroglobulin
ispartof: Scientific Reports (Nature Publisher Group), Feb 2017, Vol.7, p.43516
description: Serum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first 131 I therapy. MK levels were measured by enzyme-linked immunosorbent assay in 151 recruited DTC patients after exercising strict inclusion and exclusion criteria. There were 28 TgAb positive DTC patients with metastases and 123 DTC patients without metastases. The value of pre-131 I-ablative MK to predict metastasis was assessed by receiver operating characteristic (ROC) curves in these two groups of patients. MK levels in the TgAb positive DTC patients were significantly higher than the DTC patients without metastases. ROC showed good predictability of MK, with an area under the curve of 0.856 (P < 0.001),...
language: eng
source:
identifier: E-ISSN: 20452322 ; DOI: 10.1038/srep43516
fulltext: fulltext_linktorsrc
issn:
  • 20452322
  • 2045-2322
url: Link


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titleSerum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody
creatorJia, Qiang ; Meng, Zhaowei ; Xu, Ke ; He, Xianghui ; Tan, Jian ; Zhang, Guizhi ; Li, Xue ; Liu, Na ; Hu, Tianpeng ; Zhou, Pingping ; Wang, Sen ; Upadhyaya, Arun ; Liu, Xiaoxia ; Wang, Huiying ; Zhang, Chunmei
ispartofScientific Reports (Nature Publisher Group), Feb 2017, Vol.7, p.43516
identifierE-ISSN: 20452322 ; DOI: 10.1038/srep43516
subjectMidkine ; Biomarkers ; Thyroid Cancer ; Antibodies ; Metastasis ; Thyroid Cancer ; Thyroid ; Metastases ; Enzyme-Linked Immunosorbent Assay ; Thyroglobulin
descriptionSerum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first 131 I therapy. MK levels were measured by enzyme-linked immunosorbent assay in 151 recruited DTC patients after exercising strict inclusion and exclusion criteria. There were 28 TgAb positive DTC patients with metastases and 123 DTC patients without metastases. The value of pre-131 I-ablative MK to predict metastasis was assessed by receiver operating characteristic (ROC) curves in these two groups of patients. MK levels in the TgAb positive DTC patients were significantly higher than the DTC patients without metastases. ROC showed good predictability of MK, with an area under the curve of 0.856 (P < 0.001),...
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titleSerum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody
descriptionSerum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first 131 I therapy. MK levels were measured by enzyme-linked immunosorbent assay in 151 recruited DTC patients after exercising strict inclusion and exclusion criteria. There were 28 TgAb positive DTC patients with metastases and 123 DTC patients without metastases. The value of pre-131 I-ablative MK to predict metastasis was assessed by receiver operating characteristic (ROC) curves in these two groups of patients. MK levels in the TgAb positive DTC patients were significantly higher than the DTC patients without metastases. ROC showed good predictability of MK, with an area under the curve of 0.856 (P < 0.001),...
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titleSerum midkine as a surrogate biomarker for metastatic prediction in differentiated thyroid cancer patients with positive thyroglobulin antibody
authorJia, Qiang ; Meng, Zhaowei ; Xu, Ke ; He, Xianghui ; Tan, Jian ; Zhang, Guizhi ; Li, Xue ; Liu, Na ; Hu, Tianpeng ; Zhou, Pingping ; Wang, Sen ; Upadhyaya, Arun ; Liu, Xiaoxia ; Wang, Huiying ; Zhang, Chunmei
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abstractSerum thyroglobulin (Tg) is the main post-operative tumor biomarker for patients with differentiated thyroid cancer (DTC). However, the presence of thyroglobulin antibodies (TgAb) can interfere with Tg level and invalidate the test. In this study, we aimed to investigate the predicative value of midkine (MK) as a cancer biomarker for DTC patients with positive TgAb before the first 131 I therapy. MK levels were measured by enzyme-linked immunosorbent assay in 151 recruited DTC patients after exercising strict inclusion and exclusion criteria. There were 28 TgAb positive DTC patients with metastases and 123 DTC patients without metastases. The value of pre-131 I-ablative MK to predict metastasis was assessed by receiver operating characteristic (ROC) curves in these two groups of patients. MK levels in the TgAb positive DTC patients were significantly higher than the DTC patients without metastases. ROC showed good predictability of MK, with an area under the curve of 0.856 (P < 0.001),...
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