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Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate

Membrane contact sites promote lipid exchangeMost membrane lipids are manufactured in the endoplasmic reticulum (ER). Different organelles and the plasma membrane (PM) have distinct phospholipid compositions. Chung et al., working in mammalian cells, and Moser von Filseck et al., working in yeast, b... Full description

Journal Title: Science July 24, 2015, Vol.349(6246), pp.432-436
Main Author: Moser Von Filseck, Joachim
Other Authors: Copic, Alenka , Delfosse, Vanessa , Vanni, Stefano , Jackson, Catherine , Bourguet, William , Drin, Guillaume
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0036-8075 ; DOI: 10.1126/science.aab1346
Link: http://search.proquest.com/docview/1904239095/?pq-origsite=primo
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title: Phosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
format: Article
creator:
  • Moser Von Filseck, Joachim
  • Copic, Alenka
  • Delfosse, Vanessa
  • Vanni, Stefano
  • Jackson, Catherine
  • Bourguet, William
  • Drin, Guillaume
subjects:
  • Endoplasmic Reticulum
  • Membranes
  • Exchange
  • Transport
  • Lipids
  • Contact
  • Proteins
  • Phospholipids
  • Miscellaneous Sciences (So)
  • (An)
ispartof: Science, July 24, 2015, Vol.349(6246), pp.432-436
description: Membrane contact sites promote lipid exchangeMost membrane lipids are manufactured in the endoplasmic reticulum (ER). Different organelles and the plasma membrane (PM) have distinct phospholipid compositions. Chung et al., working in mammalian cells, and Moser von Filseck et al., working in yeast, both describe how a family of proteins is important in maintaining the balance of lipids within the cell. These special proteins accumulate at and tether contact sites between the ER and the PM and promote the exchange of specific phospholipids, which helps to maintain the PM's distinct identity.Science, this issue pp. 428 and 432 In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter...
language: eng
source:
identifier: ISSN: 0036-8075 ; DOI: 10.1126/science.aab1346
fulltext: no_fulltext
issn:
  • 00368075
  • 0036-8075
url: Link


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titlePhosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
creatorMoser Von Filseck, Joachim ; Copic, Alenka ; Delfosse, Vanessa ; Vanni, Stefano ; Jackson, Catherine ; Bourguet, William ; Drin, Guillaume
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ispartofScience, July 24, 2015, Vol.349(6246), pp.432-436
identifierISSN: 0036-8075 ; DOI: 10.1126/science.aab1346
subjectEndoplasmic Reticulum ; Membranes ; Exchange ; Transport ; Lipids ; Contact ; Proteins ; Phospholipids ; Miscellaneous Sciences (So) ; (An)
descriptionMembrane contact sites promote lipid exchangeMost membrane lipids are manufactured in the endoplasmic reticulum (ER). Different organelles and the plasma membrane (PM) have distinct phospholipid compositions. Chung et al., working in mammalian cells, and Moser von Filseck et al., working in yeast, both describe how a family of proteins is important in maintaining the balance of lipids within the cell. These special proteins accumulate at and tether contact sites between the ER and the PM and promote the exchange of specific phospholipids, which helps to maintain the PM's distinct identity.Science, this issue pp. 428 and 432 In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter...
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titlePhosphatidylserine transport by ORP/Osh proteins is driven by phosphatidylinositol 4-phosphate
descriptionMembrane contact sites promote lipid exchangeMost membrane lipids are manufactured in the endoplasmic reticulum (ER). Different organelles and the plasma membrane (PM) have distinct phospholipid compositions. Chung et al., working in mammalian cells, and Moser von Filseck et al., working in yeast, both describe how a family of proteins is important in maintaining the balance of lipids within the cell. These special proteins accumulate at and tether contact sites between the ER and the PM and promote the exchange of specific phospholipids, which helps to maintain the PM's distinct identity.Science, this issue pp. 428 and 432 In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter...
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abstractMembrane contact sites promote lipid exchangeMost membrane lipids are manufactured in the endoplasmic reticulum (ER). Different organelles and the plasma membrane (PM) have distinct phospholipid compositions. Chung et al., working in mammalian cells, and Moser von Filseck et al., working in yeast, both describe how a family of proteins is important in maintaining the balance of lipids within the cell. These special proteins accumulate at and tether contact sites between the ER and the PM and promote the exchange of specific phospholipids, which helps to maintain the PM's distinct identity.Science, this issue pp. 428 and 432 In eukaryotic cells, phosphatidylserine (PS) is synthesized in the endoplasmic reticulum (ER) but is highly enriched in the plasma membrane (PM), where it contributes negative charge and to specific recruitment of signaling proteins. This distribution relies on transport mechanisms whose nature remains elusive. Here, we found that the PS transporter...
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