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Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.

IL-28B is a member of the newly discovered type III IFN family and exhibits unique antiviral properties compared with other family members. NK cells play a critical role in defending against viruses; however, little is known about the role of IL-28B in NK cell function. In a mouse model of influenza... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), August 1, 2017, Vol.199(3), pp.1012-1020
Main Author: Wang, Yanshi
Other Authors: Li, Tingting , Chen, Yongyan , Wei, Haiming , Sun, Rui , Tian, Zhigang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1601430
Link: http://search.proquest.com/docview/1912611125/?pq-origsite=primo
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title: Involvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.
format: Article
creator:
  • Wang, Yanshi
  • Li, Tingting
  • Chen, Yongyan
  • Wei, Haiming
  • Sun, Rui
  • Tian, Zhigang
subjects:
  • Animals–Genetics
  • Cd11b Antigen–Immunology
  • Cell Differentiation–Genetics
  • Cell Proliferation–Immunology
  • Coculture Techniques–Metabolism
  • Cytokines–Pharmacology
  • Disease Models, Animal–Immunology
  • Humans–Immunology
  • Influenza A Virus–Virology
  • Influenza, Human–Drug Effects
  • Killer Cells, Natural–Immunology
  • Liver–Physiology
  • Lung–Immunology
  • Macrophages, Alveolar–Immunology
  • Mice–Virology
  • Orthomyxoviridae Infections–Immunology
  • Receptors, Immunologic–Physiology
  • Spleen–Immunology
  • Tumor Necrosis Factor Receptor Superfamily, Member 7–Virology
  • Tumor Necrosis Factor Receptor Superfamily, Member 7
ispartof: Journal of immunology (Baltimore, Md. : 1950), August 1, 2017, Vol.199(3), pp.1012-1020
description: IL-28B is a member of the newly discovered type III IFN family and exhibits unique antiviral properties compared with other family members. NK cells play a critical role in defending against viruses; however, little is known about the role of IL-28B in NK cell function. In a mouse model of influenza A virus (mouse adapted influenza A/PR/8/34 strain) infection, long-term overexpression of IL-28B induced by hepatocyte-specific gene delivery exerted a strong antiviral effect in the presence of NK cells. In IL-28B–overexpressing wild-type mice, the percentages and absolute numbers of NK cells in the spleen, liver, and lung were markedly increased, with higher proliferation and accelerated NK cell maturation based on phenotypes staining with CD11b and CD27 or CD11b and KLRG1. Furthermore, the effect of IL-28B on NK cells was macrophage dependent, as confirmed in an in vitro coculture assay and in in vivo macrophage- or alveolar macrophage–depletion experiments. Transwell studies demonstrated...
language: eng
source:
identifier: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1601430
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleInvolvement of NK Cells in IL-28B-Mediated Immunity against Influenza Virus Infection.
creatorWang, Yanshi ; Li, Tingting ; Chen, Yongyan ; Wei, Haiming ; Sun, Rui ; Tian, Zhigang
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identifierE-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1601430
subjectAnimals–Genetics ; Cd11b Antigen–Immunology ; Cell Differentiation–Genetics ; Cell Proliferation–Immunology ; Coculture Techniques–Metabolism ; Cytokines–Pharmacology ; Disease Models, Animal–Immunology ; Humans–Immunology ; Influenza A Virus–Virology ; Influenza, Human–Drug Effects ; Killer Cells, Natural–Immunology ; Liver–Physiology ; Lung–Immunology ; Macrophages, Alveolar–Immunology ; Mice–Virology ; Orthomyxoviridae Infections–Immunology ; Receptors, Immunologic–Physiology ; Spleen–Immunology ; Tumor Necrosis Factor Receptor Superfamily, Member 7–Virology ; Tumor Necrosis Factor Receptor Superfamily, Member 7
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descriptionIL-28B is a member of the newly discovered type III IFN family and exhibits unique antiviral properties compared with other family members. NK cells play a critical role in defending against viruses; however, little is known about the role of IL-28B in NK cell function. In a mouse model of influenza A virus (mouse adapted influenza A/PR/8/34 strain) infection, long-term overexpression of IL-28B induced by hepatocyte-specific gene delivery exerted a strong antiviral effect in the presence of NK cells. In IL-28B–overexpressing wild-type mice, the percentages and absolute numbers of NK cells in the spleen, liver, and lung were markedly increased, with higher proliferation and accelerated NK cell maturation based on phenotypes staining with CD11b and CD27 or CD11b and KLRG1. Furthermore, the effect of IL-28B on NK cells was macrophage dependent, as confirmed in an in vitro coculture assay and in in vivo macrophage- or alveolar macrophage–depletion experiments. Transwell studies demonstrated...
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