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Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken

Background Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and... Full description

Journal Title: Microbiome 2017, Vol.5
Main Author: Gao, Pengfei
Other Authors: Chen, Ma , Sun, Zheng , Wang, Lifeng , Huang, Shi , Su, Xiaoquan , Xu, Jian , Zhang, Heping
Format: Electronic Article Electronic Article
Language: English
Subjects:
Age
ID: E-ISSN: 20492618 ; DOI: 10.1186/s40168-017-0315-1
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title: Feed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
format: Article
creator:
  • Gao, Pengfei
  • Chen, Ma
  • Sun, Zheng
  • Wang, Lifeng
  • Huang, Shi
  • Su, Xiaoquan
  • Xu, Jian
  • Zhang, Heping
subjects:
  • China
  • Physiology
  • Intestine
  • Alternatives
  • Intestinal Microflora
  • Probiotics
  • Farming
  • Food Contamination & Poisoning
  • Feces
  • Feeding
  • Bioinformatics
  • Probiotics
  • Slaughter
  • Animals
  • Antibiotics
  • Immunology
  • Age
  • Diet
  • Data Analysis
  • Drinking Water
  • Antibiotic Resistance
  • Performance Evaluation
  • Poultry
  • Antibiotics
  • Poultry Farming
  • Probiotics
  • Intestinal Microbiota
  • Broiler
  • Antibiotic Overuse
  • Antibiotic Resistance
ispartof: Microbiome, 2017, Vol.5
description: Background Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, “intestinal microbiota maturation index” was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions Our results reveal a tremendous potential of probiotics as antibiotics’ substitute in poultry farming.
language: eng
source:
identifier: E-ISSN: 20492618 ; DOI: 10.1186/s40168-017-0315-1
fulltext: fulltext_linktorsrc
issn:
  • 20492618
  • 2049-2618
url: Link


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titleFeed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
creatorGao, Pengfei ; Chen, Ma ; Sun, Zheng ; Wang, Lifeng ; Huang, Shi ; Su, Xiaoquan ; Xu, Jian ; Zhang, Heping
ispartofMicrobiome, 2017, Vol.5
identifierE-ISSN: 20492618 ; DOI: 10.1186/s40168-017-0315-1
subjectChina ; Physiology ; Intestine ; Alternatives ; Intestinal Microflora ; Probiotics ; Farming ; Food Contamination & Poisoning ; Feces ; Feeding ; Bioinformatics ; Probiotics ; Slaughter ; Animals ; Antibiotics ; Immunology ; Age ; Diet ; Data Analysis ; Drinking Water ; Antibiotic Resistance ; Performance Evaluation ; Poultry ; Antibiotics ; Poultry Farming ; Probiotics ; Intestinal Microbiota ; Broiler ; Antibiotic Overuse ; Antibiotic Resistance
descriptionBackground Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, “intestinal microbiota maturation index” was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions Our results reveal a tremendous potential of probiotics as antibiotics’ substitute in poultry farming.
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titleFeed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
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titleFeed-additive probiotics accelerate yet antibiotics delay intestinal microbiota maturation in broiler chicken
authorGao, Pengfei ; Chen, Ma ; Sun, Zheng ; Wang, Lifeng ; Huang, Shi ; Su, Xiaoquan ; Xu, Jian ; Zhang, Heping
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abstractBackground Reducing antibiotics overuse in animal agriculture is one key in combat against the spread of antibiotic resistance. Probiotics are a potential replacement of antibiotics in animal feed; however, it is not clear whether and how probiotics and antibiotics differ in impact on physiology and microbial ecology of host animals. Results Host phenotype and fecal microbiota of broilers with either antibiotics or probiotics as feed additive were simultaneously sampled at four time points from birth to slaughter and then compared. Probiotic feeding resulted in a lower feed conversion ratio (FCR) and induced the highest level of immunity response, suggesting greater economic benefits in broiler farming. Probiotic use but not antibiotic use recapitulated the characteristics of age-dependent development of gut microbiota in the control group. The maturation of intestinal microbiota was greatly accelerated by probiotic feeding, yet significantly retarded and eventually delayed by antibiotic feeding. LP-8 stimulated the growth of many intestinal Lactobacillus spp. and led to an altered bacterial correlation network where Lactobacillus spp. are negatively correlated with 14 genera and positively linked with none, yet from the start antibiotic feeding featured a less-organized network where such inter-genera interactions were fewer and weaker. Consistently, microbiota-encoded functions as revealed by metagenome sequencing were highly distinct between the two groups. Thus, “intestinal microbiota maturation index” was proposed to quantitatively compare impact of feed additives on animal microecology. Conclusions Our results reveal a tremendous potential of probiotics as antibiotics’ substitute in poultry farming.
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