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Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer.

To compare protein expression levels, gene mutation and survival among Right-Sided Colon Cancer (RSCC), Left-Sided Colon Cancer (LSCC) and rectal cancer patients, 57 cases of RSCC, 87 LSCC and 145 rectal cancer patients were included retrospectively. Our results demonstrated significant differences... Full description

Journal Title: Scientific reports August 11, 2017, Vol.7(1), p.7882
Main Author: Gao, Xian Hua
Other Authors: Yu, Guan Yu , Gong, Hai Feng , Liu, Lian Jie , Xu, Yi , Hao, Li Qiang , Liu, Peng , Liu, Zhi Hong , Bai, Chen Guang , Zhang, Wei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2045-2322 ; DOI: 10.1038/s41598-017-08413-z
Link: http://search.proquest.com/docview/1928515245/?pq-origsite=primo
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title: Differences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer.
format: Article
creator:
  • Gao, Xian Hua
  • Yu, Guan Yu
  • Gong, Hai Feng
  • Liu, Lian Jie
  • Xu, Yi
  • Hao, Li Qiang
  • Liu, Peng
  • Liu, Zhi Hong
  • Bai, Chen Guang
  • Zhang, Wei
subjects:
  • Aged–Metabolism
  • Colon–Pathology
  • Colonic Neoplasms–Genetics
  • Female–Metabolism
  • Humans–Therapy
  • Male–Genetics
  • Middle Aged–Metabolism
  • Multivariate Analysis–Methods
  • Mutation–Genetics
  • Neoplasm Staging–Metabolism
  • Prognosis–Genetics
  • Progression-Free Survival–Metabolism
  • Proteome–Genetics
  • Proteomics–Metabolism
  • Proto-Oncogene Proteins B-Raf–Therapy
  • Proto-Oncogene Proteins P21(Ras)–Therapy
  • Rectal Neoplasms–Therapy
  • Retrospective Studies–Therapy
  • Kras Protein, Human
  • Proteome
  • Braf Protein, Human
  • Proto-Oncogene Proteins B-Raf
  • Proto-Oncogene Proteins P21(Ras)
ispartof: Scientific reports, August 11, 2017, Vol.7(1), p.7882
description: To compare protein expression levels, gene mutation and survival among Right-Sided Colon Cancer (RSCC), Left-Sided Colon Cancer (LSCC) and rectal cancer patients, 57 cases of RSCC, 87 LSCC and 145 rectal cancer patients were included retrospectively. Our results demonstrated significant differences existed among RSCC, LSCC and rectal cancer regarding tumor diameter, differentiation, invasion depth and TNM stage. No significant difference was identified in expression levels of MLH1, MSH2, MSH6, PMS2, β-Tubulin III, P53, Ki67 and TOPIIα, and gene mutation of KRAS and BRAF among three groups. Progression Free Survival (PFS) of RSCC was significantly lower than that of LRCC and rectal cancer. In univariate analyses, RSCC, preoperative chemoradiotherapy, poor differentiation, advanced TNM stage, elevated serum CEA and CA19-9 level, tumor deposit, perineural and vascular invasion were found to be predictive factors of shorter PFS. In multivariate analyses, only differentiation and TNM stages were found to be independent predictors of PFS. In conclusion, compared with LSCC and rectal cancer, RSCC has larger tumor size, poor differentiation, advanced TNM stage and shorter survival. The shorter survival in RSCC might be attributed to the advanced tumor stage caused by its inherent position feature of proximal colon rather than genetic difference.
language: eng
source:
identifier: E-ISSN: 2045-2322 ; DOI: 10.1038/s41598-017-08413-z
fulltext: fulltext
issn:
  • 20452322
  • 2045-2322
url: Link


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titleDifferences of protein expression profiles, KRAS and BRAF mutation, and prognosis in right-sided colon, left-sided colon and rectal cancer.
creatorGao, Xian Hua ; Yu, Guan Yu ; Gong, Hai Feng ; Liu, Lian Jie ; Xu, Yi ; Hao, Li Qiang ; Liu, Peng ; Liu, Zhi Hong ; Bai, Chen Guang ; Zhang, Wei
contributorGao, Xian Hua (correspondence author) ; Gao, Xian Hua (record owner)
ispartofScientific reports, August 11, 2017, Vol.7(1), p.7882
identifierE-ISSN: 2045-2322 ; DOI: 10.1038/s41598-017-08413-z
subjectAged–Metabolism ; Colon–Pathology ; Colonic Neoplasms–Genetics ; Female–Metabolism ; Humans–Therapy ; Male–Genetics ; Middle Aged–Metabolism ; Multivariate Analysis–Methods ; Mutation–Genetics ; Neoplasm Staging–Metabolism ; Prognosis–Genetics ; Progression-Free Survival–Metabolism ; Proteome–Genetics ; Proteomics–Metabolism ; Proto-Oncogene Proteins B-Raf–Therapy ; Proto-Oncogene Proteins P21(Ras)–Therapy ; Rectal Neoplasms–Therapy ; Retrospective Studies–Therapy ; Kras Protein, Human ; Proteome ; Braf Protein, Human ; Proto-Oncogene Proteins B-Raf ; Proto-Oncogene Proteins P21(Ras)
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descriptionTo compare protein expression levels, gene mutation and survival among Right-Sided Colon Cancer (RSCC), Left-Sided Colon Cancer (LSCC) and rectal cancer patients, 57 cases of RSCC, 87 LSCC and 145 rectal cancer patients were included retrospectively. Our results demonstrated significant differences existed among RSCC, LSCC and rectal cancer regarding tumor diameter, differentiation, invasion depth and TNM stage. No significant difference was identified in expression levels of MLH1, MSH2, MSH6, PMS2, β-Tubulin III, P53, Ki67 and TOPIIα, and gene mutation of KRAS and BRAF among three groups. Progression Free Survival (PFS) of RSCC was significantly lower than that of LRCC and rectal cancer. In univariate analyses, RSCC, preoperative chemoradiotherapy, poor differentiation, advanced TNM stage, elevated serum CEA and CA19-9 level, tumor deposit, perineural and vascular invasion were found to be predictive factors of shorter PFS. In multivariate analyses, only differentiation and TNM stages were found to be independent predictors of PFS. In conclusion, compared with LSCC and rectal cancer, RSCC has larger tumor size, poor differentiation, advanced TNM stage and shorter survival. The shorter survival in RSCC might be attributed to the advanced tumor stage caused by its inherent position feature of proximal colon rather than genetic difference.
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authorGao, Xian Hua ; Yu, Guan Yu ; Gong, Hai Feng ; Liu, Lian Jie ; Xu, Yi ; Hao, Li Qiang ; Liu, Peng ; Liu, Zhi Hong ; Bai, Chen Guang ; Zhang, Wei
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