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Bioinformatics analysis of gene expression profiles of dermatomyositis

Dermatomyositis (DM) is a type of autoimmune inflammatory myopathy, which primarily affects the skin and muscle. The underlying mechanisms of DM remain poorly understood. The present study aimed to explore gene expression profile alterations, investigate the underlying mechanisms, and identify novel... Full description

Journal Title: Molecular Medicine Reports 2016, Vol.14(4), pp.3785-3790
Main Author: Chen, Liang-Yuan
Other Authors: Cui, Zhao-Lei , Hua, Fan-Cui , Yang, Weng-Jing , Bai, Ye , Lan, Feng-Hua
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 17912997 ; E-ISSN: 17913004 ; DOI: 10.3892/mmr.2016.5703
Link: http://search.proquest.com/docview/1932478142/?pq-origsite=primo
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title: Bioinformatics analysis of gene expression profiles of dermatomyositis
format: Article
creator:
  • Chen, Liang-Yuan
  • Cui, Zhao-Lei
  • Hua, Fan-Cui
  • Yang, Weng-Jing
  • Bai, Ye
  • Lan, Feng-Hua
subjects:
  • Infections
  • Software
  • Toll-Like Receptors
  • Bioinformatics
  • Ontology
  • Disease
  • Genomes
  • Guanosinetriphosphatase
  • Bioinformatics
  • Cytokines
  • Genomes
  • Thyroid Gland
  • Immune System
  • Skin
  • Interferon
  • DNA Helicase
  • Proteins
  • Protein Interaction
  • Inflammation
  • Myopathy
ispartof: Molecular Medicine Reports, 2016, Vol.14(4), pp.3785-3790
description: Dermatomyositis (DM) is a type of autoimmune inflammatory myopathy, which primarily affects the skin and muscle. The underlying mechanisms of DM remain poorly understood. The present study aimed to explore gene expression profile alterations, investigate the underlying mechanisms, and identify novel targets for DM. The GSE48280 dataset, which includes data from five DM and five normal muscle tissue samples, was obtained from the Gene Expression Omnibus. Firstly, differentially expressed genes (DEGs) were screened by limma package in R. Subsequently, functional and pathway enrichment analyses were performed using ClueGO from Cytoscape. Finally, protein-protein interaction (PPI) networks were constructed using STRING and Cytoscape, in order to identify hub genes. As a result, 180 upregulated and 21 downregulated genes were identified in the DM samples. The Gene Ontology enrichment analysis revealed that the type I interferon (IFN) signaling pathway was the most significantly enriched term...
language: eng
source:
identifier: ISSN: 17912997 ; E-ISSN: 17913004 ; DOI: 10.3892/mmr.2016.5703
fulltext: fulltext
issn:
  • 17912997
  • 1791-2997
  • 17913004
  • 1791-3004
url: Link


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titleBioinformatics analysis of gene expression profiles of dermatomyositis
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subjectInfections ; Software ; Toll-Like Receptors ; Bioinformatics ; Ontology ; Disease ; Genomes ; Guanosinetriphosphatase ; Bioinformatics ; Cytokines ; Genomes ; Thyroid Gland ; Immune System ; Skin ; Interferon ; DNA Helicase ; Proteins ; Protein Interaction ; Inflammation ; Myopathy
descriptionDermatomyositis (DM) is a type of autoimmune inflammatory myopathy, which primarily affects the skin and muscle. The underlying mechanisms of DM remain poorly understood. The present study aimed to explore gene expression profile alterations, investigate the underlying mechanisms, and identify novel targets for DM. The GSE48280 dataset, which includes data from five DM and five normal muscle tissue samples, was obtained from the Gene Expression Omnibus. Firstly, differentially expressed genes (DEGs) were screened by limma package in R. Subsequently, functional and pathway enrichment analyses were performed using ClueGO from Cytoscape. Finally, protein-protein interaction (PPI) networks were constructed using STRING and Cytoscape, in order to identify hub genes. As a result, 180 upregulated and 21 downregulated genes were identified in the DM samples. The Gene Ontology enrichment analysis revealed that the type I interferon (IFN) signaling pathway was the most significantly enriched term...
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titleBioinformatics analysis of gene expression profiles of dermatomyositis
descriptionDermatomyositis (DM) is a type of autoimmune inflammatory myopathy, which primarily affects the skin and muscle. The underlying mechanisms of DM remain poorly understood. The present study aimed to explore gene expression profile alterations, investigate the underlying mechanisms, and identify novel targets for DM. The GSE48280 dataset, which includes data from five DM and five normal muscle tissue samples, was obtained from the Gene Expression Omnibus. Firstly, differentially expressed genes (DEGs) were screened by limma package in R. Subsequently, functional and pathway enrichment analyses were performed using ClueGO from Cytoscape. Finally, protein-protein interaction (PPI) networks were constructed using STRING and Cytoscape, in order to identify hub genes. As a result, 180 upregulated and 21 downregulated genes were identified in the DM samples. The Gene Ontology enrichment analysis revealed that the type I interferon (IFN) signaling pathway was the most significantly enriched term...
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titleBioinformatics analysis of gene expression profiles of dermatomyositis
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abstractDermatomyositis (DM) is a type of autoimmune inflammatory myopathy, which primarily affects the skin and muscle. The underlying mechanisms of DM remain poorly understood. The present study aimed to explore gene expression profile alterations, investigate the underlying mechanisms, and identify novel targets for DM. The GSE48280 dataset, which includes data from five DM and five normal muscle tissue samples, was obtained from the Gene Expression Omnibus. Firstly, differentially expressed genes (DEGs) were screened by limma package in R. Subsequently, functional and pathway enrichment analyses were performed using ClueGO from Cytoscape. Finally, protein-protein interaction (PPI) networks were constructed using STRING and Cytoscape, in order to identify hub genes. As a result, 180 upregulated and 21 downregulated genes were identified in the DM samples. The Gene Ontology enrichment analysis revealed that the type I interferon (IFN) signaling pathway was the most significantly enriched term...
copAthens
pubSpandidos Publications UK Ltd.
doi10.3892/mmr.2016.5703
urlhttp://search.proquest.com/docview/1932478142/
pages3785-37890
date2016-01-01