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GE11 peptide-conjugated nanoliposomes to enhance the combinational therapeutic efficacy of docetaxel and siRNA in laryngeal cancers.

In this study, dual therapeutic-loaded GE11 peptide-conjugated liposomes were developed and applied to enhance therapeutic efficacies of standard-of-care regimens for the treatment of laryngeal cancer. The therapeutic strategy used here was a combination treatment with the chemotherapeutic docetaxel... Full description

Journal Title: International journal of nanomedicine 2017, Vol.12, pp.6461-6470
Main Author: Xu, Wei-Wei
Other Authors: Liu, Da-Yu , Cao, Ying-Chun , Wang, Xiang-Yun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S129946
Link: http://search.proquest.com/docview/1940191619/?pq-origsite=primo
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recordid: proquest1940191619
title: GE11 peptide-conjugated nanoliposomes to enhance the combinational therapeutic efficacy of docetaxel and siRNA in laryngeal cancers.
format: Article
creator:
  • Xu, Wei-Wei
  • Liu, Da-Yu
  • Cao, Ying-Chun
  • Wang, Xiang-Yun
subjects:
  • ATP Binding Cassette Transporter, Subfamily G, Member 2–Genetics
  • Animals–Administration & Dosage
  • Antineoplastic Agents–Chemistry
  • Cell Line, Tumor–Methods
  • Docetaxel–Drug Therapy
  • Drug Delivery Systems–Chemistry
  • Hep G2 Cells–Administration & Dosage
  • Humans–Chemistry
  • Laryngeal Neoplasms–Administration & Dosage
  • Lipid Bilayers–Chemistry
  • Liposomes–Genetics
  • Mice, Nude–Chemistry
  • Nanoparticles–Administration & Dosage
  • Neoplasm Proteins–Administration & Dosage
  • Peptides–Methods
  • RNA, Small Interfering–Methods
  • Static Electricity–Methods
  • Taxoids–Methods
  • Xenograft Model Antitumor Assays–Methods
  • Abcg2 Protein, Human
  • ATP Binding Cassette Transporter, Subfamily G, Member 2
  • Antineoplastic Agents
  • Ge11 Peptide
  • Lipid Bilayers
  • Liposomes
  • Neoplasm Proteins
  • Peptides
  • RNA, Small Interfering
  • Taxoids
  • Docetaxel
  • Abcg2–Sirna
  • Ge11 Peptide-Targeted Liposomes
  • Anti-Tumor Efficacy
  • Docetaxel
  • Laryngeal Cancer
  • Liposomal Chemotherapy Carriers
ispartof: International journal of nanomedicine, 2017, Vol.12, pp.6461-6470
description: In this study, dual therapeutic-loaded GE11 peptide-conjugated liposomes were developed and applied to enhance therapeutic efficacies of standard-of-care regimens for the treatment of laryngeal cancer. The therapeutic strategy used here was a combination treatment with the chemotherapeutic docetaxel (DTX) and siRNA against the ABCG2 gene that regulates multidrug resistance in many tumor types. Liposome-encapsulated DTX/ABCG2-siRNA molecules were targeted to recognize tumor cells of squamous morphology by conjugation to the EGFR-targeting ligand, GE11. Targeted, drug-infused liposomes were nanosized and exhibited controlled release of DTX. Presence of GE11 peptides on liposomal surfaces enhanced the quantities of liposomal constructs taken up by Hep-2 laryngeal cancer cells. GE11 peptide-conjugated liposomes also enhanced cytotoxic effects against Hep-2 laryngeal cancer cells when compared to treatment with free DTX, thereby reducing I[C.sub.50] values. Additionally, GE11 peptide-conjugated liposomes had significantly increased anti-tumor and apoptotic effects. Treatments with the GDSL nanoparticle formulation inhibited tumor growth in Hep-2 xenograft-bearing nude mouse models when compared to treatments with non-targeted NP constructs. Treatment of the mouse models with GE11 peptide-conjugated liposomes mitigated toxicities observed after treatment with free DTX. Taken together, liposomal encapsulation of DTX and ABCG2-siRNA improved the anti-tumor effects of treatment with free DTX in Hep-2 cell lines, and conjugation of GE11 peptides to liposomal constructs enhanced anti-tumor efficacies and specificities in laryngeal cancer cells. Keywords: laryngeal cancer, docetaxel, ABCG2-siRNA, anti-tumor efficacy, liposomal chemotherapy carriers, GE11 peptide-targeted liposomes
language: eng
source:
identifier: E-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S129946
fulltext: fulltext
issn:
  • 11782013
  • 1178-2013
url: Link


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titleGE11 peptide-conjugated nanoliposomes to enhance the combinational therapeutic efficacy of docetaxel and siRNA in laryngeal cancers.
creatorXu, Wei-Wei ; Liu, Da-Yu ; Cao, Ying-Chun ; Wang, Xiang-Yun
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ispartofInternational journal of nanomedicine, 2017, Vol.12, pp.6461-6470
identifierE-ISSN: 1178-2013 ; DOI: 10.2147/IJN.S129946
subjectATP Binding Cassette Transporter, Subfamily G, Member 2–Genetics ; Animals–Administration & Dosage ; Antineoplastic Agents–Chemistry ; Cell Line, Tumor–Methods ; Docetaxel–Drug Therapy ; Drug Delivery Systems–Chemistry ; Hep G2 Cells–Administration & Dosage ; Humans–Chemistry ; Laryngeal Neoplasms–Administration & Dosage ; Lipid Bilayers–Chemistry ; Liposomes–Genetics ; Mice, Nude–Chemistry ; Nanoparticles–Administration & Dosage ; Neoplasm Proteins–Administration & Dosage ; Peptides–Methods ; RNA, Small Interfering–Methods ; Static Electricity–Methods ; Taxoids–Methods ; Xenograft Model Antitumor Assays–Methods ; Abcg2 Protein, Human ; ATP Binding Cassette Transporter, Subfamily G, Member 2 ; Antineoplastic Agents ; Ge11 Peptide ; Lipid Bilayers ; Liposomes ; Neoplasm Proteins ; Peptides ; RNA, Small Interfering ; Taxoids ; Docetaxel ; Abcg2–Sirna ; Ge11 Peptide-Targeted Liposomes ; Anti-Tumor Efficacy ; Docetaxel ; Laryngeal Cancer ; Liposomal Chemotherapy Carriers
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descriptionIn this study, dual therapeutic-loaded GE11 peptide-conjugated liposomes were developed and applied to enhance therapeutic efficacies of standard-of-care regimens for the treatment of laryngeal cancer. The therapeutic strategy used here was a combination treatment with the chemotherapeutic docetaxel (DTX) and siRNA against the ABCG2 gene that regulates multidrug resistance in many tumor types. Liposome-encapsulated DTX/ABCG2-siRNA molecules were targeted to recognize tumor cells of squamous morphology by conjugation to the EGFR-targeting ligand, GE11. Targeted, drug-infused liposomes were nanosized and exhibited controlled release of DTX. Presence of GE11 peptides on liposomal surfaces enhanced the quantities of liposomal constructs taken up by Hep-2 laryngeal cancer cells. GE11 peptide-conjugated liposomes also enhanced cytotoxic effects against Hep-2 laryngeal cancer cells when compared to treatment with free DTX, thereby reducing I[C.sub.50] values. Additionally, GE11 peptide-conjugated liposomes had significantly increased anti-tumor and apoptotic effects. Treatments with the GDSL nanoparticle formulation inhibited tumor growth in Hep-2 xenograft-bearing nude mouse models when compared to treatments with non-targeted NP constructs. Treatment of the mouse models with GE11 peptide-conjugated liposomes mitigated toxicities observed after treatment with free DTX. Taken together, liposomal encapsulation of DTX and ABCG2-siRNA improved the anti-tumor effects of treatment with free DTX in Hep-2 cell lines, and conjugation of GE11 peptides to liposomal constructs enhanced anti-tumor efficacies and specificities in laryngeal cancer cells. Keywords: laryngeal cancer, docetaxel, ABCG2-siRNA, anti-tumor efficacy, liposomal chemotherapy carriers, GE11 peptide-targeted liposomes
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