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Brain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients

Background Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors for severe BG-EPVS in patients with acute lacunar stroke. M... Full description

Journal Title: PLoS One Feb 2016, Vol.11(2), p.e0149593
Main Author: Zhang, Xiaoyu
Other Authors: Ding, Lingling , Yang, Lei , Qin, Wei , Yuan, Junliang , Li, Shujuan , Hu, Wenli
Format: Electronic Article Electronic Article
Language: English
Subjects:
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ID: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0149593
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title: Brain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients
format: Article
creator:
  • Zhang, Xiaoyu
  • Ding, Lingling
  • Yang, Lei
  • Qin, Wei
  • Yuan, Junliang
  • Li, Shujuan
  • Hu, Wenli
subjects:
  • Beijing China
  • Cognitive Ability
  • Risk Management
  • Magnetic Resonance Imaging
  • Etiology
  • Brain
  • Nuclear Magnetic Resonance–NMR
  • Patients
  • Hospitals
  • Brain
  • Basal Ganglia
  • Older People
  • Medical Imaging
  • Ganglia
  • Risk Analysis
  • Atrophy
  • Stroke
  • Age
  • Dementia Disorders
ispartof: PLoS One, Feb 2016, Vol.11(2), p.e0149593
description: Background Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors for severe BG-EPVS in patients with acute lacunar stroke. Methods We prospectively identified patients with lacunar stroke (diameter on DWI ≤ 20mm) from Jan 2011 to May 2015. Patients with severe BG-EPVS were identified on T2 weighted MRI. Age (± 1 year) and sex matched controls were also recruited in the same population (two controls for one case). Vascular risk factors, clinical data, EPVS in centrum semiovale (rated 0 to 4), white matter hyperintensities (WMH) (by Fazekas scale), brain atrophy (rated 0 to 6) were compared between two groups. Logistic regression was performed to determine independent risk factors for severe BG-EPVS. Results During study period, 89 patients with severe BG-EPVS and 178 matched controls were included. Vascular risk factors...
language: eng
source:
identifier: E-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0149593
fulltext: fulltext_linktorsrc
issn:
  • 19326203
  • 1932-6203
url: Link


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titleBrain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients
creatorZhang, Xiaoyu ; Ding, Lingling ; Yang, Lei ; Qin, Wei ; Yuan, Junliang ; Li, Shujuan ; Hu, Wenli
ispartofPLoS One, Feb 2016, Vol.11(2), p.e0149593
identifierE-ISSN: 19326203 ; DOI: 10.1371/journal.pone.0149593
subjectBeijing China ; Cognitive Ability ; Risk Management ; Magnetic Resonance Imaging ; Etiology ; Brain ; Nuclear Magnetic Resonance–NMR ; Patients ; Hospitals ; Brain ; Basal Ganglia ; Older People ; Medical Imaging ; Ganglia ; Risk Analysis ; Atrophy ; Stroke ; Age ; Dementia Disorders
descriptionBackground Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors for severe BG-EPVS in patients with acute lacunar stroke. Methods We prospectively identified patients with lacunar stroke (diameter on DWI ≤ 20mm) from Jan 2011 to May 2015. Patients with severe BG-EPVS were identified on T2 weighted MRI. Age (± 1 year) and sex matched controls were also recruited in the same population (two controls for one case). Vascular risk factors, clinical data, EPVS in centrum semiovale (rated 0 to 4), white matter hyperintensities (WMH) (by Fazekas scale), brain atrophy (rated 0 to 6) were compared between two groups. Logistic regression was performed to determine independent risk factors for severe BG-EPVS. Results During study period, 89 patients with severe BG-EPVS and 178 matched controls were included. Vascular risk factors...
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titleBrain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients
descriptionBackground Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors for severe BG-EPVS in patients with acute lacunar stroke. Methods We prospectively identified patients with lacunar stroke (diameter on DWI ≤ 20mm) from Jan 2011 to May 2015. Patients with severe BG-EPVS were identified on T2 weighted MRI. Age (± 1 year) and sex matched controls were also recruited in the same population (two controls for one case). Vascular risk factors, clinical data, EPVS in centrum semiovale (rated 0 to 4), white matter hyperintensities (WMH) (by Fazekas scale), brain atrophy (rated 0 to 6) were compared between two groups. Logistic regression was performed to determine independent risk factors for severe BG-EPVS. Results During study period, 89 patients with severe BG-EPVS and 178 matched controls were included. Vascular risk factors...
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titleBrain Atrophy Correlates with Severe Enlarged Perivascular Spaces in Basal Ganglia among Lacunar Stroke Patients
authorZhang, Xiaoyu ; Ding, Lingling ; Yang, Lei ; Qin, Wei ; Yuan, Junliang ; Li, Shujuan ; Hu, Wenli
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abstractBackground Enlarged perivascular spaces (EPVS) correlate with cognitive impairment and incident dementia. However, etiologies for severe basal ganglia EPVS (BG-EPVS) are still unclear. Our aim was to investigate the independent risk factors for severe BG-EPVS in patients with acute lacunar stroke. Methods We prospectively identified patients with lacunar stroke (diameter on DWI ≤ 20mm) from Jan 2011 to May 2015. Patients with severe BG-EPVS were identified on T2 weighted MRI. Age (± 1 year) and sex matched controls were also recruited in the same population (two controls for one case). Vascular risk factors, clinical data, EPVS in centrum semiovale (rated 0 to 4), white matter hyperintensities (WMH) (by Fazekas scale), brain atrophy (rated 0 to 6) were compared between two groups. Logistic regression was performed to determine independent risk factors for severe BG-EPVS. Results During study period, 89 patients with severe BG-EPVS and 178 matched controls were included. Vascular risk factors...
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