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Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus.

Mechanical damage can induce fruiting body production in fungi. In this study, the antioxidant kojic acid (KA) was found to enhance injured mycelial regeneration and increase fruiting body production in Hypsizygus marmoreus. KA reduced the level of reactive oxygen species (ROS), which are harmful to... Full description

Journal Title: PloS one 2017, Vol.12(11), p.e0187351
Main Author: Zhang, Jinjing
Other Authors: Chen, Hui , Chen, Mingjie , Wang, Hong , Wang, Qian , Song, Xiaoxia , Hao, Haibo , Feng, Zhiyong
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0187351
Link: http://search.proquest.com/docview/1962430367/?pq-origsite=primo
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recordid: proquest1962430367
title: Kojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus.
format: Article
creator:
  • Zhang, Jinjing
  • Chen, Hui
  • Chen, Mingjie
  • Wang, Hong
  • Wang, Qian
  • Song, Xiaoxia
  • Hao, Haibo
  • Feng, Zhiyong
subjects:
  • Adenosine Triphosphate–Metabolism
  • Antioxidants–Metabolism
  • Basidiomycota–Drug Effects
  • Cluster Analysis–Genetics
  • Fruiting Bodies, Fungal–Physiology
  • Gene Expression Profiling–Drug Effects
  • Gene Expression Regulation, Fungal–Physiology
  • Laccase–Drug Effects
  • Models, Biological–Genetics
  • Molecular Sequence Annotation–Metabolism
  • Mycelium–Drug Effects
  • Pyrones–Physiology
  • Reactive Oxygen Species–Pharmacology
  • Regeneration–Metabolism
  • Sequence Analysis, RNA–Drug Effects
  • Signal Transduction–Drug Effects
  • Transcriptome–Genetics
  • Transcriptome–Genetics
  • Antioxidants
  • Pyrones
  • Reactive Oxygen Species
  • Kojic Acid
  • Adenosine Triphosphate
  • Laccase
ispartof: PloS one, 2017, Vol.12(11), p.e0187351
description: Mechanical damage can induce fruiting body production in fungi. In this study, the antioxidant kojic acid (KA) was found to enhance injured mycelial regeneration and increase fruiting body production in Hypsizygus marmoreus. KA reduced the level of reactive oxygen species (ROS), which are harmful to mycelia when excessively generated by mechanical damage. Moreover, KA increased catalase and superoxide dismutase activities and glutathione and ascorbic acid contents by up-regulating antioxidant gene expression. These results suggest that KA promotes mycelial regeneration in response to damage by activating a "stress signal" and enhances the ability of H. marmoreus to resist oxidative damage by invoking the antioxidant system. In addition, KA increased the content of extracellular ATP, which serves as a "stress signal" in response to injury, and modulated ROS signaling, decreasing NADPH oxidase gene expression and ROS levels in the mycelial-regeneration stage. KA treatment also up-regulated the MAPK, Ca.sup.2+ and oxylipin pathways, suggesting their involvement in the damage response. Furthermore, laccase and cellulase activities were stimulated by KA at different developmental stages. These results demonstrate that KA regulates gene expression and activates pathways for mycelial wound healing, regeneration of damaged mycelia and reproductive structure formation in the basidiomycete H. marmoreus.
language: eng
source:
identifier: E-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0187351
fulltext: fulltext
issn:
  • 19326203
  • 1932-6203
url: Link


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titleKojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus.
creatorZhang, Jinjing ; Chen, Hui ; Chen, Mingjie ; Wang, Hong ; Wang, Qian ; Song, Xiaoxia ; Hao, Haibo ; Feng, Zhiyong
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identifierE-ISSN: 1932-6203 ; DOI: 10.1371/journal.pone.0187351
subjectAdenosine Triphosphate–Metabolism ; Antioxidants–Metabolism ; Basidiomycota–Drug Effects ; Cluster Analysis–Genetics ; Fruiting Bodies, Fungal–Physiology ; Gene Expression Profiling–Drug Effects ; Gene Expression Regulation, Fungal–Physiology ; Laccase–Drug Effects ; Models, Biological–Genetics ; Molecular Sequence Annotation–Metabolism ; Mycelium–Drug Effects ; Pyrones–Physiology ; Reactive Oxygen Species–Pharmacology ; Regeneration–Metabolism ; Sequence Analysis, RNA–Drug Effects ; Signal Transduction–Drug Effects ; Transcriptome–Genetics ; Transcriptome–Genetics ; Antioxidants ; Pyrones ; Reactive Oxygen Species ; Kojic Acid ; Adenosine Triphosphate ; Laccase
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descriptionMechanical damage can induce fruiting body production in fungi. In this study, the antioxidant kojic acid (KA) was found to enhance injured mycelial regeneration and increase fruiting body production in Hypsizygus marmoreus. KA reduced the level of reactive oxygen species (ROS), which are harmful to mycelia when excessively generated by mechanical damage. Moreover, KA increased catalase and superoxide dismutase activities and glutathione and ascorbic acid contents by up-regulating antioxidant gene expression. These results suggest that KA promotes mycelial regeneration in response to damage by activating a "stress signal" and enhances the ability of H. marmoreus to resist oxidative damage by invoking the antioxidant system. In addition, KA increased the content of extracellular ATP, which serves as a "stress signal" in response to injury, and modulated ROS signaling, decreasing NADPH oxidase gene expression and ROS levels in the mycelial-regeneration stage. KA treatment also up-regulated the MAPK, Ca.sup.2+ and oxylipin pathways, suggesting their involvement in the damage response. Furthermore, laccase and cellulase activities were stimulated by KA at different developmental stages. These results demonstrate that KA regulates gene expression and activates pathways for mycelial wound healing, regeneration of damaged mycelia and reproductive structure formation in the basidiomycete H. marmoreus.
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titleKojic acid-mediated damage responses induce mycelial regeneration in the basidiomycete Hypsizygus marmoreus.
authorZhang, Jinjing ; Chen, Hui ; Chen, Mingjie ; Wang, Hong ; Wang, Qian ; Song, Xiaoxia ; Hao, Haibo ; Feng, Zhiyong
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