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Gastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?

Introduction We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. Background Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, ind... Full description

Journal Title: Mycopathologia Dec 2017, Vol.182(11-12), pp.1125-1129
Main Author: Gamaletsou, Maria
Other Authors: Denning, David
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0301486X ; E-ISSN: 15730832 ; DOI: 10.1007/s11046-017-0176-y
Link: http://search.proquest.com/docview/1963349761/?pq-origsite=primo
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title: Gastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?
format: Article
creator:
  • Gamaletsou, Maria
  • Denning, David
subjects:
  • Obstructive Lung Disease
  • Markers
  • Fungicides
  • Medical Research
  • Endoscopy
  • Males
  • Patients
  • Pain
  • Ulcers
  • Medical Services
  • Bronchitis
  • Chronic Obstructive Pulmonary Disease
  • Smoking
  • Surgery
  • Aspergillosis
  • Lung Diseases
  • Ph Effects
  • Immunoglobulin G
  • Immunoglobulin E
  • Immunoglobulins
  • Laryngoscopy
  • Females
  • Pain
  • Nausea
  • Respiration
  • Antibodies
  • Asthma
  • Medical Research
  • Bronchitis
  • Lung
  • Asthma
  • Nausea
  • Dyspnea
  • Dyspnea
  • Gastroesophageal Reflux
  • Serology
  • Gastroesophageal Reflux
  • Esophagus
  • Endoscopes
  • Inflammation
  • Asthma
  • Esophagus
  • Sputum
  • Alcohol
  • Medical Records
  • Smoking
  • Allergic Bronchopulmonary Aspergillosis
  • Ulcers
  • Medical Instruments
  • Pain
  • Gastroesophageal Reflux
  • Aspergilluslung Disease
ispartof: Mycopathologia, Dec 2017, Vol.182(11-12), pp.1125-1129
description: Introduction We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. Background Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. Methods We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD. Data were collected retrospectively from medical records included age, gender, predisposing factors for ABPA, chronic pulmonary aspergillosis, or Aspergillus bronchitis; presence of nocturnal reflux, nausea, epigastric pain, Medical Research Council dyspnea scale score, pH manometry data, endoscopic results (ulcers, Barrett’s esophagus), treatment of GORD [proton-pump inhibitors (PPIs), surgical operation]; history of smoking, alcohol consumption; concomitant COPD; serological markers (anti-Aspergillus IgG, anti-Aspergillus IgE), and antifungal treatment. Results Four patients with GORD were studied; following PPIs administration two achieved clinical improvement. One had ABPA, one CPA, and two had Aspergillus bronchitis; median age was 57 years [range 39–71]; males-to-females ratio was 1:3. Serological markers for aspergillosis were: median total IgE antibodies 573 KIU/L [range 13.1–850], median Aspergillus IgE-specific antibodies 1.2 kAU/L [range
language: eng
source:
identifier: ISSN: 0301486X ; E-ISSN: 15730832 ; DOI: 10.1007/s11046-017-0176-y
fulltext: fulltext
issn:
  • 0301486X
  • 0301-486X
  • 15730832
  • 1573-0832
url: Link


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titleGastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?
creatorGamaletsou, Maria ; Denning, David
ispartofMycopathologia, Dec 2017, Vol.182(11-12), pp.1125-1129
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subjectObstructive Lung Disease ; Markers ; Fungicides ; Medical Research ; Endoscopy ; Males ; Patients ; Pain ; Ulcers ; Medical Services ; Bronchitis ; Chronic Obstructive Pulmonary Disease ; Smoking ; Surgery ; Aspergillosis ; Lung Diseases ; Ph Effects ; Immunoglobulin G ; Immunoglobulin E ; Immunoglobulins ; Laryngoscopy ; Females ; Pain ; Nausea ; Respiration ; Antibodies ; Asthma ; Medical Research ; Bronchitis ; Lung ; Asthma ; Nausea ; Dyspnea ; Dyspnea ; Gastroesophageal Reflux ; Serology ; Gastroesophageal Reflux ; Esophagus ; Endoscopes ; Inflammation ; Asthma ; Esophagus ; Sputum ; Alcohol ; Medical Records ; Smoking ; Allergic Bronchopulmonary Aspergillosis ; Ulcers ; Medical Instruments ; Pain ; Gastroesophageal Reflux ; Aspergilluslung Disease
descriptionIntroduction We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. Background Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. Methods We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD. Data were collected retrospectively from medical records included age, gender, predisposing factors for ABPA, chronic pulmonary aspergillosis, or Aspergillus bronchitis; presence of nocturnal reflux, nausea, epigastric pain, Medical Research Council dyspnea scale score, pH manometry data, endoscopic results (ulcers, Barrett’s esophagus), treatment of GORD [proton-pump inhibitors (PPIs), surgical operation]; history of smoking, alcohol consumption; concomitant COPD; serological markers (anti-Aspergillus IgG, anti-Aspergillus IgE), and antifungal treatment. Results Four patients with GORD were studied; following PPIs administration two achieved clinical improvement. One had ABPA, one CPA, and two had Aspergillus bronchitis; median age was 57 years [range 39–71]; males-to-females ratio was 1:3. Serological markers for aspergillosis were: median total IgE antibodies 573 KIU/L [range 13.1–850], median Aspergillus IgE-specific antibodies 1.2 kAU/L [range <0.4–24.7], and median Aspergillus IgG titers 71 mg/L [range 20–119]. Aspergillus fumigatus grew in one sputum sample. Conclusion Clinicians caring for patients with gastroesophageal reflux disease presenting with elevated Aspergillus IgG or IgE antibodies should maintain a high index of suspicion for this association and proceed to appropriate evaluations, including laryngoscopy and endoscopy, initiating specific PPI-directed therapy when indicated.
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titleGastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?
descriptionIntroduction We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. Background Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. Methods We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD. Data were collected retrospectively from medical records included age, gender, predisposing factors for ABPA, chronic pulmonary aspergillosis, or Aspergillus bronchitis; presence of nocturnal reflux, nausea, epigastric pain, Medical Research Council dyspnea scale score, pH manometry data, endoscopic results (ulcers, Barrett’s esophagus), treatment of GORD [proton-pump inhibitors (PPIs), surgical operation]; history of smoking, alcohol consumption; concomitant COPD; serological markers (anti-Aspergillus IgG, anti-Aspergillus IgE), and antifungal treatment. Results Four patients with GORD were studied; following PPIs administration two achieved clinical improvement. One had ABPA, one CPA, and two had Aspergillus bronchitis; median age was 57 years [range 39–71]; males-to-females ratio was 1:3. Serological markers for aspergillosis were: median total IgE antibodies 573 KIU/L [range 13.1–850], median Aspergillus IgE-specific antibodies 1.2 kAU/L [range <0.4–24.7], and median Aspergillus IgG titers 71 mg/L [range 20–119]. Aspergillus fumigatus grew in one sputum sample. Conclusion Clinicians caring for patients with gastroesophageal reflux disease presenting with elevated Aspergillus IgG or IgE antibodies should maintain a high index of suspicion for this association and proceed to appropriate evaluations, including laryngoscopy and endoscopy, initiating specific PPI-directed therapy when indicated.
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29Serology
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31Endoscopes
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37Medical Instruments
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titleGastroesophageal Reflux Disease and Pulmonary Diseases Associated with Aspergillosis: Is There a Connection?
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4Endoscopy
5Males
6Patients
7Pain
8Ulcers
9Medical Services
10Bronchitis
11Chronic Obstructive Pulmonary Disease
12Smoking
13Surgery
14Aspergillosis
15Lung Diseases
16Ph Effects
17Immunoglobulin G
18Immunoglobulin E
19Immunoglobulins
20Laryngoscopy
21Females
22Nausea
23Respiration
24Antibodies
25Asthma
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abstractIntroduction We studied the relationship between GORD and allergic bronchopulmonary aspergillosis (ABPA), chronic pulmonary aspergillosis (CPA), or Aspergillus bronchitis. Background Gastroesophageal reflux disease (GORD) is well known to initiate or exacerbate pulmonary inflammatory conditions, inducing bronchial asthma and chronic obstructive lung disease. Methods We reviewed four patients referred with elevated Aspergillus serology markers and marked pulmonary symptoms for ABPA, CPA, and Aspergillus bronchitis, and discussed the underlying pathophysiological relationship with GORD. Data were collected retrospectively from medical records included age, gender, predisposing factors for ABPA, chronic pulmonary aspergillosis, or Aspergillus bronchitis; presence of nocturnal reflux, nausea, epigastric pain, Medical Research Council dyspnea scale score, pH manometry data, endoscopic results (ulcers, Barrett’s esophagus), treatment of GORD [proton-pump inhibitors (PPIs), surgical operation]; history of smoking, alcohol consumption; concomitant COPD; serological markers (anti-Aspergillus IgG, anti-Aspergillus IgE), and antifungal treatment. Results Four patients with GORD were studied; following PPIs administration two achieved clinical improvement. One had ABPA, one CPA, and two had Aspergillus bronchitis; median age was 57 years [range 39–71]; males-to-females ratio was 1:3. Serological markers for aspergillosis were: median total IgE antibodies 573 KIU/L [range 13.1–850], median Aspergillus IgE-specific antibodies 1.2 kAU/L [range <0.4–24.7], and median Aspergillus IgG titers 71 mg/L [range 20–119]. Aspergillus fumigatus grew in one sputum sample. Conclusion Clinicians caring for patients with gastroesophageal reflux disease presenting with elevated Aspergillus IgG or IgE antibodies should maintain a high index of suspicion for this association and proceed to appropriate evaluations, including laryngoscopy and endoscopy, initiating specific PPI-directed therapy when indicated.
copDordrecht
pubSpringer Science & Business Media
doi10.1007/s11046-017-0176-y
urlhttp://search.proquest.com/docview/1963349761/
date2017-12-01