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Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.

Circular RNAs (circRNAs) as a novel type of noncoding RNAs (ncRNAs) are widely studied in the development of human various diseases, including cancer. Here, we found circular RNA hsa_circ_000984 encoded by the CDK6 gene was remarkably upregulated in the tissues of colorectal cancer (CRC) patients an... Full description

Journal Title: Oncotarget October 31, 2017, Vol.8(53), pp.91674-91683
Main Author: Xu, Xiao-Wu
Other Authors: Zheng, Bo-An , Hu, Zhi-Ming , Qian, Zhen-Yuan , Huang, Chao-Jie , Liu, Xi-Qiang , Wu, Wei-Ding
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.21748
Link: http://search.proquest.com/docview/1973456355/?pq-origsite=primo
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recordid: proquest1973456355
title: Circular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.
format: Article
creator:
  • Xu, Xiao-Wu
  • Zheng, Bo-An
  • Hu, Zhi-Ming
  • Qian, Zhen-Yuan
  • Huang, Chao-Jie
  • Liu, Xi-Qiang
  • Wu, Wei-Ding
subjects:
  • Circular RNA
  • Colon Cancer
  • Growth
  • Hsa_Circ_000984
  • Mir-106b
ispartof: Oncotarget, October 31, 2017, Vol.8(53), pp.91674-91683
description: Circular RNAs (circRNAs) as a novel type of noncoding RNAs (ncRNAs) are widely studied in the development of human various diseases, including cancer. Here, we found circular RNA hsa_circ_000984 encoded by the CDK6 gene was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines. Moreover, high expression level of hsa_circ_000984 was significantly associated with advanced colorectal cancer. Further analysis revealed that hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in CRC cell lines. Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR-106b and effectively upregulate the expression of CDK6 , thereby inducing a series of malignant phenotypes of tumor cells. Taken together, these observations suggest that the hsa_circ_000984 could mediate the expression of gene CDK6 by acting as a ceRNA, which may contribute to a better understanding of between the regulatory miRNA network and CRC pathogenesis.
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.21748
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleCircular RNA hsa_circ_000984 promotes colon cancer growth and metastasis by sponging miR-106b.
creatorXu, Xiao-Wu ; Zheng, Bo-An ; Hu, Zhi-Ming ; Qian, Zhen-Yuan ; Huang, Chao-Jie ; Liu, Xi-Qiang ; Wu, Wei-Ding
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ispartofOncotarget, October 31, 2017, Vol.8(53), pp.91674-91683
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.21748
subjectCircular RNA ; Colon Cancer ; Growth ; Hsa_Circ_000984 ; Mir-106b
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descriptionCircular RNAs (circRNAs) as a novel type of noncoding RNAs (ncRNAs) are widely studied in the development of human various diseases, including cancer. Here, we found circular RNA hsa_circ_000984 encoded by the CDK6 gene was remarkably upregulated in the tissues of colorectal cancer (CRC) patients and in the CRC cell lines. Moreover, high expression level of hsa_circ_000984 was significantly associated with advanced colorectal cancer. Further analysis revealed that hsa_circ_000984 knockdown could inhibit cell proliferation, migration, invasion in vitro and tumor formation in vivo in CRC cell lines. Mechanically, we found that hsa_circ_000984 may act as a competing endogenous RNA (ceRNA) by competitively binding miR-106b and effectively upregulate the expression of CDK6 , thereby inducing a series of malignant phenotypes of tumor cells. Taken together, these observations suggest that the hsa_circ_000984 could mediate the expression of gene CDK6 by acting as a ceRNA, which may contribute to a better understanding of between the regulatory miRNA network and CRC pathogenesis.
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