schliessen

Filtern

 

Bibliotheken

Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.

The aim of this study is to develop a novel RGD and TAT co-modified docetaxel (DTX)-loaded liposome (LP) by the emulsification-solvent evaporation method. The prepared LPs were found to be in the size of 100 nm-110 nm. The transmission electron microscope photomicrographs were smooth, sub-spherical... Full description

Journal Title: Drug design development and therapy, 2017, Vol.11, pp.3481-3489
Main Author: Zhu, Ren
Other Authors: Tian, Ye
Format: Electronic Article Electronic Article
Language: English
Subjects:
Rgd
TAT
ID: E-ISSN: 1177-8881 ; DOI: 10.2147/DDDT.S149620
Link: http://search.proquest.com/docview/1978713594/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1978713594
title: Preparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.
format: Article
creator:
  • Zhu, Ren
  • Tian, Ye
subjects:
  • Animals–Administration & Dosage
  • Antineoplastic Agents–Pharmacology
  • Cell Line, Tumor–Drug Effects
  • Cell Proliferation–Drug Therapy
  • Docetaxel–Pathology
  • Dose-Response Relationship, Drug–Chemistry
  • Drug Delivery Systems–Administration & Dosage
  • Humans–Pharmacology
  • Liposomes–Pharmacology
  • Mice–Pharmacology
  • Mice, Inbred Balb C–Pharmacology
  • Mice, Nude–Pharmacology
  • Neoplasms, Experimental–Pharmacology
  • Oligopeptides–Pharmacology
  • Particle Size–Pharmacology
  • Structure-Activity Relationship–Pharmacology
  • Surface Properties–Pharmacology
  • Taxoids–Pharmacology
  • Transcriptional Activation–Pharmacology
  • Antineoplastic Agents
  • Liposomes
  • Oligopeptides
  • Taxoids
  • Docetaxel
  • Arginyl-Glycyl-Aspartic Acid
  • Rgd
  • TAT
  • Antitumor
  • Cell Uptake
  • Cytotoxicity
  • Liposome
ispartof: Drug design, development and therapy, 2017, Vol.11, pp.3481-3489
description: The aim of this study is to develop a novel RGD and TAT co-modified docetaxel (DTX)-loaded liposome (LP) by the emulsification-solvent evaporation method. The prepared LPs were found to be in the size of 100 nm-110 nm. The transmission electron microscope photomicrographs were smooth, sub-spherical in shape, and aggregated to form small clusters. The DTX cumulative release from TAT and RGD co-modified LPs was significantly higher than that from other LPs due to decreased diffusion distance. Results of cell uptake showed that surface modification could indicate when cell internalization was changed and more drugs entered the cells successfully. Surprisingly, TAT and RGD co-modified DTX-LPs demonstrated a superior antiproliferative effect on A549 cells with a possible mechanism that suppressed the multidrug resistance phenomenon and exhibited a clear synergistic effect. In antitumor study, our results indicated that the form of TAT and RGD co-modified LPs had a better antitumor effect in vivo than the other formulations. Keywords: RGD, TAT, liposome, cell uptake, cytotoxicity, antitumor
language: eng
source:
identifier: E-ISSN: 1177-8881 ; DOI: 10.2147/DDDT.S149620
fulltext: fulltext
issn:
  • 11778881
  • 1177-8881
url: Link


@attributes
ID983259312
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1978713594
sourceidproquest
recordidTN_proquest1978713594
sourcesystemPC
pqid1978713594
galeid531884886
display
typearticle
titlePreparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.
creatorZhu, Ren ; Tian, Ye
contributorZhu, Ren (correspondence author) ; Zhu, Ren (record owner)
ispartofDrug design, development and therapy, 2017, Vol.11, pp.3481-3489
identifierE-ISSN: 1177-8881 ; DOI: 10.2147/DDDT.S149620
subjectAnimals–Administration & Dosage ; Antineoplastic Agents–Pharmacology ; Cell Line, Tumor–Drug Effects ; Cell Proliferation–Drug Therapy ; Docetaxel–Pathology ; Dose-Response Relationship, Drug–Chemistry ; Drug Delivery Systems–Administration & Dosage ; Humans–Pharmacology ; Liposomes–Pharmacology ; Mice–Pharmacology ; Mice, Inbred Balb C–Pharmacology ; Mice, Nude–Pharmacology ; Neoplasms, Experimental–Pharmacology ; Oligopeptides–Pharmacology ; Particle Size–Pharmacology ; Structure-Activity Relationship–Pharmacology ; Surface Properties–Pharmacology ; Taxoids–Pharmacology ; Transcriptional Activation–Pharmacology ; Antineoplastic Agents ; Liposomes ; Oligopeptides ; Taxoids ; Docetaxel ; Arginyl-Glycyl-Aspartic Acid ; Rgd ; TAT ; Antitumor ; Cell Uptake ; Cytotoxicity ; Liposome
languageeng
source
descriptionThe aim of this study is to develop a novel RGD and TAT co-modified docetaxel (DTX)-loaded liposome (LP) by the emulsification-solvent evaporation method. The prepared LPs were found to be in the size of 100 nm-110 nm. The transmission electron microscope photomicrographs were smooth, sub-spherical in shape, and aggregated to form small clusters. The DTX cumulative release from TAT and RGD co-modified LPs was significantly higher than that from other LPs due to decreased diffusion distance. Results of cell uptake showed that surface modification could indicate when cell internalization was changed and more drugs entered the cells successfully. Surprisingly, TAT and RGD co-modified DTX-LPs demonstrated a superior antiproliferative effect on A549 cells with a possible mechanism that suppressed the multidrug resistance phenomenon and exhibited a clear synergistic effect. In antitumor study, our results indicated that the form of TAT and RGD co-modified LPs had a better antitumor effect in vivo than the other formulations. Keywords: RGD, TAT, liposome, cell uptake, cytotoxicity, antitumor
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1978713594/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Zhu, Ren
1Tian, Ye
titlePreparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.
subject
0Animals–Administration & Dosage
1Antineoplastic Agents–Pharmacology
2Cell Line, Tumor–Drug Effects
3Cell Proliferation–Drug Therapy
4Docetaxel–Pathology
5Dose-Response Relationship, Drug–Chemistry
6Drug Delivery Systems–Administration & Dosage
7Humans–Pharmacology
8Liposomes–Pharmacology
9Mice–Pharmacology...
10RGD
11TAT
12antitumor
13cell uptake
14cytotoxicity
15liposome
general
0English
110.2147/DDDT.S149620
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1978713594
issn
011778881
11177-8881
rsrctypearticle
creationdate2017
addtitleDrug design, development and therapy
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorZhu, Ren
startdate20170101
enddate20170101
citationpf 3481 pt 3489 vol 11
lsr30VSR-Enriched:[pqid, galeid, description]
sort
titlePreparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.
authorZhu, Ren ; Tian, Ye
creationdate20170101
lso0120170101
facets
frbrgroupid8452364973938693446
frbrtype5
newrecords20181218
languageeng
creationdate2017
topic
0Animals–Administration & Dosage
1Antineoplastic Agents–Pharmacology
2Cell Line, Tumor–Drug Effects
3Cell Proliferation–Drug Therapy
4Docetaxel–Pathology
5Dose-Response Relationship, Drug–Chemistry
6Drug Delivery Systems–Administration & Dosage
7Humans–Pharmacology
8Liposomes–Pharmacology
9Mice–Pharmacology...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Zhu, Ren
1Tian, Ye
jtitleDrug design, development and therapy
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Zhu
1Tian
aufirst
0Ren
1Ye
au
0Zhu, Ren
1Tian, Ye
addauZhu, Ren
atitlePreparation and evaluation of RGD and TAT co-modified docetaxel-loaded liposome.
jtitleDrug design, development and therapy
risdate20170101
volume11
spage3481
epage3489
pages3481-3489
eissn1177-8881
formatjournal
genrearticle
ristypeJOUR
doi10.2147/DDDT.S149620
urlhttp://search.proquest.com/docview/1978713594/
date2017-01-01