schliessen

Filtern

 

Bibliotheken

Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.

The growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is tra... Full description

Journal Title: The Journal of veterinary medical science February 9, 2018, Vol.80(2), pp.235-241
Main Author: Nagamachi, Satsuki
Other Authors: Nishigawa, Takuma , Takakura, Mayumi , Ikeda, Hiromi , Kodaira, Momoko , Yamaguchi, Takeshi , Chowdhury, Vishwajit Sur , Yasuo, Shinobu , Furuse, Mitsuhiro
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1347-7439 ; DOI: 10.1292/jvms.17-0577
Link: http://search.proquest.com/docview/1979965366/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest1979965366
title: Dietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
format: Article
creator:
  • Nagamachi, Satsuki
  • Nishigawa, Takuma
  • Takakura, Mayumi
  • Ikeda, Hiromi
  • Kodaira, Momoko
  • Yamaguchi, Takeshi
  • Chowdhury, Vishwajit Sur
  • Yasuo, Shinobu
  • Furuse, Mitsuhiro
subjects:
  • Amino Acids–Analysis
  • Animals–Blood
  • Animals, Newborn–Blood
  • Behavior, Animal–Growth & Development
  • Body Weight–Drug Effects
  • Diet–Drug Effects
  • Female–Drug Effects
  • Lactation–Chemistry
  • Male–Pharmacology
  • Mice–Pharmacology
  • Mice, Inbred Icr–Pharmacology
  • Milk–Pharmacology
  • Pregnancy–Pharmacology
  • Serine–Pharmacology
  • Amino Acids
  • Serine
  • L-Serine
  • Free Amino Acid
  • Growth
  • Maternal Milk
  • Mouse
ispartof: The Journal of veterinary medical science, February 9, 2018, Vol.80(2), pp.235-241
description: The growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.
language: eng
source:
identifier: E-ISSN: 1347-7439 ; DOI: 10.1292/jvms.17-0577
fulltext: fulltext
issn:
  • 13477439
  • 1347-7439
url: Link


@attributes
ID1350851484
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid1979965366
sourceidproquest
recordidTN_proquest1979965366
sourcesystemPC
pqid1979965366
display
typearticle
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
creatorNagamachi, Satsuki ; Nishigawa, Takuma ; Takakura, Mayumi ; Ikeda, Hiromi ; Kodaira, Momoko ; Yamaguchi, Takeshi ; Chowdhury, Vishwajit Sur ; Yasuo, Shinobu ; Furuse, Mitsuhiro
contributorNagamachi, Satsuki (correspondence author) ; Nagamachi, Satsuki (record owner)
ispartofThe Journal of veterinary medical science, February 9, 2018, Vol.80(2), pp.235-241
identifierE-ISSN: 1347-7439 ; DOI: 10.1292/jvms.17-0577
subjectAmino Acids–Analysis ; Animals–Blood ; Animals, Newborn–Blood ; Behavior, Animal–Growth & Development ; Body Weight–Drug Effects ; Diet–Drug Effects ; Female–Drug Effects ; Lactation–Chemistry ; Male–Pharmacology ; Mice–Pharmacology ; Mice, Inbred Icr–Pharmacology ; Milk–Pharmacology ; Pregnancy–Pharmacology ; Serine–Pharmacology ; Amino Acids ; Serine ; L-Serine ; Free Amino Acid ; Growth ; Maternal Milk ; Mouse
languageeng
source
description

The growth of offspring is affected not only by the protein in maternal milk but also by the free amino acids (FAAs) contained in it. L-Serine (L-Ser) is known as an important FAA for the development of the central nervous system and behavioral activity. However, it is not clear whether L-Ser is transported into the pool of FAAs contained in milk and thereby affects the growth of offspring. Using mice, the current study investigated the effects of dietary L-Ser during pregnancy and lactation on milk and plasma FAA composition, as well as on growth, behavior, and plasma FAAs of offspring. Dietary L-Ser did not significantly affect the maternal, anxiety-like, or cognitive behaviors of either the dam or the offspring. The FAA composition notably differed between plasma and milk in dams. In milk, dietary L-Ser increased free L-Ser levels, while glutamic acid, L-alanine, D-alanine and taurine levels were decreased. The body weight of the offspring was lowered by dietary L-Ser. The concentrations of plasma FAAs in 13-day-old offspring (fed only milk) were not altered, but 20-day-old offspring (fed both milk and parental diet) showed higher plasma L-Ser and D-Ser concentrations as a result of the dietary L-Ser treatment. In conclusion, the present study found that dietary L-Ser transported easily from maternal plasma to milk and that dietary L-Ser treatment could change the FAA composition of milk, but that an enhanced level of L-Ser in milk did not enhance the plasma L-Ser level in the offspring.

version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/1979965366/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
subject
0Amino Acids–Analysis
1Animals–Blood
2Animals, Newborn–Blood
3Behavior, Animal–Growth & Development
4Body Weight–Drug Effects
5Diet–Drug Effects
6Female–Drug Effects
7Lactation–Chemistry
8Male–Pharmacology
9Mice–Pharmacology
10Mice, Inbred Icr–Pharmacology...
11L-serine
12free amino acid
13growth
14maternal milk
15mouse
general
0English
110.1292/jvms.17-0577
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest1979965366
issn
013477439
11347-7439
rsrctypearticle
creationdate2018
addtitleThe Journal of veterinary medical science
searchscope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
scope
01007527
11007944
21009130
310000004
410000038
510000050
610000120
710000159
810000238
910000253
1010000260
1110000270
1210000271
1310000302
1410000350
15proquest
lsr43
01007527false
11007944false
21009130false
310000004false
410000038false
510000050false
610000120false
710000159false
810000238false
910000253false
1010000260false
1110000270false
1210000271false
1310000302false
1410000350false
contributorNagamachi, Satsuki
startdate20180209
enddate20180209
citationpf 235 pt 241 vol 80 issue 2
lsr30VSR-Enriched:[pqid, description, issn]
sort
titleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
authorNagamachi, Satsuki ; Nishigawa, Takuma ; Takakura, Mayumi ; Ikeda, Hiromi ; Kodaira, Momoko ; Yamaguchi, Takeshi ; Chowdhury, Vishwajit Sur ; Yasuo, Shinobu ; Furuse, Mitsuhiro
creationdate20180209
lso0120180209
facets
frbrgroupid-2343681073777935316
frbrtype5
newrecords20181218
languageeng
creationdate2018
topic
0Amino Acids–Analysis
1Animals–Blood
2Animals, Newborn–Blood
3Behavior, Animal–Growth & Development
4Body Weight–Drug Effects
5Diet–Drug Effects
6Female–Drug Effects
7Lactation–Chemistry
8Male–Pharmacology
9Mice–Pharmacology
10Mice, Inbred Icr–Pharmacology...
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
jtitleJournal of veterinary medical science
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Nagamachi
1Nishigawa
2Takakura
3Ikeda
4Kodaira
5Yamaguchi
6Chowdhury
7Yasuo
8Furuse
aufirst
0Satsuki
1Takuma
2Mayumi
3Hiromi
4Momoko
5Takeshi
6Vishwajit Sur
7Shinobu
8Mitsuhiro
au
0Nagamachi, Satsuki
1Nishigawa, Takuma
2Takakura, Mayumi
3Ikeda, Hiromi
4Kodaira, Momoko
5Yamaguchi, Takeshi
6Chowdhury, Vishwajit Sur
7Yasuo, Shinobu
8Furuse, Mitsuhiro
addauNagamachi, Satsuki
atitleDietary L-serine modifies free amino acid composition of maternal milk and lowers the body weight of the offspring in mice.
jtitleThe Journal of veterinary medical science
risdate20180209
volume80
issue2
spage235
epage241
pages235-241
eissn1347-7439
formatjournal
genrearticle
ristypeJOUR
doi10.1292/jvms.17-0577
urlhttp://search.proquest.com/docview/1979965366/
issn09167250
date2018-02-09