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Sibling risks of abdominal aortic aneurysm

There is evidence that the risk of abdominal aortic aneurysm (AAA) is greater in first-degree relatives of patients with the disorder than in the same age group of the general population. We conducted a 3-year study of siblings of AAA probands and siblings of a control group (cataract surgery patien... Full description

Journal Title: The Lancet Sep 2, 1995, Vol.346(8975), pp.601-4
Main Author: Baird, P
Other Authors: Sadovnick, A , Yee, I , Cole, C , Cole, L
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 01406736 ; E-ISSN: 1474547X ; DOI: 10.1016/S0140-6736(95)91436-6
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recordid: proquest198971627
title: Sibling risks of abdominal aortic aneurysm
format: Article
creator:
  • Baird, P
  • Sadovnick, A
  • Yee, I
  • Cole, C
  • Cole, L
subjects:
  • Age Factors–Genetics
  • Aged–Ultrasonography
  • Aged, 80 & Over–Ultrasonography
  • Aortic Aneurysm, Abdominal–Ultrasonography
  • Aortic Aneurysm, Abdominal–Ultrasonography
  • Case-Control Studies–Ultrasonography
  • Female–Ultrasonography
  • Humans–Ultrasonography
  • Male–Ultrasonography
  • Middle Aged–Ultrasonography
  • Nuclear Family–Ultrasonography
  • Risk Factors–Ultrasonography
  • Sex Factors–Ultrasonography
  • Ultrasonic Imaging
  • Siblings
  • Medical Research
  • Medical Disorders
  • Coronary Vessels
ispartof: The Lancet, Sep 2, 1995, Vol.346(8975), pp.601-4
description: There is evidence that the risk of abdominal aortic aneurysm (AAA) is greater in first-degree relatives of patients with the disorder than in the same age group of the general population. We conducted a 3-year study of siblings of AAA probands and siblings of a control group (cataract surgery patients) of the same age. Genetic information was obtained by interview from 126 probands and 100 controls; another family member was present at the interview. Medical records were obtained and further information verified before a sibling (over age 50) was assigned affected status. Of 427 siblings of probands, 19 (4.4%) had probable or definite AAA, compared with five (1.1%) of 451 siblings of controls. The lifetime cumulative risks of AAA at age 83 were 11.7% (SD 3.1) and 7.5% (4.1), respectively. The risk of AAA began at an earlier age and increased more rapidly for probands' siblings than for controls' siblings (p < 0.01, log-rank test). A risk comparison, based on the results of ultrasound screening...
language: eng
source:
identifier: ISSN: 01406736 ; E-ISSN: 1474547X ; DOI: 10.1016/S0140-6736(95)91436-6
fulltext: fulltext
issn:
  • 01406736
  • 0140-6736
  • 1474547X
  • 1474-547X
url: Link


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titleSibling risks of abdominal aortic aneurysm
creatorBaird, P ; Sadovnick, A ; Yee, I ; Cole, C ; Cole, L
ispartofThe Lancet, Sep 2, 1995, Vol.346(8975), pp.601-4
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subjectAge Factors–Genetics ; Aged–Ultrasonography ; Aged, 80 & Over–Ultrasonography ; Aortic Aneurysm, Abdominal–Ultrasonography ; Aortic Aneurysm, Abdominal–Ultrasonography ; Case-Control Studies–Ultrasonography ; Female–Ultrasonography ; Humans–Ultrasonography ; Male–Ultrasonography ; Middle Aged–Ultrasonography ; Nuclear Family–Ultrasonography ; Risk Factors–Ultrasonography ; Sex Factors–Ultrasonography ; Ultrasonic Imaging ; Siblings ; Medical Research ; Medical Disorders ; Coronary Vessels
descriptionThere is evidence that the risk of abdominal aortic aneurysm (AAA) is greater in first-degree relatives of patients with the disorder than in the same age group of the general population. We conducted a 3-year study of siblings of AAA probands and siblings of a control group (cataract surgery patients) of the same age. Genetic information was obtained by interview from 126 probands and 100 controls; another family member was present at the interview. Medical records were obtained and further information verified before a sibling (over age 50) was assigned affected status. Of 427 siblings of probands, 19 (4.4%) had probable or definite AAA, compared with five (1.1%) of 451 siblings of controls. The lifetime cumulative risks of AAA at age 83 were 11.7% (SD 3.1) and 7.5% (4.1), respectively. The risk of AAA began at an earlier age and increased more rapidly for probands' siblings than for controls' siblings (p < 0.01, log-rank test). A risk comparison, based on the results of ultrasound screening...
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titleSibling risks of abdominal aortic aneurysm
descriptionThere is evidence that the risk of abdominal aortic aneurysm (AAA) is greater in first-degree relatives of patients with the disorder than in the same age group of the general population. We conducted a 3-year study of siblings of AAA probands and siblings of a control group (cataract surgery patients) of the same age. Genetic information was obtained by interview from 126 probands and 100 controls; another family member was present at the interview. Medical records were obtained and further information verified before a sibling (over age 50) was assigned affected status. Of 427 siblings of probands, 19 (4.4%) had probable or definite AAA, compared with five (1.1%) of 451 siblings of controls. The lifetime cumulative risks of AAA at age 83 were 11.7% (SD 3.1) and 7.5% (4.1), respectively. The risk of AAA began at an earlier age and increased more rapidly for probands' siblings than for controls' siblings (p < 0.01, log-rank test). A risk comparison, based on the results of ultrasound screening...
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titleSibling risks of abdominal aortic aneurysm
authorBaird, P ; Sadovnick, A ; Yee, I ; Cole, C ; Cole, L
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1Aged–Ultrasonography
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3Aortic Aneurysm, Abdominal–Ultrasonography
4Case-Control Studies–Ultrasonography
5Female–Ultrasonography
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abstractThere is evidence that the risk of abdominal aortic aneurysm (AAA) is greater in first-degree relatives of patients with the disorder than in the same age group of the general population. We conducted a 3-year study of siblings of AAA probands and siblings of a control group (cataract surgery patients) of the same age. Genetic information was obtained by interview from 126 probands and 100 controls; another family member was present at the interview. Medical records were obtained and further information verified before a sibling (over age 50) was assigned affected status. Of 427 siblings of probands, 19 (4.4%) had probable or definite AAA, compared with five (1.1%) of 451 siblings of controls. The lifetime cumulative risks of AAA at age 83 were 11.7% (SD 3.1) and 7.5% (4.1), respectively. The risk of AAA began at an earlier age and increased more rapidly for probands' siblings than for controls' siblings (p < 0.01, log-rank test). A risk comparison, based on the results of ultrasound screening...
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pubElsevier Limited
doi10.1016/S0140-6736(95)91436-6
urlhttp://search.proquest.com/docview/198971627/
date1995-09-02