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Human and Rhesus Macaque KIR Haplotypes Defined by Their Transcriptomes.

The killer-cell Ig-like receptors (KIRs) play a central role in the immune recognition in infection, pregnancy, and transplantation through their interactions with MHC class I molecules. KIR genes display abundant copy number variation as well as high levels of polymorphism. As a result, it is chall... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), March 1, 2018, Vol.200(5), pp.1692-1701
Main Author: Bruijnesteijn, Jesse
Other Authors: van Der Wiel, Marit K H , Swelsen, Wendy T N , Otting, Nel , de Vos-Rouweler, Annemiek J M , Elferink, Diënne , Doxiadis, Gaby G , Claas, Frans H J , Lardy, Neubury M , de Groot, Natasja G , Bontrop, Ronald E
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1701480
Link: http://search.proquest.com/docview/1990489112/?pq-origsite=primo
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title: Human and Rhesus Macaque KIR Haplotypes Defined by Their Transcriptomes.
format: Article
creator:
  • Bruijnesteijn, Jesse
  • van Der Wiel, Marit K H
  • Swelsen, Wendy T N
  • Otting, Nel
  • de Vos-Rouweler, Annemiek J M
  • Elferink, Diënne
  • Doxiadis, Gaby G
  • Claas, Frans H J
  • Lardy, Neubury M
  • de Groot, Natasja G
  • Bontrop, Ronald E
subjects:
  • Alleles–Genetics
  • Animals–Genetics
  • DNA Copy Number Variations–Genetics
  • Gene Rearrangement–Methods
  • Haplotypes–Genetics
  • High-Throughput Nucleotide Sequencing–Genetics
  • Histocompatibility Antigens Class I–Genetics
  • Humans–Genetics
  • Macaca Mulatta–Genetics
  • Polymorphism, Genetic–Genetics
  • Receptors, Kir–Genetics
  • Transcriptome–Genetics
  • Abridged
  • Histocompatibility Antigens Class I
  • Receptors, Kir
ispartof: Journal of immunology (Baltimore, Md. : 1950), March 1, 2018, Vol.200(5), pp.1692-1701
description: The killer-cell Ig-like receptors (KIRs) play a central role in the immune recognition in infection, pregnancy, and transplantation through their interactions with MHC class I molecules. KIR genes display abundant copy number variation as well as high levels of polymorphism. As a result, it is challenging to characterize this structurally dynamic region. KIR haplotypes have been analyzed in different species using conventional characterization methods, such as Sanger sequencing and Roche/454 pyrosequencing. However, these methods are time-consuming and often failed to define complete haplotypes, or do not reach allele-level resolution. In addition, most analyses were performed on genomic DNA, and thus were lacking substantial information about transcription and its corresponding modifications. In this paper, we present a single-molecule real-time sequencing approach, using Pacific Biosciences Sequel platform to characterize the KIR transcriptomes in human and rhesus macaque (Macaca mulatta)...
language: eng
source:
identifier: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1701480
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleHuman and Rhesus Macaque KIR Haplotypes Defined by Their Transcriptomes.
creatorBruijnesteijn, Jesse ; van Der Wiel, Marit K H ; Swelsen, Wendy T N ; Otting, Nel ; de Vos-Rouweler, Annemiek J M ; Elferink, Diënne ; Doxiadis, Gaby G ; Claas, Frans H J ; Lardy, Neubury M ; de Groot, Natasja G ; Bontrop, Ronald E
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ispartofJournal of immunology (Baltimore, Md. : 1950), March 1, 2018, Vol.200(5), pp.1692-1701
identifierE-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1701480
subjectAlleles–Genetics ; Animals–Genetics ; DNA Copy Number Variations–Genetics ; Gene Rearrangement–Methods ; Haplotypes–Genetics ; High-Throughput Nucleotide Sequencing–Genetics ; Histocompatibility Antigens Class I–Genetics ; Humans–Genetics ; Macaca Mulatta–Genetics ; Polymorphism, Genetic–Genetics ; Receptors, Kir–Genetics ; Transcriptome–Genetics ; Abridged ; Histocompatibility Antigens Class I ; Receptors, Kir
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descriptionThe killer-cell Ig-like receptors (KIRs) play a central role in the immune recognition in infection, pregnancy, and transplantation through their interactions with MHC class I molecules. KIR genes display abundant copy number variation as well as high levels of polymorphism. As a result, it is challenging to characterize this structurally dynamic region. KIR haplotypes have been analyzed in different species using conventional characterization methods, such as Sanger sequencing and Roche/454 pyrosequencing. However, these methods are time-consuming and often failed to define complete haplotypes, or do not reach allele-level resolution. In addition, most analyses were performed on genomic DNA, and thus were lacking substantial information about transcription and its corresponding modifications. In this paper, we present a single-molecule real-time sequencing approach, using Pacific Biosciences Sequel platform to characterize the KIR transcriptomes in human and rhesus macaque (Macaca mulatta)...
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authorBruijnesteijn, Jesse ; van Der Wiel, Marit K H ; Swelsen, Wendy T N ; Otting, Nel ; de Vos-Rouweler, Annemiek J M ; Elferink, Diënne ; Doxiadis, Gaby G ; Claas, Frans H J ; Lardy, Neubury M ; de Groot, Natasja G ; Bontrop, Ronald E
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