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Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids

DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing th... Full description

Journal Title: Nutrients 2018, Vol.10(1), p.15
Main Author: Arpón, Ana
Other Authors: Milagro, Fermín , Razquin, Cristina , Corella, Dolores , Estruch, Ramón , Fitó, Montserrat , Marti, Amelia , Martínez-Gonzalez, Miguel , Ros, Emilio , Salas-Salvadó, Jordi , Martínez, J
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 20726643 ; DOI: 10.3390/nu10010015
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title: Impact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
format: Article
creator:
  • Arpón, Ana
  • Milagro, Fermín
  • Razquin, Cristina
  • Corella, Dolores
  • Estruch, Ramón
  • Fitó, Montserrat
  • Marti, Amelia
  • Martínez-Gonzalez, Miguel
  • Ros, Emilio
  • Salas-Salvadó, Jordi
  • Martínez, J
subjects:
  • DNA Methylation
  • Blood
  • Diabetes
  • Diet
  • Fatty Acids
  • Methylation
  • Nuts
  • Genes
  • Metabolism
  • Transduction
  • DNA Methylation
  • Fats and Oils
  • Leukocytes
  • Metabolism
  • Diet
  • White Blood Cells
  • Lipids
  • Nuts
  • Signal Transduction
  • Fatty Acids
  • Fatty Acids
  • Cpg Islands
  • Diabetes Mellitus
  • Blood Cells
  • Cardiovascular Diseases
  • Nuts
  • Erythrocytes
  • Lipids
  • Diabetes Mellitus
  • Olive Oil
  • Intervention
  • Methylation
  • Lipids
  • Metabolism
  • Environmental Factors
  • Olive Oil
  • Environmental Factors
  • Diet
  • Health Risks
  • Diabetes Mellitus
  • Deoxyribonucleic Acid–DNA
  • Deoxyribonucleic Acid–DNA
ispartof: Nutrients, 2018, Vol.10(1), p.15
description: DNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group. Methylation was assessed at baseline and at five-year follow-up. Ingenuity pathway analysis showed routes with differentially methylated CpG sites (CpGs) related to intermediate metabolism, diabetes, inflammation, and signal transduction. Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism. Furthermore, cg01081346 was associated with PUFAs intake, showing a role for specific fatty acids on epigenetic modulation. Specific components of MedDiet, particularly nuts and EVOO, were able to induce methylation changes in several PWBCs genes. These changes may have potential benefits in health; especially those changes in genes related to intermediate metabolism, diabetes, inflammation and signal transduction, which may contribute to explain the role of MedDiet and fat quality on health outcomes.
language: eng
source:
identifier: E-ISSN: 20726643 ; DOI: 10.3390/nu10010015
fulltext: fulltext_linktorsrc
issn:
  • 20726643
  • 2072-6643
url: Link


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titleImpact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
creatorArpón, Ana ; Milagro, Fermín ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Fitó, Montserrat ; Marti, Amelia ; Martínez-Gonzalez, Miguel ; Ros, Emilio ; Salas-Salvadó, Jordi ; Martínez, J
ispartofNutrients, 2018, Vol.10(1), p.15
identifierE-ISSN: 20726643 ; DOI: 10.3390/nu10010015
subjectDNA Methylation ; Blood ; Diabetes ; Diet ; Fatty Acids ; Methylation ; Nuts ; Genes ; Metabolism ; Transduction ; DNA Methylation ; Fats and Oils ; Leukocytes ; Metabolism ; Diet ; White Blood Cells ; Lipids ; Nuts ; Signal Transduction ; Fatty Acids ; Fatty Acids ; Cpg Islands ; Diabetes Mellitus ; Blood Cells ; Cardiovascular Diseases ; Nuts ; Erythrocytes ; Lipids ; Diabetes Mellitus ; Olive Oil ; Intervention ; Methylation ; Lipids ; Metabolism ; Environmental Factors ; Olive Oil ; Environmental Factors ; Diet ; Health Risks ; Diabetes Mellitus ; Deoxyribonucleic Acid–DNA ; Deoxyribonucleic Acid–DNA
descriptionDNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group. Methylation was assessed at baseline and at five-year follow-up. Ingenuity pathway analysis showed routes with differentially methylated CpG sites (CpGs) related to intermediate metabolism, diabetes, inflammation, and signal transduction. Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism. Furthermore, cg01081346 was associated with PUFAs intake, showing a role for specific fatty acids on epigenetic modulation. Specific components of MedDiet, particularly nuts and EVOO, were able to induce methylation changes in several PWBCs genes. These changes may have potential benefits in health; especially those changes in genes related to intermediate metabolism, diabetes, inflammation and signal transduction, which may contribute to explain the role of MedDiet and fat quality on health outcomes.
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titleImpact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
descriptionDNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group. Methylation was assessed at baseline and at five-year follow-up. Ingenuity pathway analysis showed routes with differentially methylated CpG sites (CpGs) related to intermediate metabolism, diabetes, inflammation, and signal transduction. Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism. Furthermore, cg01081346 was associated with PUFAs intake, showing a role for specific fatty acids on epigenetic modulation. Specific components of MedDiet, particularly nuts and EVOO, were able to induce methylation changes in several PWBCs genes. These changes may have potential benefits in health; especially those changes in genes related to intermediate metabolism, diabetes, inflammation and signal transduction, which may contribute to explain the role of MedDiet and fat quality on health outcomes.
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titleImpact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
authorArpón, Ana ; Milagro, Fermín ; Razquin, Cristina ; Corella, Dolores ; Estruch, Ramón ; Fitó, Montserrat ; Marti, Amelia ; Martínez-Gonzalez, Miguel ; Ros, Emilio ; Salas-Salvadó, Jordi ; Martínez, J
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1Blood
2Diabetes
3Diet
4Fatty Acids
5Methylation
6Nuts
7Genes
8Metabolism
9Transduction
10Fats and Oils
11Leukocytes
12White Blood Cells
13Lipids
14Signal Transduction
15Cpg Islands
16Diabetes Mellitus
17Blood Cells
18Cardiovascular Diseases
19Erythrocytes
20Olive Oil
21Intervention
22Environmental Factors
23Health Risks
24Deoxyribonucleic Acid–DNA
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atitleImpact of Consuming Extra-Virgin Olive Oil or Nuts within a Mediterranean Diet on DNA Methylation in Peripheral White Blood Cells within the PREDIMED-Navarra Randomized Controlled Trial: A Role for Dietary Lipids
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abstractDNA methylation could be reversible and mouldable by environmental factors, such as dietary exposures. The objective was to analyse whether an intervention with two Mediterranean diets, one rich in extra-virgin olive oil (MedDiet + EVOO) and the other one in nuts (MedDiet + nuts), was influencing the methylation status of peripheral white blood cells (PWBCs) genes. A subset of 36 representative individuals were selected within the PREvención con DIeta MEDiterránea (PREDIMED-Navarra) trial, with three intervention groups in high cardiovascular risk volunteers: MedDiet + EVOO, MedDiet + nuts, and a low-fat control group. Methylation was assessed at baseline and at five-year follow-up. Ingenuity pathway analysis showed routes with differentially methylated CpG sites (CpGs) related to intermediate metabolism, diabetes, inflammation, and signal transduction. Two CpGs were specifically selected: cg01081346-CPT1B/CHKB-CPT1B and cg17071192-GNAS/GNASAS, being associated with intermediate metabolism. Furthermore, cg01081346 was associated with PUFAs intake, showing a role for specific fatty acids on epigenetic modulation. Specific components of MedDiet, particularly nuts and EVOO, were able to induce methylation changes in several PWBCs genes. These changes may have potential benefits in health; especially those changes in genes related to intermediate metabolism, diabetes, inflammation and signal transduction, which may contribute to explain the role of MedDiet and fat quality on health outcomes.
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