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Senescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis.

Chronic liver injury (CLI) is a complex pathological process typically characterized by progressive destruction and regeneration of liver parenchymal cells due to diverse risk factors such as alcohol abuse, drug toxicity, viral infection, and genetic metabolic disorders. When the damage to hepatocyt... Full description

Journal Title: Oncotarget February 2, 2018, Vol.9(9), pp.8772-8784
Main Author: Xiao, Mengchao
Other Authors: Chen, Wenjian , Wang, Chao , Wu, Yingfu , Zhu, Shiwei , Zeng, Chuyang , Cai, Yongchao , Liu, Changcheng , He, Zhiying
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.23622
Link: http://search.proquest.com/docview/2009568020/?pq-origsite=primo
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title: Senescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis.
format: Article
creator:
  • Xiao, Mengchao
  • Chen, Wenjian
  • Wang, Chao
  • Wu, Yingfu
  • Zhu, Shiwei
  • Zeng, Chuyang
  • Cai, Yongchao
  • Liu, Changcheng
  • He, Zhiying
subjects:
  • Apoptosis
  • Chronic Liver Injury
  • Necroptosis
  • Necrosis
  • Senescence
ispartof: Oncotarget, February 2, 2018, Vol.9(9), pp.8772-8784
description: Chronic liver injury (CLI) is a complex pathological process typically characterized by progressive destruction and regeneration of liver parenchymal cells due to diverse risk factors such as alcohol abuse, drug toxicity, viral infection, and genetic metabolic disorders. When the damage to hepatocytes is mild, the liver can regenerate itself and restore to the normal state; when the damage is irreparable, hepatocytes would undergo senescence or various forms of death including apoptosis, necrosis and necroptosis. These pathological changes not only promote the progression of the existing hepatopathies via various underlying mechanisms but are closely associated with hepatocarcinogenesis. In this review, we discuss the pathological changes that hepatocytes undergo during CLI, and their roles and mechanisms in the progression of hepatopathies and hepatocarcinogenesis. We also give a brief introduction about some animal models currently used for the research of CLI and progress in the research of CLI.
language: eng
source:
identifier: E-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.23622
fulltext: fulltext
issn:
  • 19492553
  • 1949-2553
url: Link


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titleSenescence and cell death in chronic liver injury: roles and mechanisms underlying hepatocarcinogenesis.
creatorXiao, Mengchao ; Chen, Wenjian ; Wang, Chao ; Wu, Yingfu ; Zhu, Shiwei ; Zeng, Chuyang ; Cai, Yongchao ; Liu, Changcheng ; He, Zhiying
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ispartofOncotarget, February 2, 2018, Vol.9(9), pp.8772-8784
identifierE-ISSN: 1949-2553 ; DOI: 10.18632/oncotarget.23622
subjectApoptosis ; Chronic Liver Injury ; Necroptosis ; Necrosis ; Senescence
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descriptionChronic liver injury (CLI) is a complex pathological process typically characterized by progressive destruction and regeneration of liver parenchymal cells due to diverse risk factors such as alcohol abuse, drug toxicity, viral infection, and genetic metabolic disorders. When the damage to hepatocytes is mild, the liver can regenerate itself and restore to the normal state; when the damage is irreparable, hepatocytes would undergo senescence or various forms of death including apoptosis, necrosis and necroptosis. These pathological changes not only promote the progression of the existing hepatopathies via various underlying mechanisms but are closely associated with hepatocarcinogenesis. In this review, we discuss the pathological changes that hepatocytes undergo during CLI, and their roles and mechanisms in the progression of hepatopathies and hepatocarcinogenesis. We also give a brief introduction about some animal models currently used for the research of CLI and progress in the research of CLI.
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