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Environment dominates over host genetics in shaping human gut microbiota.

Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrat... Full description

Journal Title: Nature March 8, 2018, Vol.555(7695), pp.210-215
Main Author: Rothschild, Daphna
Other Authors: Weissbrod, Omer , Barkan, Elad , Kurilshikov, Alexander , Korem, Tal , Zeevi, David , Costea, Paul I , Godneva, Anastasia , Kalka, Iris N , Bar, Noam , Shilo, Smadar , Lador, Dar , Vila, Arnau Vich , Zmora, Niv , Pevsner-Fischer, Meirav , Israeli, David , Kosower, Noa , Malka, Gal , Wolf, Bat Chen , Avnit-Sagi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-4687 ; DOI: 10.1038/nature25973
Link: http://search.proquest.com/docview/2009569352/?pq-origsite=primo
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title: Environment dominates over host genetics in shaping human gut microbiota.
format: Article
creator:
  • Rothschild, Daphna
  • Weissbrod, Omer
  • Barkan, Elad
  • Kurilshikov, Alexander
  • Korem, Tal
  • Zeevi, David
  • Costea, Paul I
  • Godneva, Anastasia
  • Kalka, Iris N
  • Bar, Noam
  • Shilo, Smadar
  • Lador, Dar
  • Vila, Arnau Vich
  • Zmora, Niv
  • Pevsner-Fischer, Meirav
  • Israeli, David
  • Kosower, Noa
  • Malka, Gal
  • Wolf, Bat Chen
  • Avnit-Sagi
subjects:
  • Adolescent–Statistics & Numerical Data
  • Adult–Genetics
  • Aged–Metabolism
  • Aged, 80 and Over–Genetics
  • Cohort Studies–Metabolism
  • Diet–Genetics
  • Environment–Analysis
  • Family Characteristics–Genetics
  • Female–Analysis
  • Gastrointestinal Microbiome–Genetics
  • Gene-Environment Interaction–Genetics
  • Glucose–Genetics
  • Healthy Volunteers–Genetics
  • Heredity–Genetics
  • Humans–Genetics
  • Israel–Genetics
  • Life Style–Genetics
  • Male–Genetics
  • Middle Aged
ispartof: Nature, March 8, 2018, Vol.555(7695), pp.210-215
description: Human gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.
language: eng
source:
identifier: E-ISSN: 1476-4687 ; DOI: 10.1038/nature25973
fulltext: fulltext
issn:
  • 14764687
  • 1476-4687
url: Link


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titleEnvironment dominates over host genetics in shaping human gut microbiota.
creatorRothschild, Daphna ; Weissbrod, Omer ; Barkan, Elad ; Kurilshikov, Alexander ; Korem, Tal ; Zeevi, David ; Costea, Paul I ; Godneva, Anastasia ; Kalka, Iris N ; Bar, Noam ; Shilo, Smadar ; Lador, Dar ; Vila, Arnau Vich ; Zmora, Niv ; Pevsner-Fischer, Meirav ; Israeli, David ; Kosower, Noa ; Malka, Gal ; Wolf, Bat Chen ; Avnit-Sagi
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identifierE-ISSN: 1476-4687 ; DOI: 10.1038/nature25973
subjectAdolescent–Statistics & Numerical Data ; Adult–Genetics ; Aged–Metabolism ; Aged, 80 and Over–Genetics ; Cohort Studies–Metabolism ; Diet–Genetics ; Environment–Analysis ; Family Characteristics–Genetics ; Female–Analysis ; Gastrointestinal Microbiome–Genetics ; Gene-Environment Interaction–Genetics ; Glucose–Genetics ; Healthy Volunteers–Genetics ; Heredity–Genetics ; Humans–Genetics ; Israel–Genetics ; Life Style–Genetics ; Male–Genetics ; Middle Aged
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descriptionHuman gut microbiome composition is shaped by multiple factors but the relative contribution of host genetics remains elusive. Here we examine genotype and microbiome data from 1,046 healthy individuals with several distinct ancestral origins who share a relatively common environment, and demonstrate that the gut microbiome is not significantly associated with genetic ancestry, and that host genetics have a minor role in determining microbiome composition. We show that, by contrast, there are significant similarities in the compositions of the microbiomes of genetically unrelated individuals who share a household, and that over 20% of the inter-person microbiome variability is associated with factors related to diet, drugs and anthropometric measurements. We further demonstrate that microbiome data significantly improve the prediction accuracy for many human traits, such as glucose and obesity measures, compared to models that use only host genetic and environmental data. These results suggest that microbiome alterations aimed at improving clinical outcomes may be carried out across diverse genetic backgrounds.
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titleEnvironment dominates over host genetics in shaping human gut microbiota.
authorRothschild, Daphna ; Weissbrod, Omer ; Barkan, Elad ; Kurilshikov, Alexander ; Korem, Tal ; Zeevi, David ; Costea, Paul I ; Godneva, Anastasia ; Kalka, Iris N ; Bar, Noam ; Shilo, Smadar ; Lador, Dar ; Vila, Arnau Vich ; Zmora, Niv ; Pevsner-Fischer, Meirav ; Israeli, David ; Kosower, Noa ; Malka, Gal ; Wolf, Bat Chen ; Avnit-Sagi
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