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Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome

Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P...] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P... balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of it... Full description

Journal Title: Proceedings of the National Academy of Sciences of the United States of America Jul 8, 2008, Vol.105(27), p.9415
Main Author: Voronov, Sergey
Other Authors: Frere, Samuel , Giovedi, Silvia , Pollina, Elizabeth , Borel, Christelle , Zhang, Hong , Schmidt, Cecilia , Akeson, Ellen , Wenk, Markus , Cimasoni, Laurent , Arancio, Ottavio , Davisson, Muriel , Antonarakis, Stylianos , Gardiner, Katheleen , Camilli, Pietro , Paolo, Gilbert
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00278424 ; E-ISSN: 10916490
Link: http://search.proquest.com/docview/201288573/?pq-origsite=primo
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title: Synaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
format: Article
creator:
  • Voronov, Sergey
  • Frere, Samuel
  • Giovedi, Silvia
  • Pollina, Elizabeth
  • Borel, Christelle
  • Zhang, Hong
  • Schmidt, Cecilia
  • Akeson, Ellen
  • Wenk, Markus
  • Cimasoni, Laurent
  • Arancio, Ottavio
  • Davisson, Muriel
  • Antonarakis, Stylianos
  • Gardiner, Katheleen
  • Camilli, Pietro
  • Paolo, Gilbert
subjects:
  • Down Syndrome
  • Gene Expression
  • Proteins
  • Rodents
  • Lipids
  • Cells
  • Metabolism
ispartof: Proceedings of the National Academy of Sciences of the United States of America, Jul 8, 2008, Vol.105(27), p.9415
description: Phosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P...] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P... balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its...
language: eng
source:
identifier: ISSN: 00278424 ; E-ISSN: 10916490
fulltext: fulltext
issn:
  • 00278424
  • 0027-8424
  • 10916490
  • 1091-6490
url: Link


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titleSynaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
creatorVoronov, Sergey ; Frere, Samuel ; Giovedi, Silvia ; Pollina, Elizabeth ; Borel, Christelle ; Zhang, Hong ; Schmidt, Cecilia ; Akeson, Ellen ; Wenk, Markus ; Cimasoni, Laurent ; Arancio, Ottavio ; Davisson, Muriel ; Antonarakis, Stylianos ; Gardiner, Katheleen ; Camilli, Pietro ; Paolo, Gilbert
ispartofProceedings of the National Academy of Sciences of the United States of America, Jul 8, 2008, Vol.105(27), p.9415
identifierISSN: 00278424 ; E-ISSN: 10916490
subjectDown Syndrome ; Gene Expression ; Proteins ; Rodents ; Lipids ; Cells ; Metabolism
descriptionPhosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P...] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P... balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its...
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titleSynaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
descriptionPhosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P...] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P... balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its...
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titleSynaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
authorVoronov, Sergey ; Frere, Samuel ; Giovedi, Silvia ; Pollina, Elizabeth ; Borel, Christelle ; Zhang, Hong ; Schmidt, Cecilia ; Akeson, Ellen ; Wenk, Markus ; Cimasoni, Laurent ; Arancio, Ottavio ; Davisson, Muriel ; Antonarakis, Stylianos ; Gardiner, Katheleen ; Camilli, Pietro ; Paolo, Gilbert
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atitleSynaptojanin 1-linked phosphoinositide dyshomeostasis and cognitive deficits in mouse models of Down's syndrome
jtitleProceedings of the National Academy of Sciences of the United States of America
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abstractPhosphatidylinositol-4,5-bisphosphate [PtdIns(4,5)P...] is a signaling phospholipid implicated in a wide variety of cellular functions. At synapses, where normal PtdIns(4,5)P... balance is required for proper neurotransmission, the phosphoinositide phosphatase synaptojanin 1 is a key regulator of its...
copWashington
pubNational Academy of Sciences
urlhttp://search.proquest.com/docview/201288573/
pages9415-9420
doi10.1073/pnas.0803756105
date2008-07-08