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MicroRNA-125a-5p Affects Adipocytes Proliferation, Differentiation and Fatty Acid Composition of Porcine Intramuscular Fat

Intramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipog... Full description

Journal Title: International Journal of Molecular Sciences Feb 2018, Vol.19(2), p.501
Main Author: Du, Jingjing
Other Authors: Xu, Yan , Zhang, Peiwen , Zhao, Xue , Gan, Mailin , Li, Qiang , Ma, Jideng , Tang, Guoqing , Jiang, Yanzhi , Wang, Jinyong , Li, Xuewei , Zhang, Shunhua , Zhu, Li
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 16616596 ; E-ISSN: 14220067 ; DOI: 10.3390/ijms19020501
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title: MicroRNA-125a-5p Affects Adipocytes Proliferation, Differentiation and Fatty Acid Composition of Porcine Intramuscular Fat
format: Article
creator:
  • Du, Jingjing
  • Xu, Yan
  • Zhang, Peiwen
  • Zhao, Xue
  • Gan, Mailin
  • Li, Qiang
  • Ma, Jideng
  • Tang, Guoqing
  • Jiang, Yanzhi
  • Wang, Jinyong
  • Li, Xuewei
  • Zhang, Shunhua
  • Zhu, Li
subjects:
  • Differentiation
  • Adipogenesis
  • Fatty Acids
  • Preadipocytes
  • Fatty Acids
  • Muscles
  • Meat
  • Adipocytes
  • Fatty Acid Composition
  • Fatty Acids
  • Polyunsaturated Fatty Acids
  • Micrornas
  • Inhibition
  • Target Recognition
  • Kruppel Protein
  • Meat
  • Chromosome 5
  • Adipocytes
  • Hogs
  • Ribonucleic Acid–RNA
ispartof: International Journal of Molecular Sciences, Feb 2018, Vol.19(2), p.501
description: Intramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an important regulator of adipogenesis. In the present study, we found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcine muscle tissues were negatively involved with IMF content. To investigate the potential function role of miR-125a-5p in IMF development, porcine intramuscular preadipocytes were collected and transfected with miR-125a-5p mimics, inhibitors, or a negative control (NC), respectively. The results showed that overexpression of miR-125a-5p promoted proliferation and inhibited differentiation of...
language: eng
source:
identifier: ISSN: 16616596 ; E-ISSN: 14220067 ; DOI: 10.3390/ijms19020501
fulltext: fulltext_linktorsrc
issn:
  • 16616596
  • 1661-6596
  • 14220067
  • 1422-0067
url: Link


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titleMicroRNA-125a-5p Affects Adipocytes Proliferation, Differentiation and Fatty Acid Composition of Porcine Intramuscular Fat
creatorDu, Jingjing ; Xu, Yan ; Zhang, Peiwen ; Zhao, Xue ; Gan, Mailin ; Li, Qiang ; Ma, Jideng ; Tang, Guoqing ; Jiang, Yanzhi ; Wang, Jinyong ; Li, Xuewei ; Zhang, Shunhua ; Zhu, Li
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subjectDifferentiation ; Adipogenesis ; Fatty Acids ; Preadipocytes ; Fatty Acids ; Muscles ; Meat ; Adipocytes ; Fatty Acid Composition ; Fatty Acids ; Polyunsaturated Fatty Acids ; Micrornas ; Inhibition ; Target Recognition ; Kruppel Protein ; Meat ; Chromosome 5 ; Adipocytes ; Hogs ; Ribonucleic Acid–RNA
descriptionIntramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an important regulator of adipogenesis. In the present study, we found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcine muscle tissues were negatively involved with IMF content. To investigate the potential function role of miR-125a-5p in IMF development, porcine intramuscular preadipocytes were collected and transfected with miR-125a-5p mimics, inhibitors, or a negative control (NC), respectively. The results showed that overexpression of miR-125a-5p promoted proliferation and inhibited differentiation of...
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descriptionIntramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an important regulator of adipogenesis. In the present study, we found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcine muscle tissues were negatively involved with IMF content. To investigate the potential function role of miR-125a-5p in IMF development, porcine intramuscular preadipocytes were collected and transfected with miR-125a-5p mimics, inhibitors, or a negative control (NC), respectively. The results showed that overexpression of miR-125a-5p promoted proliferation and inhibited differentiation of...
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abstractIntramuscular fat (IMF) content and composition are considered crucial indicators of porcine meat quality. However, the molecular mechanism of porcine IMF development is still mostly unclear. Recently, new evidence suggested that microRNA (miRNAs) play important roles in porcine intramuscular adipogenesis. Previously, microRNA-125a-5p (miR-125a-5p) was identified as an important regulator of adipogenesis. In the present study, we found that the expression of miR-125a-5p is dynamically regulated during porcine intramuscular preadipocytes differentiation and that its expression levels in different porcine muscle tissues were negatively involved with IMF content. To investigate the potential function role of miR-125a-5p in IMF development, porcine intramuscular preadipocytes were collected and transfected with miR-125a-5p mimics, inhibitors, or a negative control (NC), respectively. The results showed that overexpression of miR-125a-5p promoted proliferation and inhibited differentiation of...
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