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6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound

The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding antica... Full description

Journal Title: Bioscience Reports Feb 28, 2018, Vol.38(1), p.1
Main Author: Sha, Huan-Huan
Other Authors: Wang, Zhen , Dong, Shu-Chen , Hu, Tian-Mu , Liu, Si-Wen , Zhang, Jun-Ying , Wu, Yang , Ma, Rong , Wu, Jian-Zhong , Chen, Dan , Feng, Ji-Feng
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 0144-8463 ; E-ISSN: 1573-4935
Link: http://search.proquest.com/docview/2017393071/?pq-origsite=primo
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title: 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound
format: Article
creator:
  • Sha, Huan-Huan
  • Wang, Zhen
  • Dong, Shu-Chen
  • Hu, Tian-Mu
  • Liu, Si-Wen
  • Zhang, Jun-Ying
  • Wu, Yang
  • Ma, Rong
  • Wu, Jian-Zhong
  • Chen, Dan
  • Feng, Ji-Feng
subjects:
  • Cancer
  • Cytotoxicity
  • Catalytic Activity
  • Glutathione
  • Glutathione
  • Glutathione Transferase
  • Apoptosis
  • Inhibitors
  • Antitumor Activity
  • Anticancer Properties
  • Phagocytosis
  • Apoptosis
  • Tumor Cell Lines
  • Catalysis
  • Inhibition
  • Peptidomimetics
  • Extrusion
  • Hexanol
  • Therapeutic Applications
  • Autophagy
ispartof: Bioscience Reports, Feb 28, 2018, Vol.38(1), p.1
description: The 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in different tumor models. In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1. It triggers apoptosis in several tumor cell lines and this cytotoxic activity is observed at micro and submicromolar concentrations. Importantly, studies have shown that NBDHEX acts as an anticancer drug by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. Additionally, some researchers also have discovered that NBDHEX can act as late-phase autophagy inhibitor, which...
language: eng
source:
identifier: ISSN: 0144-8463 ; E-ISSN: 1573-4935
fulltext: fulltext
issn:
  • 01448463
  • 0144-8463
  • 15734935
  • 1573-4935
url: Link


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title6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound
creatorSha, Huan-Huan ; Wang, Zhen ; Dong, Shu-Chen ; Hu, Tian-Mu ; Liu, Si-Wen ; Zhang, Jun-Ying ; Wu, Yang ; Ma, Rong ; Wu, Jian-Zhong ; Chen, Dan ; Feng, Ji-Feng
ispartofBioscience Reports, Feb 28, 2018, Vol.38(1), p.1
identifierISSN: 0144-8463 ; E-ISSN: 1573-4935
subjectCancer ; Cytotoxicity ; Catalytic Activity ; Glutathione ; Glutathione ; Glutathione Transferase ; Apoptosis ; Inhibitors ; Antitumor Activity ; Anticancer Properties ; Phagocytosis ; Apoptosis ; Tumor Cell Lines ; Catalysis ; Inhibition ; Peptidomimetics ; Extrusion ; Hexanol ; Therapeutic Applications ; Autophagy
descriptionThe 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in different tumor models. In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1. It triggers apoptosis in several tumor cell lines and this cytotoxic activity is observed at micro and submicromolar concentrations. Importantly, studies have shown that NBDHEX acts as an anticancer drug by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. Additionally, some researchers also have discovered that NBDHEX can act as late-phase autophagy inhibitor, which...
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title6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound
descriptionThe 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in different tumor models. In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1. It triggers apoptosis in several tumor cell lines and this cytotoxic activity is observed at micro and submicromolar concentrations. Importantly, studies have shown that NBDHEX acts as an anticancer drug by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. Additionally, some researchers also have discovered that NBDHEX can act as late-phase autophagy inhibitor, which...
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title6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol: a promising new anticancer compound
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abstractThe 7-nitro-2,1,3-nitrobenzoxadiazole (NBD) derivatives are a series of compounds containing the NBD scaffold that are not glutathione (GSH) peptidomimetics, and result in a strong inhibition of glutathione S-transferases (GSTs). Growing evidences highlight their pivotal roles and outstanding anticancer activity in different tumor models. In particular, 6-(7-nitro-2,1,3-benzoxadiazol-4-ylthio) hexanol (NBDHEX) is extensively studied, which is a very efficient inhibitor of GSTP1-1. It triggers apoptosis in several tumor cell lines and this cytotoxic activity is observed at micro and submicromolar concentrations. Importantly, studies have shown that NBDHEX acts as an anticancer drug by inhibiting GSTs catalytic activity, avoiding inconvenience of the inhibitor extrusion from the cell by specific pumps and disrupting the interaction between the GSTP1-1 and key signaling effectors. Additionally, some researchers also have discovered that NBDHEX can act as late-phase autophagy inhibitor, which...
copNew York
pubSpringer Nature B.V.
urlhttp://search.proquest.com/docview/2017393071/
doi10.1042/BSR20171440
date2018-02-28