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Half-life of Glycated Tryptophan in the Plasma of Chickens

Tryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily in chickens than in mammals. Part of tryptoph... Full description

Journal Title: The Journal of Poultry Science 2018, Vol.55(2), pp.117-119
Main Author: Makino, Ryosuke
Other Authors: Kita, Kazumi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 13467395 ; DOI: 10.2141/jpsa.0170158
Link: http://search.proquest.com/docview/2034907391/?pq-origsite=primo
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title: Half-life of Glycated Tryptophan in the Plasma of Chickens
format: Article
creator:
  • Makino, Ryosuke
  • Kita, Kazumi
subjects:
  • Mass Spectrometry
  • Blood
  • Liquid Chromatography
  • Tryptophan
  • Amino Acids
  • Hyperglycemia
  • Liquid Chromatography
  • Mass Spectrometry
  • Nonlinear Analysis
  • Regression Analysis
  • High Temperature
  • Blood Circulation
  • Hyperglycemia
  • Blood Circulation
  • Body Weight
  • Carboxylic Acids
  • Poultry
  • Half Life
  • Glycosylation
  • Tryptophan
  • Body Weight
  • Body Weight
  • Radioactive Half-Life
  • Chickens
  • Mass Spectroscopy
  • Regression Analysis
  • High Temperature
  • Liquid Chromatography
  • Serotonin
  • Poultry
  • Chickens
  • Serotonin
  • Chicken
  • Glycation
  • Php-Thβc
  • Plasma Half-Life
  • Tryptophan
ispartof: The Journal of Poultry Science, 2018, Vol.55(2), pp.117-119
description: Tryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily in chickens than in mammals. Part of tryptophan is non-enzymatically converted to two types of glycated tryptophan, tryptophan-Amadori product and (1R, 3S)-1-(d-gluco-1, 2, 3, 4, 5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC). Although these compounds are detected in the plasma of chickens, information on the half-life of PHP-THβC in the blood circulation is limited. Therefore, the present study aimed to measure the half-life of plasma PHP-THβC in chickens. PHP-THβC (114 nmol/0.2 mL/70 g body weight) was intravenously administered to chickens via the wing vein, and blood samples were collected at 0, 15, 30, 60, 180, 360, 720, and 1440 min after administration. Plasma concentrations of PHP-THβC were measured by liquid chromatography-mass spectrometry. Plasma PHP-THβC reached to a peak concentration of 16.1 βM at 30 min after administration, and then decreased rapidly to return to the physiological level (0 min) at 360 min after administration. The half-life of plasma PHP-THβC was calculated by non-linear regression analysis, and it was found to be 107 min. This study was the first to measure plasma half-life of glycated tryptophan.
language: eng
source:
identifier: ISSN: 13467395 ; DOI: 10.2141/jpsa.0170158
fulltext: fulltext
issn:
  • 13467395
  • 1346-7395
url: Link


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titleHalf-life of Glycated Tryptophan in the Plasma of Chickens
creatorMakino, Ryosuke ; Kita, Kazumi
ispartofThe Journal of Poultry Science, 2018, Vol.55(2), pp.117-119
identifierISSN: 13467395 ; DOI: 10.2141/jpsa.0170158
subjectMass Spectrometry ; Blood ; Liquid Chromatography ; Tryptophan ; Amino Acids ; Hyperglycemia ; Liquid Chromatography ; Mass Spectrometry ; Nonlinear Analysis ; Regression Analysis ; High Temperature ; Blood Circulation ; Hyperglycemia ; Blood Circulation ; Body Weight ; Carboxylic Acids ; Poultry ; Half Life ; Glycosylation ; Tryptophan ; Body Weight ; Body Weight ; Radioactive Half-Life ; Chickens ; Mass Spectroscopy ; Regression Analysis ; High Temperature ; Liquid Chromatography ; Serotonin ; Poultry ; Chickens ; Serotonin ; Chicken ; Glycation ; Php-Thβc ; Plasma Half-Life ; Tryptophan
descriptionTryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily in chickens than in mammals. Part of tryptophan is non-enzymatically converted to two types of glycated tryptophan, tryptophan-Amadori product and (1R, 3S)-1-(d-gluco-1, 2, 3, 4, 5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC). Although these compounds are detected in the plasma of chickens, information on the half-life of PHP-THβC in the blood circulation is limited. Therefore, the present study aimed to measure the half-life of plasma PHP-THβC in chickens. PHP-THβC (114 nmol/0.2 mL/70 g body weight) was intravenously administered to chickens via the wing vein, and blood samples were collected at 0, 15, 30, 60, 180, 360, 720, and 1440 min after administration. Plasma concentrations of PHP-THβC were measured by liquid chromatography-mass spectrometry. Plasma PHP-THβC reached to a peak concentration of 16.1 βM at 30 min after administration, and then decreased rapidly to return to the physiological level (0 min) at 360 min after administration. The half-life of plasma PHP-THβC was calculated by non-linear regression analysis, and it was found to be 107 min. This study was the first to measure plasma half-life of glycated tryptophan.
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descriptionTryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily in chickens than in mammals. Part of tryptophan is non-enzymatically converted to two types of glycated tryptophan, tryptophan-Amadori product and (1R, 3S)-1-(d-gluco-1, 2, 3, 4, 5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC). Although these compounds are detected in the plasma of chickens, information on the half-life of PHP-THβC in the blood circulation is limited. Therefore, the present study aimed to measure the half-life of plasma PHP-THβC in chickens. PHP-THβC (114 nmol/0.2 mL/70 g body weight) was intravenously administered to chickens via the wing vein, and blood samples were collected at 0, 15, 30, 60, 180, 360, 720, and 1440 min after administration. Plasma concentrations of PHP-THβC were measured by liquid chromatography-mass spectrometry. Plasma PHP-THβC reached to a peak concentration of 16.1 βM at 30 min after administration, and then decreased rapidly to return to the physiological level (0 min) at 360 min after administration. The half-life of plasma PHP-THβC was calculated by non-linear regression analysis, and it was found to be 107 min. This study was the first to measure plasma half-life of glycated tryptophan.
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abstractTryptophan, an essential amino acid, is enzymatically metabolized to two compounds, kynurenine and serotonin, and 95% of tryptophan is metabolized to kynurenine. As chickens have hyperglycemia and high temperature, tryptophan glycation occurs more easily in chickens than in mammals. Part of tryptophan is non-enzymatically converted to two types of glycated tryptophan, tryptophan-Amadori product and (1R, 3S)-1-(d-gluco-1, 2, 3, 4, 5-pentahydroxypentyl)-1,2,3,4-tetrahydro-β-carboline-3-carboxylic acid (PHP-THβC). Although these compounds are detected in the plasma of chickens, information on the half-life of PHP-THβC in the blood circulation is limited. Therefore, the present study aimed to measure the half-life of plasma PHP-THβC in chickens. PHP-THβC (114 nmol/0.2 mL/70 g body weight) was intravenously administered to chickens via the wing vein, and blood samples were collected at 0, 15, 30, 60, 180, 360, 720, and 1440 min after administration. Plasma concentrations of PHP-THβC were measured by liquid chromatography-mass spectrometry. Plasma PHP-THβC reached to a peak concentration of 16.1 βM at 30 min after administration, and then decreased rapidly to return to the physiological level (0 min) at 360 min after administration. The half-life of plasma PHP-THβC was calculated by non-linear regression analysis, and it was found to be 107 min. This study was the first to measure plasma half-life of glycated tryptophan.
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pubJapan Science and Technology Agency
doi10.2141/jpsa.0170158
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date2018-04-01