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Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses.

Human memory T cells that cross-react with epitopes from unrelated viruses can potentially modulate immune responses to subsequent infections by a phenomenon termed heterologous immunity. However, it is unclear whether similarities in structure rather than sequence underpin heterologous T cell cross... Full description

Journal Title: Journal of immunology (Baltimore Md. : 1950), June 15, 2018, Vol.200(12), pp.3993-4003
Main Author: Rowntree, Louise C
Other Authors: Nguyen, Thi H O , Halim, Hanim , Purcell, Anthony W , Rossjohn, Jamie , Gras, Stephanie , Kotsimbos, Tom C , Mifsud, Nicole A
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1800010
Link: http://search.proquest.com/docview/2036200565/?pq-origsite=primo
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title: Inability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses.
format: Article
creator:
  • Rowntree, Louise C
  • Nguyen, Thi H O
  • Halim, Hanim
  • Purcell, Anthony W
  • Rossjohn, Jamie
  • Gras, Stephanie
  • Kotsimbos, Tom C
  • Mifsud, Nicole A
subjects:
  • Cell Line–Immunology
  • Cross Reactions–Immunology
  • Epitopes, T-Lymphocyte–Immunology
  • HLA Antigens–Immunology
  • Humans–Immunology
  • Immunity, Heterologous–Immunology
  • Immunodominant Epitopes–Immunology
  • Immunologic Memory–Immunology
  • T-Lymphocytes–Immunology
  • Viruses–Immunology
  • Abridged
  • Epitopes, T-Lymphocyte
  • HLA Antigens
  • Immunodominant Epitopes
ispartof: Journal of immunology (Baltimore, Md. : 1950), June 15, 2018, Vol.200(12), pp.3993-4003
description: Human memory T cells that cross-react with epitopes from unrelated viruses can potentially modulate immune responses to subsequent infections by a phenomenon termed heterologous immunity. However, it is unclear whether similarities in structure rather than sequence underpin heterologous T cell cross-reactivity. In this study, we aimed to explore the mechanism of heterologous immunity involving immunodominant epitopes derived from common viruses restricted to high-frequency HLA allotypes (HLA-A*02:01, -B*07:02, and -B*08:01). We examined EBV-specific memory T cells for their ability to cross-react with CMV or influenza A virus–derived epitopes. Following T cell immunoassays to determine phenotype and function, complemented with biophysical and structural investigations of peptide/HLA complexes, we did not detect cross-reactivity of EBV-specific memory T cells toward either CMV or influenza A virus epitopes presented by any of the selected HLA allomorphs. Thus, despite the ubiquitous nature...
language: eng
source:
identifier: E-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1800010
fulltext: fulltext
issn:
  • 15506606
  • 1550-6606
url: Link


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titleInability To Detect Cross-Reactive Memory T Cells Challenges the Frequency of Heterologous Immunity among Common Viruses.
creatorRowntree, Louise C ; Nguyen, Thi H O ; Halim, Hanim ; Purcell, Anthony W ; Rossjohn, Jamie ; Gras, Stephanie ; Kotsimbos, Tom C ; Mifsud, Nicole A
contributorRowntree, Louise C (correspondence author) ; Rowntree, Louise C (record owner)
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identifierE-ISSN: 1550-6606 ; DOI: 10.4049/jimmunol.1800010
subjectCell Line–Immunology ; Cross Reactions–Immunology ; Epitopes, T-Lymphocyte–Immunology ; HLA Antigens–Immunology ; Humans–Immunology ; Immunity, Heterologous–Immunology ; Immunodominant Epitopes–Immunology ; Immunologic Memory–Immunology ; T-Lymphocytes–Immunology ; Viruses–Immunology ; Abridged ; Epitopes, T-Lymphocyte ; HLA Antigens ; Immunodominant Epitopes
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descriptionHuman memory T cells that cross-react with epitopes from unrelated viruses can potentially modulate immune responses to subsequent infections by a phenomenon termed heterologous immunity. However, it is unclear whether similarities in structure rather than sequence underpin heterologous T cell cross-reactivity. In this study, we aimed to explore the mechanism of heterologous immunity involving immunodominant epitopes derived from common viruses restricted to high-frequency HLA allotypes (HLA-A*02:01, -B*07:02, and -B*08:01). We examined EBV-specific memory T cells for their ability to cross-react with CMV or influenza A virus–derived epitopes. Following T cell immunoassays to determine phenotype and function, complemented with biophysical and structural investigations of peptide/HLA complexes, we did not detect cross-reactivity of EBV-specific memory T cells toward either CMV or influenza A virus epitopes presented by any of the selected HLA allomorphs. Thus, despite the ubiquitous nature...
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