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Group A Streptococcus tissue invasion by CD44-mediated cell signalling

Streptococcus pyogenes (also known as group A Streptococcus, GAS), the agent of streptococcal sore throat and invasive soft-tissue infections, attaches to human pharyngeal or skin epithelial cells through specific recognition of its hyaluronic acid capsular polysaccharide by the hyaluronic-acid-bind... Full description

Journal Title: Nature Dec 6, 2001, Vol.414(6864), pp.648-52
Main Author: Cywes, Colette
Other Authors: Wessels, Michael
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/414648a
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recordid: proquest204479550
title: Group A Streptococcus tissue invasion by CD44-mediated cell signalling
format: Article
creator:
  • Cywes, Colette
  • Wessels, Michael
subjects:
  • Antigens, Cd44–Metabolism
  • Bacterial Adhesion–Metabolism
  • Bacterial Capsules–Metabolism
  • Cell Membrane–Microbiology
  • Cell Membrane–Metabolism
  • Cells, Cultured–Microbiology
  • Child–Metabolism
  • Cytoskeleton–Ultrastructure
  • Fasciitis, Necrotizing–Metabolism
  • Humans–Microbiology
  • Hyaluronic Acid–Microbiology
  • Hyaluronic Acid–Ultrastructure
  • Intercellular Junctions–Metabolism
  • Intercellular Junctions–Cytology
  • Keratinocytes–Microbiology
  • Keratinocytes–Pathogenicity
  • Microscopy, Confocal–Metabolism
  • Molecular Mimicry–Metabolism
  • Phosphorylation–Metabolism
  • Protein-Tyrosine Kinases
ispartof: Nature, Dec 6, 2001, Vol.414(6864), pp.648-52
description: Streptococcus pyogenes (also known as group A Streptococcus, GAS), the agent of streptococcal sore throat and invasive soft-tissue infections, attaches to human pharyngeal or skin epithelial cells through specific recognition of its hyaluronic acid capsular polysaccharide by the hyaluronic-acid-binding protein CD44. Because ligation of CD44 by hyaluronic acid can induce epithelial cell movement on extracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule might induce similar cellular responses.
language: eng
source:
identifier: ISSN: 00280836 ; E-ISSN: 14764687 ; DOI: 10.1038/414648a
fulltext: fulltext
issn:
  • 00280836
  • 0028-0836
  • 14764687
  • 1476-4687
url: Link


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titleGroup A Streptococcus tissue invasion by CD44-mediated cell signalling
creatorCywes, Colette ; Wessels, Michael
ispartofNature, Dec 6, 2001, Vol.414(6864), pp.648-52
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subjectAntigens, Cd44–Metabolism ; Bacterial Adhesion–Metabolism ; Bacterial Capsules–Metabolism ; Cell Membrane–Microbiology ; Cell Membrane–Metabolism ; Cells, Cultured–Microbiology ; Child–Metabolism ; Cytoskeleton–Ultrastructure ; Fasciitis, Necrotizing–Metabolism ; Humans–Microbiology ; Hyaluronic Acid–Microbiology ; Hyaluronic Acid–Ultrastructure ; Intercellular Junctions–Metabolism ; Intercellular Junctions–Cytology ; Keratinocytes–Microbiology ; Keratinocytes–Pathogenicity ; Microscopy, Confocal–Metabolism ; Molecular Mimicry–Metabolism ; Phosphorylation–Metabolism ; Protein-Tyrosine Kinases
descriptionStreptococcus pyogenes (also known as group A Streptococcus, GAS), the agent of streptococcal sore throat and invasive soft-tissue infections, attaches to human pharyngeal or skin epithelial cells through specific recognition of its hyaluronic acid capsular polysaccharide by the hyaluronic-acid-binding protein CD44. Because ligation of CD44 by hyaluronic acid can induce epithelial cell movement on extracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule might induce similar cellular responses.
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titleGroup A Streptococcus tissue invasion by CD44-mediated cell signalling
authorCywes, Colette ; Wessels, Michael
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1Bacterial Adhesion–Metabolism
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3Cell Membrane–Microbiology
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5Cells, Cultured–Microbiology
6Child–Metabolism
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abstractStreptococcus pyogenes (also known as group A Streptococcus, GAS), the agent of streptococcal sore throat and invasive soft-tissue infections, attaches to human pharyngeal or skin epithelial cells through specific recognition of its hyaluronic acid capsular polysaccharide by the hyaluronic-acid-binding protein CD44. Because ligation of CD44 by hyaluronic acid can induce epithelial cell movement on extracellular matrix, we investigated whether molecular mimicry by the GAS hyaluronic acid capsule might induce similar cellular responses.
copLondon
pubNature Publishing Group
doi10.1038/414648a
urlhttp://search.proquest.com/docview/204479550/
date2001-12-06