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Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.

Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, whereas the exact underlying molecular mechanisms of MSCs in treating CD... Full description

Journal Title: Cell death & disease June 7, 2018, Vol.9(6), p.691
Main Author: Feng, Yuan
Other Authors: Liao, Yan , Huang, Weijun , Lai, Xingqiang , Luo, Jing , Du, Cong , Lin, Junyi , Zhang, Zhongyuan , Qiu, Dongbo , Liu, Qiuli , Shen, Huiyong , Xiang, Andy Peng , Zhang, Qi
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 2041-4889 ; DOI: 10.1038/s41419-018-0734-3
Link: http://search.proquest.com/docview/2052805805/?pq-origsite=primo
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title: Mesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
format: Article
creator:
  • Feng, Yuan
  • Liao, Yan
  • Huang, Weijun
  • Lai, Xingqiang
  • Luo, Jing
  • Du, Cong
  • Lin, Junyi
  • Zhang, Zhongyuan
  • Qiu, Dongbo
  • Liu, Qiuli
  • Shen, Huiyong
  • Xiang, Andy Peng
  • Zhang, Qi
subjects:
  • Animals–Drug Effects
  • Apoptosis–Drug Effects
  • Bone Marrow Cells–Metabolism
  • Calcium-Binding Proteins–Pharmacology
  • Cell Differentiation–Therapeutic Use
  • Cell Proliferation–Drug Effects
  • Colitis–Drug Effects
  • Cytokines–Chemically Induced
  • Extracellular Matrix Proteins–Drug Therapy
  • Immunomodulation–Pathology
  • Inflammation Mediators–Biosynthesis
  • Lymphocyte Activation–Pharmacology
  • Mesenchymal Stem Cells–Therapeutic Use
  • Mice, Inbred C57bl–Drug Effects
  • Peritoneal Lavage–Metabolism
  • Protein Processing, Post-Translational–Immunology
  • T-Lymphocytes, Regulatory–Metabolism
  • Trinitrobenzenesulfonic Acid–Drug Effects
  • Vitamin K–Cytology
  • Vitamin K
ispartof: Cell death & disease, June 7, 2018, Vol.9(6), p.691
description: Crohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, whereas the exact underlying molecular mechanisms of MSCs in treating CD remain unclear. Furthermore, the heterogeneity of MSCs, as well as the in vivo microenvironments may influence the therapeutic efficacy. In our previous study, we found that a subpopulation of mouse MSCs with a high expression of matrix Gla protein (MGP), one of the members of vitamin K-dependent protein family, possessed better immunoregulatory properties. Therefore, in this study we investigate whether the abundant MSCs-derived MGP participate in the therapeutic mechanisms for MSCs treating CD. Obvious suppression of cell proliferation and cytokine production in T cells were observed in vitro through MSCs-derived MGP. Moreover, MGP alleviated the clinical and histopathological severity of colonic inflammation in mouse experimental colitis models to a remarkable degree. Our results indicate that MGP might be a novel important mediator of MSCs-mediated immunomodulation in treating CD.
language: eng
source:
identifier: E-ISSN: 2041-4889 ; DOI: 10.1038/s41419-018-0734-3
fulltext: fulltext
issn:
  • 20414889
  • 2041-4889
url: Link


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titleMesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
creatorFeng, Yuan ; Liao, Yan ; Huang, Weijun ; Lai, Xingqiang ; Luo, Jing ; Du, Cong ; Lin, Junyi ; Zhang, Zhongyuan ; Qiu, Dongbo ; Liu, Qiuli ; Shen, Huiyong ; Xiang, Andy Peng ; Zhang, Qi
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ispartofCell death & disease, June 7, 2018, Vol.9(6), p.691
identifierE-ISSN: 2041-4889 ; DOI: 10.1038/s41419-018-0734-3
subjectAnimals–Drug Effects ; Apoptosis–Drug Effects ; Bone Marrow Cells–Metabolism ; Calcium-Binding Proteins–Pharmacology ; Cell Differentiation–Therapeutic Use ; Cell Proliferation–Drug Effects ; Colitis–Drug Effects ; Cytokines–Chemically Induced ; Extracellular Matrix Proteins–Drug Therapy ; Immunomodulation–Pathology ; Inflammation Mediators–Biosynthesis ; Lymphocyte Activation–Pharmacology ; Mesenchymal Stem Cells–Therapeutic Use ; Mice, Inbred C57bl–Drug Effects ; Peritoneal Lavage–Metabolism ; Protein Processing, Post-Translational–Immunology ; T-Lymphocytes, Regulatory–Metabolism ; Trinitrobenzenesulfonic Acid–Drug Effects ; Vitamin K–Cytology ; Vitamin K
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descriptionCrohn’s disease (CD) is a chronic inflammatory bowel disease that is difficult to treat. However, previous preclinical and clinical studies have shown that mesenchymal stromal cells (MSCs) are a promising therapeutic approach, whereas the exact underlying molecular mechanisms of MSCs in treating CD remain unclear. Furthermore, the heterogeneity of MSCs, as well as the in vivo microenvironments may influence the therapeutic efficacy. In our previous study, we found that a subpopulation of mouse MSCs with a high expression of matrix Gla protein (MGP), one of the members of vitamin K-dependent protein family, possessed better immunoregulatory properties. Therefore, in this study we investigate whether the abundant MSCs-derived MGP participate in the therapeutic mechanisms for MSCs treating CD. Obvious suppression of cell proliferation and cytokine production in T cells were observed in vitro through MSCs-derived MGP. Moreover, MGP alleviated the clinical and histopathological severity of colonic inflammation in mouse experimental colitis models to a remarkable degree. Our results indicate that MGP might be a novel important mediator of MSCs-mediated immunomodulation in treating CD.
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titleMesenchymal stromal cells-derived matrix Gla protein contribute to the alleviation of experimental colitis.
authorFeng, Yuan ; Liao, Yan ; Huang, Weijun ; Lai, Xingqiang ; Luo, Jing ; Du, Cong ; Lin, Junyi ; Zhang, Zhongyuan ; Qiu, Dongbo ; Liu, Qiuli ; Shen, Huiyong ; Xiang, Andy Peng ; Zhang, Qi
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