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New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity

Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics usi... Full description

Journal Title: Polymers 2018, Vol.10(5), p.476
Main Author: Ran, Jingyu
Other Authors: Wang, Cong , Zhang, Jinjuan , Wang, Wei , Xiao, Lihua , Jia, Shaoyi , Wang, Ze , Wu, Weidang , Xiao, Jun , Wu, Xinyu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: DOI: Polymers 2018, 10(5), 476; 10.3390/polym10050476
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recordid: proquest2056389365
title: New Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity
format: Article
creator:
  • Ran, Jingyu
  • Wang, Cong
  • Zhang, Jinjuan
  • Wang, Wei
  • Xiao, Lihua
  • Jia, Shaoyi
  • Wang, Ze
  • Wu, Weidang
  • Xiao, Jun
  • Wu, Xinyu
subjects:
  • Transmission Electron Microscopy
  • Nanocrystals
  • Drug Carriers
  • Nanocrystals
  • Containers
  • Chemotherapy
  • Biocompatibility
  • Zinc Compounds
  • Dopamine
  • Cancer
  • Anticancer Properties
ispartof: Polymers, 2018, Vol.10(5), p.476
description: Despite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.
language: eng
source:
identifier: DOI: Polymers 2018, 10(5), 476; 10.3390/polym10050476
fulltext: fulltext_linktorsrc
url: Link


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titleNew Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity
creatorRan, Jingyu ; Wang, Cong ; Zhang, Jinjuan ; Wang, Wei ; Xiao, Lihua ; Jia, Shaoyi ; Wang, Ze ; Wu, Weidang ; Xiao, Jun ; Wu, Xinyu
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identifierDOI: Polymers 2018, 10(5), 476; 10.3390/polym10050476
subjectTransmission Electron Microscopy ; Nanocrystals ; Drug Carriers ; Nanocrystals ; Containers ; Chemotherapy ; Biocompatibility ; Zinc Compounds ; Dopamine ; Cancer ; Anticancer Properties
descriptionDespite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.
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titleNew Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity
descriptionDespite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.
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titleNew Insight into Polydopamine@ZIF-8 Nanohybrids: A Zinc-Releasing Container for Potential Anticancer Activity
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abstractDespite the initial evidence on the role of zinc and zinc transporters in cancer prevention, little attention has been paid to the zinc-derived compounds. In the present work, we reported a strategy to prepare a kind of zinc-releasing container with enhanced biocompatibility and release dynamics using ZIF-8 nanocrystals as the sacrificial templates. Transmission electron microscopy (TEM) analysis demonstrated that the ZIF-8 nanocrystals were gradually etched out in the aqueous media within 48 h, resulting in hollow nanocapsules. Notably, we found the self-polymerization of dopamine can form nanoshells around the ZIF-8 nanocrystals, which served as a type of functional membranes during the release of zinc. More interestingly, PDA@ZIF-8-based nanohybrids expressed stronger inhibition to the cancer cell growth, which implied that the nanohybrids could be a drug carrier for chemotherapy. This study broadens the biomedical application of ZIF-8 and also provides a versatile strategy toward the development of multifunctional delivery system.
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