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Using Genome Wide Estimates of Heritability to Examine the Relevance of Gene-Environment Interplay

We use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows es... Full description

Journal Title: BioRxiv Jan 26, 2016
Main Author: Domingue, Benjamin
Other Authors: Boardman, Jason
Format: Electronic Article Electronic Article
Language: English
Subjects:
Quelle: © ProQuest LLC All rights reserved
ID: DOI: 10.1101/037861
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recordid: proquest2070762655
title: Using Genome Wide Estimates of Heritability to Examine the Relevance of Gene-Environment Interplay
format: Article
creator:
  • Domingue, Benjamin
  • Boardman, Jason
subjects:
  • Genomes
  • Estimates
  • Single-Nucleotide Polymorphism
  • Heritability
  • Genotypes
  • Body Mass Index
  • Genomes
ispartof: BioRxiv, Jan 26, 2016
description: We use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows essentially no decline when SNPs implicated by a gene-environment interaction in a second genome-wide analysis are removed. This second result is highlighted by our additional finding that the SNPs which explain heritability amongst a subsample defined by higher educational attainment explain no heritability of the heritability in the lower education group, and vice-versa. Finally, we do find consistent heritability estimates when we compare family-based estimates versus those based on measured genotype.
language: eng
source: © ProQuest LLC All rights reserved
identifier: DOI: 10.1101/037861
fulltext: fulltext_linktorsrc
url: Link


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titleUsing Genome Wide Estimates of Heritability to Examine the Relevance of Gene-Environment Interplay
creatorDomingue, Benjamin ; Boardman, Jason
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identifierDOI: 10.1101/037861
subjectGenomes ; Estimates ; Single-Nucleotide Polymorphism ; Heritability ; Genotypes ; Body Mass Index ; Genomes
descriptionWe use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows essentially no decline when SNPs implicated by a gene-environment interaction in a second genome-wide analysis are removed. This second result is highlighted by our additional finding that the SNPs which explain heritability amongst a subsample defined by higher educational attainment explain no heritability of the heritability in the lower education group, and vice-versa. Finally, we do find consistent heritability estimates when we compare family-based estimates versus those based on measured genotype.
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abstractWe use genome-wide data from the third generation respondents of the Framingham Heart Study to estimate heritability in body mass index using different quantities of the measured genotype. Heritability decreases rapidly when SNPs implicated by a genome-wide association study are removed but shows essentially no decline when SNPs implicated by a gene-environment interaction in a second genome-wide analysis are removed. This second result is highlighted by our additional finding that the SNPs which explain heritability amongst a subsample defined by higher educational attainment explain no heritability of the heritability in the lower education group, and vice-versa. Finally, we do find consistent heritability estimates when we compare family-based estimates versus those based on measured genotype.
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