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Peptide nucleic acid mediated inhibition of the bacterial signal recognition particle

We have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating... Full description

Journal Title: Chemical Communications : Chem Comm 2018, Vol.54(59), pp.8257-8260
Main Author: Ghosh, Sudipta
Other Authors: Saini, Snehlata , Saraogi, Ishu
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1359-7345 ; DOI: 10.1039/c8cc04715d
Link: http://search.proquest.com/docview/2071940667/?pq-origsite=primo
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recordid: proquest2071940667
title: Peptide nucleic acid mediated inhibition of the bacterial signal recognition particle
format: Article
creator:
  • Ghosh, Sudipta
  • Saini, Snehlata
  • Saraogi, Ishu
subjects:
  • Inhibition
  • Ribonucleic Acids
  • Recognition
  • Molecular Chains
  • Bacteria
ispartof: Chemical Communications : Chem Comm, 2018, Vol.54(59), pp.8257-8260
description: We have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.
language: eng
source:
identifier: ISSN: 1359-7345 ; DOI: 10.1039/c8cc04715d
fulltext: fulltext
issn:
  • 13597345
  • 1359-7345
url: Link


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identifierISSN: 1359-7345 ; DOI: 10.1039/c8cc04715d
subjectInhibition ; Ribonucleic Acids ; Recognition ; Molecular Chains ; Bacteria
descriptionWe have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.
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abstractWe have identified the bacterial signal recognition particle (SRP) as a novel antibacterial target. As a proof of principle, we used an antisense peptide nucleic acid to target a key SRP RNA. The PNA molecules showed efficient inhibition of SRP function and bacterial cell growth, thereby validating our hypothesis.
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