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Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia

Background Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a well-characterized vaccine candidate in Plasmodium vivax and Plasmodium falcip... Full description

Journal Title: Malaria Journal 2018, Vol.17
Main Author: Lau, Yee
Other Authors: Fu-Shi, Quan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 14752875 ; DOI: 10.1186/s12936-018-2423-1
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title: Diversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia
format: Article
creator:
  • Lau, Yee
  • Fu-Shi, Quan
subjects:
  • Malaysia
  • Borneo
  • Plasmodium Knowlesi
  • Plasmodium Falciparum
  • Plasmodium Vivax
  • Plasmodium Coatneyi
  • Infections
  • Population
  • Malaria
  • Vaccines
  • Natural Selection
  • Proteins
  • Phylogenetics
  • Hypothesis Testing
  • Bioinformatics
  • Parasites
  • Studies
  • Acid Phosphatase (Tartrate-Resistant)
  • Adhesives
  • Antigens
ispartof: Malaria Journal, 2018, Vol.17
description: Background Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a well-characterized vaccine candidate in Plasmodium vivax and Plasmodium falciparum, however, no study has been done in the orthologous gene of P. knowlesi. This study investigates nucleotide diversity, haplotypes, natural selection and population differentiation of full-length pktrap genes in clinical samples from Malaysia. Methods Forty full-length pktrap sequences from clinical isolates of Malaysia along with the reference H-strain were downloaded from published databases. Genetic diversity, polymorphism, haplotype and natural selection were determined using DnaSP 5.10 software. McDonald–Kreitman test was conducted using P. vivax and Plasmodium coatneyi as ortholog sequence in DnaSP 5.10 software. Population genetic differentiation index (FST) of parasite populations...
language: eng
source:
identifier: E-ISSN: 14752875 ; DOI: 10.1186/s12936-018-2423-1
fulltext: fulltext_linktorsrc
issn:
  • 14752875
  • 1475-2875
url: Link


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titleDiversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia
creatorLau, Yee ; Fu-Shi, Quan
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identifierE-ISSN: 14752875 ; DOI: 10.1186/s12936-018-2423-1
subjectMalaysia ; Borneo ; Plasmodium Knowlesi ; Plasmodium Falciparum ; Plasmodium Vivax ; Plasmodium Coatneyi ; Infections ; Population ; Malaria ; Vaccines ; Natural Selection ; Proteins ; Phylogenetics ; Hypothesis Testing ; Bioinformatics ; Parasites ; Studies ; Acid Phosphatase (Tartrate-Resistant) ; Adhesives ; Antigens
descriptionBackground Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a well-characterized vaccine candidate in Plasmodium vivax and Plasmodium falciparum, however, no study has been done in the orthologous gene of P. knowlesi. This study investigates nucleotide diversity, haplotypes, natural selection and population differentiation of full-length pktrap genes in clinical samples from Malaysia. Methods Forty full-length pktrap sequences from clinical isolates of Malaysia along with the reference H-strain were downloaded from published databases. Genetic diversity, polymorphism, haplotype and natural selection were determined using DnaSP 5.10 software. McDonald–Kreitman test was conducted using P. vivax and Plasmodium coatneyi as ortholog sequence in DnaSP 5.10 software. Population genetic differentiation index (FST) of parasite populations...
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descriptionBackground Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a well-characterized vaccine candidate in Plasmodium vivax and Plasmodium falciparum, however, no study has been done in the orthologous gene of P. knowlesi. This study investigates nucleotide diversity, haplotypes, natural selection and population differentiation of full-length pktrap genes in clinical samples from Malaysia. Methods Forty full-length pktrap sequences from clinical isolates of Malaysia along with the reference H-strain were downloaded from published databases. Genetic diversity, polymorphism, haplotype and natural selection were determined using DnaSP 5.10 software. McDonald–Kreitman test was conducted using P. vivax and Plasmodium coatneyi as ortholog sequence in DnaSP 5.10 software. Population genetic differentiation index (FST) of parasite populations...
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titleDiversity and natural selection on the thrombospondin-related adhesive protein (TRAP) gene of Plasmodium knowlesi in Malaysia
authorLau, Yee ; Fu-Shi, Quan
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abstractBackground Plasmodium knowlesi a parasite of the macaques is currently the most common cause of human malaria in Malaysia. The thrombospondin-related adhesive protein (TRAP) gene is pre-erythrocytic stage antigen. It is a well-characterized vaccine candidate in Plasmodium vivax and Plasmodium falciparum, however, no study has been done in the orthologous gene of P. knowlesi. This study investigates nucleotide diversity, haplotypes, natural selection and population differentiation of full-length pktrap genes in clinical samples from Malaysia. Methods Forty full-length pktrap sequences from clinical isolates of Malaysia along with the reference H-strain were downloaded from published databases. Genetic diversity, polymorphism, haplotype and natural selection were determined using DnaSP 5.10 software. McDonald–Kreitman test was conducted using P. vivax and Plasmodium coatneyi as ortholog sequence in DnaSP 5.10 software. Population genetic differentiation index (FST) of parasite populations...
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