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miR-590-5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression

The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR-590-5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription-quantitative polymerase chain reaction to... Full description

Journal Title: Oncology Reports 2018, Vol.40(4), pp.2056-2066
Main Author: Mou, Kuanhou
Other Authors: Ding, Meiling , Han, Dan , Zhou, Yan , Mu, Xin , Liu, Wenli , Wang, Lijuan
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 1021335X ; E-ISSN: 17912431 ; DOI: 10.3892/or.2018.6633
Link: http://search.proquest.com/docview/2096268360/?pq-origsite=primo
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title: miR-590-5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression
format: Article
creator:
  • Mou, Kuanhou
  • Ding, Meiling
  • Han, Dan
  • Zhou, Yan
  • Mu, Xin
  • Liu, Wenli
  • Wang, Lijuan
subjects:
  • United States–Us
  • Germany
  • China
  • Medical Prognosis
  • Skin Cancer
  • Phase Transitions
  • Micrornas
  • Polymerase Chain Reaction
  • Melanoma
  • Apoptosis
  • Cell Growth
  • Cell Cycle
  • Hyclone
  • Chinese Academy of Sciences
  • Ge Healthcare
  • Malignant Melanoma
  • Microrna-590-5p
  • Yes-Associated Protein 1
  • Proliferation
ispartof: Oncology Reports, 2018, Vol.40(4), pp.2056-2066
description: The microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR-590-5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription-quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor miRNAs. miR-590-5p was demonstrated to inhibit the cell proliferation and tumor growth of MM cells in vitro and in vivo by performing Cell Counting Kit-8 and tumour xenograft assays, respectively. In addition, flowcytometry assays indicated that miR-590-5p induced cell apoptosis and cell cycle arrest at the G1 stage in MM cells. Finally, luciferase assays and western blot analysis results confirmed that the transcriptional regulator Yes-associated protein 1 (YAP1) is upregulated and inversely associated with miR-590-5p expression in MM cells, and is the direct target and functional mediator of miR-590-5p in MM. Altogether these results reveal...
language: eng
source:
identifier: ISSN: 1021335X ; E-ISSN: 17912431 ; DOI: 10.3892/or.2018.6633
fulltext: fulltext
issn:
  • 1021335X
  • 1021-335X
  • 17912431
  • 1791-2431
url: Link


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titlemiR-590-5p inhibits tumor growth in malignant melanoma by suppressing YAP1 expression
creatorMou, Kuanhou ; Ding, Meiling ; Han, Dan ; Zhou, Yan ; Mu, Xin ; Liu, Wenli ; Wang, Lijuan
ispartofOncology Reports, 2018, Vol.40(4), pp.2056-2066
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subjectUnited States–Us ; Germany ; China ; Medical Prognosis ; Skin Cancer ; Phase Transitions ; Micrornas ; Polymerase Chain Reaction ; Melanoma ; Apoptosis ; Cell Growth ; Cell Cycle ; Hyclone ; Chinese Academy of Sciences ; Ge Healthcare ; Malignant Melanoma ; Microrna-590-5p ; Yes-Associated Protein 1 ; Proliferation
descriptionThe microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR-590-5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription-quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor miRNAs. miR-590-5p was demonstrated to inhibit the cell proliferation and tumor growth of MM cells in vitro and in vivo by performing Cell Counting Kit-8 and tumour xenograft assays, respectively. In addition, flowcytometry assays indicated that miR-590-5p induced cell apoptosis and cell cycle arrest at the G1 stage in MM cells. Finally, luciferase assays and western blot analysis results confirmed that the transcriptional regulator Yes-associated protein 1 (YAP1) is upregulated and inversely associated with miR-590-5p expression in MM cells, and is the direct target and functional mediator of miR-590-5p in MM. Altogether these results reveal...
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descriptionThe microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR-590-5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription-quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor miRNAs. miR-590-5p was demonstrated to inhibit the cell proliferation and tumor growth of MM cells in vitro and in vivo by performing Cell Counting Kit-8 and tumour xenograft assays, respectively. In addition, flowcytometry assays indicated that miR-590-5p induced cell apoptosis and cell cycle arrest at the G1 stage in MM cells. Finally, luciferase assays and western blot analysis results confirmed that the transcriptional regulator Yes-associated protein 1 (YAP1) is upregulated and inversely associated with miR-590-5p expression in MM cells, and is the direct target and functional mediator of miR-590-5p in MM. Altogether these results reveal...
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abstractThe microRNAs (miRNAs/miRs) involved in the carcinogenesis and progression of malignant melanoma (MM) remain unclear. In the present study, miR-590-5p was identified to be upregulated in MM cells compared with human melanocytes using a reverse transcription-quantitative polymerase chain reaction to screen established oncogenic and tumor suppressor miRNAs. miR-590-5p was demonstrated to inhibit the cell proliferation and tumor growth of MM cells in vitro and in vivo by performing Cell Counting Kit-8 and tumour xenograft assays, respectively. In addition, flowcytometry assays indicated that miR-590-5p induced cell apoptosis and cell cycle arrest at the G1 stage in MM cells. Finally, luciferase assays and western blot analysis results confirmed that the transcriptional regulator Yes-associated protein 1 (YAP1) is upregulated and inversely associated with miR-590-5p expression in MM cells, and is the direct target and functional mediator of miR-590-5p in MM. Altogether these results reveal...
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pubSpandidos Publications UK Ltd.
doi10.3892/or.2018.6633
urlhttp://search.proquest.com/docview/2096268360/
pages2056-2066
date2018-01-01