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Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis

The expression of PD-L1 in tumor cells is one of the main causes of tumor immune escape. However, the exact mechanism for regulating PD-L1 expression in gastric cancer (GC) cells remains unclear. Our previous studies have shown that mesenchymal stem cells (MSCs) exert broad immunosuppressive potenti... Full description

Journal Title: Cell Death and Disease Sep 2018, Vol.9, pp.1-11
Main Author: Sun, Li
Other Authors: Wang, Qianqian , Chen, Bin , Zhao, Yuanyuan , Shen, Bo , Wang, Hua , Xu, Jing , Zhu, Miaolin , Zhao, Xiangdong , Xu, Changgen , Chen, Zhihong , Wang, Mei , Xu, Wenrong , Zhu, Wei
Format: Electronic Article Electronic Article
Language: English
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ID: E-ISSN: 20414889 ; DOI: 10.1038/s41419-018-0988-9
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recordid: proquest2102377422
title: Gastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
format: Article
creator:
  • Sun, Li
  • Wang, Qianqian
  • Chen, Bin
  • Zhao, Yuanyuan
  • Shen, Bo
  • Wang, Hua
  • Xu, Jing
  • Zhu, Miaolin
  • Zhao, Xiangdong
  • Xu, Changgen
  • Chen, Zhihong
  • Wang, Mei
  • Xu, Wenrong
  • Zhu, Wei
subjects:
  • Cytotoxicity
  • PD-L1 Protein
  • Tumor Cells
  • Mesenchyme
  • Immunotherapy
  • Tor Protein
  • Lymphocytes T
  • C-Myc Protein
  • Stat3 Protein
  • Stomach Cancer
  • Myc Protein
  • Immunosuppressive Agents
  • Gastric Cancer
  • Immune System
  • Stem Cells
  • Interleukin 8
  • Stem Cells
  • Cd8 Antigen
ispartof: Cell Death and Disease, Sep 2018, Vol.9, pp.1-11
description: The expression of PD-L1 in tumor cells is one of the main causes of tumor immune escape. However, the exact mechanism for regulating PD-L1 expression in gastric cancer (GC) cells remains unclear. Our previous studies have shown that mesenchymal stem cells (MSCs) exert broad immunosuppressive potential,...
language: eng
source:
identifier: E-ISSN: 20414889 ; DOI: 10.1038/s41419-018-0988-9
fulltext: fulltext_linktorsrc
issn:
  • 20414889
  • 2041-4889
url: Link


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titleGastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
creatorSun, Li ; Wang, Qianqian ; Chen, Bin ; Zhao, Yuanyuan ; Shen, Bo ; Wang, Hua ; Xu, Jing ; Zhu, Miaolin ; Zhao, Xiangdong ; Xu, Changgen ; Chen, Zhihong ; Wang, Mei ; Xu, Wenrong ; Zhu, Wei
ispartofCell Death and Disease, Sep 2018, Vol.9, pp.1-11
identifierE-ISSN: 20414889 ; DOI: 10.1038/s41419-018-0988-9
subjectCytotoxicity ; PD-L1 Protein ; Tumor Cells ; Mesenchyme ; Immunotherapy ; Tor Protein ; Lymphocytes T ; C-Myc Protein ; Stat3 Protein ; Stomach Cancer ; Myc Protein ; Immunosuppressive Agents ; Gastric Cancer ; Immune System ; Stem Cells ; Interleukin 8 ; Stem Cells ; Cd8 Antigen
descriptionThe expression of PD-L1 in tumor cells is one of the main causes of tumor immune escape. However, the exact mechanism for regulating PD-L1 expression in gastric cancer (GC) cells remains unclear. Our previous studies have shown that mesenchymal stem cells (MSCs) exert broad immunosuppressive potential,...
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titleGastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
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titleGastric cancer mesenchymal stem cells derived IL-8 induces PD-L1 expression in gastric cancer cells via STAT3/mTOR-c-Myc signal axis
authorSun, Li ; Wang, Qianqian ; Chen, Bin ; Zhao, Yuanyuan ; Shen, Bo ; Wang, Hua ; Xu, Jing ; Zhu, Miaolin ; Zhao, Xiangdong ; Xu, Changgen ; Chen, Zhihong ; Wang, Mei ; Xu, Wenrong ; Zhu, Wei
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abstractThe expression of PD-L1 in tumor cells is one of the main causes of tumor immune escape. However, the exact mechanism for regulating PD-L1 expression in gastric cancer (GC) cells remains unclear. Our previous studies have shown that mesenchymal stem cells (MSCs) exert broad immunosuppressive potential,...
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