schliessen

Filtern

 

Bibliotheken

MicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.

BACKGROUNDGenetically selected modern broiler chickens have acquired outstanding production efficiency through rapid growth and improved feed efficiency compared to unselected chicken breeds. Recently, we analyzed the transcriptome of breast muscle tissues obtained from modern pedigree male (PeM) br... Full description

Journal Title: BMC genomics September 17, 2018, Vol.19(1), p.683
Main Author: Khatri, Bhuwan
Other Authors: Seo, Dongwon , Shouse, Stephanie , Pan, Jeong Hoon , Hudson, Nicholas J , Kim, Jae Kyeom , Bottje, Walter , Kong, Byungwhi C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1471-2164 ; DOI: 1471-2164 ; DOI: 10.1186/s12864-018-5061-7
Link: http://search.proquest.com/docview/2109333006/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest2109333006
title: MicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.
format: Article
creator:
  • Khatri, Bhuwan
  • Seo, Dongwon
  • Shouse, Stephanie
  • Pan, Jeong Hoon
  • Hudson, Nicholas J
  • Kim, Jae Kyeom
  • Bottje, Walter
  • Kong, Byungwhi C
subjects:
  • Animals–Growth & Development
  • Breast–Genetics
  • Breeding–Growth & Development
  • Chickens–Classification
  • Cluster Analysis–Genetics
  • Computational Biology–Metabolism
  • Gene Expression Regulation–Genetics
  • Male–Genetics
  • Metabolic Networks and Pathways–Genetics
  • Micrornas–Genetics
  • Muscle Development–Genetics
  • RNA, Messenger–Genetics
  • Transcriptome–Genetics
  • Micrornas
  • RNA, Messenger
  • Barred Plymouth Rock
  • Differential Expression
  • Pedigree Male Broiler
  • Production Efficiency
  • Mirna
ispartof: BMC genomics, September 17, 2018, Vol.19(1), p.683
description: BACKGROUNDGenetically selected modern broiler chickens have acquired outstanding production efficiency through rapid growth and improved feed efficiency compared to unselected chicken breeds. Recently, we analyzed the transcriptome of breast muscle tissues obtained from modern pedigree male (PeM) broilers (rapid growth and higher efficiency) and foundational Barred Plymouth Rock (BPR) chickens (slow growth and poorer efficiency). This study was designed to investigate microRNAs that play role in rapid growth of the breast muscles in modern broiler chickens. RESULTSIn this study, differential abundance of microRNA (miRNA) was analyzed in breast muscle of PeM and BPR chickens and the results were integrated with differentially expressed (DE) mRNA in the same tissues. A total of 994 miRNA were identified in PeM and BPR chicken lines from the initial analysis of small RNA sequencing data. After filtering and statistical analyses, the results showed miR-2131-5p, miR-221-5p, miR-126-3p, miR-146b-5p, miR-10a-5p, let-7b, miR-125b-5p, and miR-146c-5p up-regulated whereas miR-206 down-regulated in PeM compared to BPR breast muscle. Based on inhibitory regulations of miRNAs on the mRNA abundance, our computational analysis using miRDB, an online software, predicated that 118 down-regulated mRNAs may be targeted by the up-regulated miRNAs, while 35 up-regulated mRNAs appear to be due to a down-regulated miRNA (i.e., miR-206). Functional network analyses of target genes of DE miRNAs showed their involvement in calcium signaling, axonal guidance signaling, and NRF2-mediated oxidative stress response pathways suggesting their involvement in breast muscle growth in chickens. CONCLUSIONFrom the integrated analyses of differentially expressed miRNA-mRNA data, we were able to identify breast muscle specific miRNAs and their target genes whose concerted actions can contribute to rapid growth and higher feed efficiency in modern broiler chickens. This study provides foundation data for elucidating molecular mechanisms that govern muscle growth in chickens.
language: eng
source:
identifier: E-ISSN: 1471-2164 ; DOI: 1471-2164 ; DOI: 10.1186/s12864-018-5061-7
fulltext: fulltext
issn:
  • 14712164
  • 1471-2164
url: Link


@attributes
ID1360958454
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid2109333006
sourceidproquest
recordidTN_proquest2109333006
sourcesystemOther
pqid2109333006
galeid557726199
display
typearticle
titleMicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.
creatorKhatri, Bhuwan ; Seo, Dongwon ; Shouse, Stephanie ; Pan, Jeong Hoon ; Hudson, Nicholas J ; Kim, Jae Kyeom ; Bottje, Walter ; Kong, Byungwhi C
contributorKhatri, Bhuwan (correspondence author) ; Khatri, Bhuwan (record owner)
ispartofBMC genomics, September 17, 2018, Vol.19(1), p.683
identifier
subjectAnimals–Growth & Development ; Breast–Genetics ; Breeding–Growth & Development ; Chickens–Classification ; Cluster Analysis–Genetics ; Computational Biology–Metabolism ; Gene Expression Regulation–Genetics ; Male–Genetics ; Metabolic Networks and Pathways–Genetics ; Micrornas–Genetics ; Muscle Development–Genetics ; RNA, Messenger–Genetics ; Transcriptome–Genetics ; Micrornas ; RNA, Messenger ; Barred Plymouth Rock ; Differential Expression ; Pedigree Male Broiler ; Production Efficiency ; Mirna
descriptionBACKGROUNDGenetically selected modern broiler chickens have acquired outstanding production efficiency through rapid growth and improved feed efficiency compared to unselected chicken breeds. Recently, we analyzed the transcriptome of breast muscle tissues obtained from modern pedigree male (PeM) broilers (rapid growth and higher efficiency) and foundational Barred Plymouth Rock (BPR) chickens (slow growth and poorer efficiency). This study was designed to investigate microRNAs that play role in rapid growth of the breast muscles in modern broiler chickens. RESULTSIn this study, differential abundance of microRNA (miRNA) was analyzed in breast muscle of PeM and BPR chickens and the results were integrated with differentially expressed (DE) mRNA in the same tissues. A total of 994 miRNA were identified in PeM and BPR chicken lines from the initial analysis of small RNA sequencing data. After filtering and statistical analyses, the results showed miR-2131-5p, miR-221-5p, miR-126-3p, miR-146b-5p, miR-10a-5p, let-7b, miR-125b-5p, and miR-146c-5p up-regulated whereas miR-206 down-regulated in PeM compared to BPR breast muscle. Based on inhibitory regulations of miRNAs on the mRNA abundance, our computational analysis using miRDB, an online software, predicated that 118 down-regulated mRNAs may be targeted by the up-regulated miRNAs, while 35 up-regulated mRNAs appear to be due to a down-regulated miRNA (i.e., miR-206). Functional network analyses of target genes of DE miRNAs showed their involvement in calcium signaling, axonal guidance signaling, and NRF2-mediated oxidative stress response pathways suggesting their involvement in breast muscle growth in chickens. CONCLUSIONFrom the integrated analyses of differentially expressed miRNA-mRNA data, we were able to identify breast muscle specific miRNAs and their target genes whose concerted actions can contribute to rapid growth and higher feed efficiency in modern broiler chickens. This study provides foundation data for elucidating molecular mechanisms that govern muscle growth in chickens.
languageeng
source
version8
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/2109333006/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Khatri, Bhuwan
1Seo, Dongwon
2Shouse, Stephanie
3Pan, Jeong Hoon
4Hudson, Nicholas J
5Kim, Jae Kyeom
6Bottje, Walter
7Kong, Byungwhi C
titleMicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.
descriptionBACKGROUNDGenetically selected modern broiler chickens have acquired outstanding production efficiency through rapid growth and improved feed efficiency compared to unselected chicken breeds. Recently, we analyzed the transcriptome of breast muscle tissues obtained from modern pedigree male (PeM) broilers (rapid growth and higher efficiency) and foundational Barred Plymouth Rock (BPR) chickens (slow growth and poorer efficiency). This study was designed to investigate microRNAs that play role in rapid growth of the breast muscles in modern broiler chickens. RESULTSIn this study, differential abundance of microRNA (miRNA) was analyzed in breast muscle of PeM and BPR chickens and the results were integrated with differentially expressed (DE) mRNA in the same tissues. A total of 994 miRNA were identified in PeM and BPR chicken lines from the initial analysis of small RNA sequencing data. After filtering and statistical analyses, the results showed miR-2131-5p, miR-221-5p, miR-126-3p, miR-146b-5p, miR-10a-5p, let-7b, miR-125b-5p, and miR-146c-5p up-regulated whereas miR-206 down-regulated in PeM compared to BPR breast muscle. Based on inhibitory regulations of miRNAs on the mRNA abundance, our computational analysis using miRDB, an online software, predicated that 118 down-regulated mRNAs may be targeted by the up-regulated miRNAs, while 35 up-regulated mRNAs appear to be due to a down-regulated miRNA (i.e., miR-206). Functional network analyses of target genes of DE miRNAs showed their involvement in calcium signaling, axonal guidance signaling, and NRF2-mediated oxidative stress response pathways suggesting their involvement in breast muscle growth in chickens. CONCLUSIONFrom the integrated analyses of differentially expressed miRNA-mRNA data, we were able to identify breast muscle specific miRNAs and their target genes whose concerted actions can contribute to rapid growth and higher feed efficiency in modern broiler chickens. This study provides foundation data for elucidating molecular mechanisms that govern muscle growth in chickens.
subject
0Animals–Growth & Development
1Breast–Genetics
2Breeding–Growth & Development
3Chickens–Classification
4Cluster Analysis–Genetics
5Computational Biology–Metabolism
6Gene Expression Regulation–Genetics
7Male–Genetics
8Metabolic Networks and Pathways–Genetics
9Micrornas–Genetics
10Muscle Development–Genetics
11RNA, Messenger–Genetics
12Transcriptome–Genetics
13Micrornas
14RNA, Messenger
15Barred Plymouth Rock
16Differential Expression
17Pedigree Male Broiler
18Production Efficiency
19Mirna
20Differential expression
21Pedigree male broiler
22Production efficiency
23miRNA
general
0English
11471-2164
210.1186/s12864-018-5061-7
3MEDLINE (ProQuest)
4ProQuest Biological Science Collection
5ProQuest Natural Science Collection
6ProQuest SciTech Collection
7Biological Science Database
8Natural Science Collection
9SciTech Premium Collection
10Health Research Premium Collection
11Health Research Premium Collection (Alumni edition)
sourceidproquest
recordidproquest2109333006
issn
014712164
11471-2164
rsrctypearticle
creationdate2018
addtitleBMC genomics
searchscope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
scope
01007527
11007944
210000004
310000038
410000050
510000120
610000159
710000238
810000253
910000260
1010000270
1110000271
1210000302
13proquest
lsr43
01007527false
11007944false
210000004false
310000038false
410000050false
510000120false
610000159false
710000238false
810000253false
910000260false
1010000270false
1110000271false
1210000302false
contributorKhatri, Bhuwan
startdate20180917
enddate20180917
citationpf 683 pt 683 vol 19 issue 1
lsr30VSR-Enriched:[pqid, galeid]
sort
titleMicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.
authorKhatri, Bhuwan ; Seo, Dongwon ; Shouse, Stephanie ; Pan, Jeong Hoon ; Hudson, Nicholas J ; Kim, Jae Kyeom ; Bottje, Walter ; Kong, Byungwhi C
creationdate20180917
lso0120180917
facets
frbrgroupid5328778546390098276
frbrtype5
newrecords20181218
languageeng
creationdate2018
topic
0Animals–Growth & Development
1Breast–Genetics
2Breeding–Growth & Development
3Chickens–Classification
4Cluster Analysis–Genetics
5Computational Biology–Metabolism
6Gene Expression Regulation–Genetics
7Male–Genetics
8Metabolic Networks and Pathways–Genetics
9Micrornas–Genetics
10Muscle Development–Genetics
11RNA, Messenger–Genetics
12Transcriptome–Genetics
13Micrornas
14RNA, Messenger
15Barred Plymouth Rock
16Differential Expression
17Pedigree Male Broiler
18Production Efficiency
19Mirna
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
prefilterarticles
rsrctypearticles
creatorcontrib
0Khatri, Bhuwan
1Seo, Dongwon
2Shouse, Stephanie
3Pan, Jeong Hoon
4Hudson, Nicholas J
5Kim, Jae Kyeom
6Bottje, Walter
7Kong, Byungwhi C
jtitleBMC genomics
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Khatri
1Seo
2Shouse
3Pan
4Hudson
5Kim
6Bottje
7Kong
aufirst
0Bhuwan
1Dongwon
2Stephanie
3Jeong Hoon
4Nicholas J
5Jae Kyeom
6Walter
7Byungwhi C
au
0Khatri, Bhuwan
1Seo, Dongwon
2Shouse, Stephanie
3Pan, Jeong Hoon
4Hudson, Nicholas J
5Kim, Jae Kyeom
6Bottje, Walter
7Kong, Byungwhi C
addauKhatri, Bhuwan
atitleMicroRNA profiling associated with muscle growth in modern broilers compared to an unselected chicken breed.
jtitleBMC genomics
risdate20180917
volume19
issue1
spage683
epage683
pages683
eissn1471-2164
formatjournal
genrearticle
ristypeJOUR
abstractBACKGROUNDGenetically selected modern broiler chickens have acquired outstanding production efficiency through rapid growth and improved feed efficiency compared to unselected chicken breeds. Recently, we analyzed the transcriptome of breast muscle tissues obtained from modern pedigree male (PeM) broilers (rapid growth and higher efficiency) and foundational Barred Plymouth Rock (BPR) chickens (slow growth and poorer efficiency). This study was designed to investigate microRNAs that play role in rapid growth of the breast muscles in modern broiler chickens. RESULTSIn this study, differential abundance of microRNA (miRNA) was analyzed in breast muscle of PeM and BPR chickens and the results were integrated with differentially expressed (DE) mRNA in the same tissues. A total of 994 miRNA were identified in PeM and BPR chicken lines from the initial analysis of small RNA sequencing data. After filtering and statistical analyses, the results showed miR-2131-5p, miR-221-5p, miR-126-3p, miR-146b-5p, miR-10a-5p, let-7b, miR-125b-5p, and miR-146c-5p up-regulated whereas miR-206 down-regulated in PeM compared to BPR breast muscle. Based on inhibitory regulations of miRNAs on the mRNA abundance, our computational analysis using miRDB, an online software, predicated that 118 down-regulated mRNAs may be targeted by the up-regulated miRNAs, while 35 up-regulated mRNAs appear to be due to a down-regulated miRNA (i.e., miR-206). Functional network analyses of target genes of DE miRNAs showed their involvement in calcium signaling, axonal guidance signaling, and NRF2-mediated oxidative stress response pathways suggesting their involvement in breast muscle growth in chickens. CONCLUSIONFrom the integrated analyses of differentially expressed miRNA-mRNA data, we were able to identify breast muscle specific miRNAs and their target genes whose concerted actions can contribute to rapid growth and higher feed efficiency in modern broiler chickens. This study provides foundation data for elucidating molecular mechanisms that govern muscle growth in chickens.
doi10.1186/s12864-018-5061-7
urlhttp://search.proquest.com/docview/2109333006/
date2018-09-17