schliessen

Filtern

 

Bibliotheken

Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.

OBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED tr... Full description

Journal Title: Diabetes care December 2018, Vol.41(12), pp.2617-2624
Main Author: Razquin, Cristina
Other Authors: Toledo, Estefanía , Clish, Clary B , Ruiz-Canela, Miguel , Dennis, Courtney , Corella, Dolores , Papandreou, Christopher , Ros, Emilio , Estruch, Ramon , Guasch-Ferré, Marta , Gómez-Gracia, Enrique , Fitó, Montserrat , Yu, Edward , Lapetra, José , Wang
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1935-5548 ; DOI: 10.2337/dc18-0840
Link: http://search.proquest.com/docview/2121491692/?pq-origsite=primo
Zum Text:
SendSend as email Add to Book BagAdd to Book Bag
Staff View
recordid: proquest2121491692
title: Plasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
format: Article
creator:
  • Razquin, Cristina
  • Toledo, Estefanía
  • Clish, Clary B
  • Ruiz-Canela, Miguel
  • Dennis, Courtney
  • Corella, Dolores
  • Papandreou, Christopher
  • Ros, Emilio
  • Estruch, Ramon
  • Guasch-Ferré, Marta
  • Gómez-Gracia, Enrique
  • Fitó, Montserrat
  • Yu, Edward
  • Lapetra, José
  • Wang
subjects:
  • Aged–Blood
  • Aged, 80 and Over–Epidemiology
  • Cardiovascular Diseases–Etiology
  • Case-Control Studies–Blood
  • Cohort Studies–Complications
  • Diabetes Mellitus, Type 2–Epidemiology
  • Female–Blood
  • Humans–Classification
  • Incidence–Classification
  • Lipid Metabolism–Classification
  • Lipids–Classification
  • Male–Classification
  • Metabolomics–Classification
  • Middle Aged–Classification
  • Risk Factors–Classification
  • Lipids
ispartof: Diabetes care, December 2018, Vol.41(12), pp.2617-2624
description: OBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of...
language: eng
source:
identifier: E-ISSN: 1935-5548 ; DOI: 10.2337/dc18-0840
fulltext: fulltext
issn:
  • 19355548
  • 1935-5548
url: Link


@attributes
ID725492766
RANK0.07
NO1
SEARCH_ENGINEprimo_central_multiple_fe
SEARCH_ENGINE_TYPEPrimo Central Search Engine
LOCALfalse
PrimoNMBib
record
control
sourcerecordid2121491692
sourceidproquest
recordidTN_proquest2121491692
sourcesystemPC
pqid2121491692
galeid568215813
display
typearticle
titlePlasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
creatorRazquin, Cristina ; Toledo, Estefanía ; Clish, Clary B ; Ruiz-Canela, Miguel ; Dennis, Courtney ; Corella, Dolores ; Papandreou, Christopher ; Ros, Emilio ; Estruch, Ramon ; Guasch-Ferré, Marta ; Gómez-Gracia, Enrique ; Fitó, Montserrat ; Yu, Edward ; Lapetra, José ; Wang
contributorRazquin, Cristina (correspondence author) ; Razquin, Cristina (record owner)
ispartofDiabetes care, December 2018, Vol.41(12), pp.2617-2624
identifierE-ISSN: 1935-5548 ; DOI: 10.2337/dc18-0840
subjectAged–Blood ; Aged, 80 and Over–Epidemiology ; Cardiovascular Diseases–Etiology ; Case-Control Studies–Blood ; Cohort Studies–Complications ; Diabetes Mellitus, Type 2–Epidemiology ; Female–Blood ; Humans–Classification ; Incidence–Classification ; Lipid Metabolism–Classification ; Lipids–Classification ; Male–Classification ; Metabolomics–Classification ; Middle Aged–Classification ; Risk Factors–Classification ; Lipids
descriptionOBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of...
languageeng
source
version7
lds50peer_reviewed
links
openurl$$Topenurl_article
openurlfulltext$$Topenurlfull_article
backlink$$Uhttp://search.proquest.com/docview/2121491692/?pq-origsite=primo$$EView_record_in_ProQuest_(subscribers_only)
search
creatorcontrib
0Razquin, Cristina
1Toledo, Estefanía
2Clish, Clary B
3Ruiz-Canela, Miguel
4Dennis, Courtney
5Corella, Dolores
6Papandreou, Christopher
7Ros, Emilio
8Estruch, Ramon
9Guasch-Ferré, Marta
10Gómez-Gracia, Enrique
11Fitó, Montserrat
12Yu, Edward
13Lapetra, José
14Wang, Dong
15Romaguera, Dora
16Liang, Liming
17Alonso-Gómez, Angel
18Deik, Amy
19Bullo, Mónica
20Serra-Majem, Lluis
21Salas-Salvadó, Jordi
22Hu, Frank B
23Martínez-González, Miguel A
titlePlasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
descriptionOBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of...
subject
0Aged–Blood
1Aged, 80 and Over–Epidemiology
2Cardiovascular Diseases–Etiology
3Case-Control Studies–Blood
4Cohort Studies–Complications
5Diabetes Mellitus, Type 2–Epidemiology
6Female–Blood
7Humans–Classification
8Incidence–Classification
9Lipid Metabolism–Classification
10Lipids–Classification
11Male–Classification
12Metabolomics–Classification
13Middle Aged–Classification
14Risk Factors–Classification
15Lipids
16ISRCTN35739639
17ISRCTN
general
0English
110.2337/dc18-0840
2MEDLINE (ProQuest)
3ProQuest Biological Science Collection
4ProQuest Natural Science Collection
5ProQuest SciTech Collection
6Biological Science Database
7Natural Science Collection
8SciTech Premium Collection
9Health Research Premium Collection
10Health Research Premium Collection (Alumni edition)
11Biological Science Index (ProQuest)
sourceidproquest
recordidproquest2121491692
issn
019355548
11935-5548
rsrctypearticle
creationdate2018
addtitleDiabetes care
searchscope
01000084
11007527
21007944
31009130
410000004
510000038
610000050
710000120
810000159
910000238
1010000253
1110000260
1210000270
1310000271
1410000302
1510000350
16proquest
scope
01000084
11007527
21007944
31009130
410000004
510000038
610000050
710000120
810000159
910000238
1010000253
1110000260
1210000270
1310000271
1410000302
1510000350
16proquest
lsr43
01000084false
11007527false
21007944false
31009130false
410000004false
510000038false
610000050false
710000120false
810000159false
910000238false
1010000253false
1110000260false
1210000270false
1310000271false
1410000302false
1510000350false
contributorRazquin, Cristina
startdate20181201
enddate20181201
citationpf 2617 pt 2624 vol 41 issue 12
lsr30VSR-Enriched:[galeid, issn, pqid]
sort
titlePlasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
authorRazquin, Cristina ; Toledo, Estefanía ; Clish, Clary B ; Ruiz-Canela, Miguel ; Dennis, Courtney ; Corella, Dolores ; Papandreou, Christopher ; Ros, Emilio ; Estruch, Ramon ; Guasch-Ferré, Marta ; Gómez-Gracia, Enrique ; Fitó, Montserrat ; Yu, Edward ; Lapetra, José ; Wang
creationdate20181201
lso0120181201
facets
frbrgroupid3027891619330134556
frbrtype5
newrecords20181218
languageeng
creationdate2018
topic
0Aged–Blood
1Aged, 80 and Over–Epidemiology
2Cardiovascular Diseases–Etiology
3Case-Control Studies–Blood
4Cohort Studies–Complications
5Diabetes Mellitus, Type 2–Epidemiology
6Female–Blood
7Humans–Classification
8Incidence–Classification
9Lipid Metabolism–Classification
10Lipids–Classification
11Male–Classification
12Metabolomics–Classification
13Middle Aged–Classification
14Risk Factors–Classification
15Lipids
collection
0MEDLINE (ProQuest)
1ProQuest Biological Science Collection
2ProQuest Natural Science Collection
3ProQuest SciTech Collection
4Biological Science Database
5Natural Science Collection
6SciTech Premium Collection
7Health Research Premium Collection
8Health Research Premium Collection (Alumni edition)
9Biological Science Index (ProQuest)
prefilterarticles
rsrctypearticles
creatorcontrib
0Razquin, Cristina
1Toledo, Estefanía
2Clish, Clary B
3Ruiz-Canela, Miguel
4Dennis, Courtney
5Corella, Dolores
6Papandreou, Christopher
7Ros, Emilio
8Estruch, Ramon
9Guasch-Ferré, Marta
10Gómez-Gracia, Enrique
11Fitó, Montserrat
12Yu, Edward
13Lapetra, José
14Wang, Dong
15Romaguera, Dora
16Liang, Liming
17Alonso-Gómez, Angel
18Deik, Amy
19Bullo, Mónica
20Serra-Majem, Lluis
21Salas-Salvadó, Jordi
22Hu, Frank B
23Martínez-González, Miguel A
jtitleDiabetes care
toplevelpeer_reviewed
delivery
delcategoryRemote Search Resource
fulltextfulltext
addata
aulast
0Razquin
1Toledo
2Clish
3Ruiz-Canela
4Dennis
5Corella
6Papandreou
7Ros
8Estruch
9Guasch-Ferré
10Gómez-Gracia
11Fitó
12Yu
13Lapetra
14Wang
15Romaguera
16Liang
17Alonso-Gómez
18Deik
19Bullo
20Serra-Majem
21Salas-Salvadó
22Hu
23Martínez-González
aufirst
0Cristina
1Estefanía
2Clary B
3Miguel
4Courtney
5Dolores
6Christopher
7Emilio
8Ramon
9Marta
10Enrique
11Montserrat
12Edward
13José
14Dong
15Dora
16Liming
17Angel
18Amy
19Mónica
20Lluis
21Jordi
22Frank B
23Miguel A
au
0Razquin, Cristina
1Toledo, Estefanía
2Clish, Clary B
3Ruiz-Canela, Miguel
4Dennis, Courtney
5Corella, Dolores
6Papandreou, Christopher
7Ros, Emilio
8Estruch, Ramon
9Guasch-Ferré, Marta
10Gómez-Gracia, Enrique
11Fitó, Montserrat
12Yu, Edward
13Lapetra, José
14Wang, Dong
15Romaguera, Dora
16Liang, Liming
17Alonso-Gómez, Angel
18Deik, Amy
19Bullo, Mónica
20Serra-Majem, Lluis
21Salas-Salvadó, Jordi
22Hu, Frank B
23Martínez-González, Miguel A
addauRazquin, Cristina
atitlePlasma Lipidomic Profiling and Risk of Type 2 Diabetes in the PREDIMED Trial.
jtitleDiabetes care
risdate20181201
volume41
issue12
spage2617
epage2624
pages2617-2624
eissn1935-5548
formatjournal
genrearticle
ristypeJOUR
abstractOBJECTIVESpecific lipid molecular changes leading to type 2 diabetes (T2D) are largely unknown. We assessed lipidome factors associated with future occurrence of T2D in a population at high cardiovascular risk. RESEARCH DESIGN AND METHODSWe conducted a case-cohort study nested within the PREDIMED trial, with 250 incident T2D cases diagnosed during 3.8 years of median follow-up, and a random sample of 692 participants (639 noncases and 53 overlapping cases) without T2D at baseline. We repeatedly measured 207 plasma known lipid metabolites at baseline and after 1 year of follow-up. We built combined factors of lipid species using principal component analysis and assessed the association between these lipid factors (or their 1-year changes) and T2D incidence. RESULTSBaseline lysophosphatidylcholines and lysophosphatidylethanolamines (lysophospholipids [LPs]), phosphatidylcholine-plasmalogens (PC-PLs), sphingomyelins (SMs), and cholesterol esters (CEs) were inversely associated with risk of...
doi10.2337/dc18-0840
urlhttp://search.proquest.com/docview/2121491692/
issn01495992
date2018-12-01