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Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.

Mitochondrial biogenesis is a key factor, which influences the function of skeletal muscle. Increasingly, flavonoids are reported to have the potential ability of regulating mitochondrial biogenesis. In this study, we investigated the effects of tangeretin, a polymethoxylated flavonoid isolated from... Full description

Journal Title: Journal of agricultural and food chemistry November 14, 2018, Vol.66(45), pp.11917-11925
Main Author: Kou, Guangning
Other Authors: Li, Zhenqing , Wu, Chao , Liu, Yang , Hu, Yan , Guo, Liya , Xu, Xiaoyu , Zhou, Zhiqin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5118 ; DOI: 10.1021/acs.jafc.8b04124
Link: http://search.proquest.com/docview/2126913664/?pq-origsite=primo
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title: Citrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
format: Article
creator:
  • Kou, Guangning
  • Li, Zhenqing
  • Wu, Chao
  • Liu, Yang
  • Hu, Yan
  • Guo, Liya
  • Xu, Xiaoyu
  • Zhou, Zhiqin
subjects:
  • Amp-Activated Protein Kinases–Genetics
  • Animals–Metabolism
  • Cell Differentiation–Drug Effects
  • Citrus–Chemistry
  • Flavones–Administration & Dosage
  • Male–Drug Effects
  • Mice–Metabolism
  • Mitochondria–Drug Effects
  • Muscle, Skeletal–Growth & Development
  • Myoblasts–Metabolism
  • Organelle Biogenesis–Cytology
  • Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha–Drug Effects
  • Physical Conditioning, Animal–Metabolism
  • Plant Extracts–Genetics
  • Plant Extracts–Metabolism
  • Plant Extracts–Administration & Dosage
  • Flavones
ispartof: Journal of agricultural and food chemistry, November 14, 2018, Vol.66(45), pp.11917-11925
description: Mitochondrial biogenesis is a key factor, which influences the function of skeletal muscle. Increasingly, flavonoids are reported to have the potential ability of regulating mitochondrial biogenesis. In this study, we investigated the effects of tangeretin, a polymethoxylated flavonoid isolated from mandarin fruits, on mitochondrial biogenesis and its underlying mechanisms. The tangeretin was obtained from the peel of "Dahongpao" tangerine by macroporous adsorptive resins combined with preparative-high performance liquid chromatography. The activity of mitochondrial biogenesis was explored by using mouse-derived C2C12 myoblasts and Kunming mice. Results showed that the purity of tangeretin obtained was 98.64%, and it could effectively activate mitochondrial biogenesis signaling pathway both at gene and at protein levels in C2C12 myoblasts. Animal experiments showed that tangeretin pretreatment could markedly improve exercise performance (the time of hanging wire and run to fatigue was obviously...
language: eng
source:
identifier: E-ISSN: 1520-5118 ; DOI: 10.1021/acs.jafc.8b04124
fulltext: fulltext
issn:
  • 15205118
  • 1520-5118
url: Link


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titleCitrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
creatorKou, Guangning ; Li, Zhenqing ; Wu, Chao ; Liu, Yang ; Hu, Yan ; Guo, Liya ; Xu, Xiaoyu ; Zhou, Zhiqin
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identifierE-ISSN: 1520-5118 ; DOI: 10.1021/acs.jafc.8b04124
subjectAmp-Activated Protein Kinases–Genetics ; Animals–Metabolism ; Cell Differentiation–Drug Effects ; Citrus–Chemistry ; Flavones–Administration & Dosage ; Male–Drug Effects ; Mice–Metabolism ; Mitochondria–Drug Effects ; Muscle, Skeletal–Growth & Development ; Myoblasts–Metabolism ; Organelle Biogenesis–Cytology ; Peroxisome Proliferator-Activated Receptor Gamma Coactivator 1-Alpha–Drug Effects ; Physical Conditioning, Animal–Metabolism ; Plant Extracts–Genetics ; Plant Extracts–Metabolism ; Plant Extracts–Administration & Dosage ; Flavones
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descriptionMitochondrial biogenesis is a key factor, which influences the function of skeletal muscle. Increasingly, flavonoids are reported to have the potential ability of regulating mitochondrial biogenesis. In this study, we investigated the effects of tangeretin, a polymethoxylated flavonoid isolated from mandarin fruits, on mitochondrial biogenesis and its underlying mechanisms. The tangeretin was obtained from the peel of "Dahongpao" tangerine by macroporous adsorptive resins combined with preparative-high performance liquid chromatography. The activity of mitochondrial biogenesis was explored by using mouse-derived C2C12 myoblasts and Kunming mice. Results showed that the purity of tangeretin obtained was 98.64%, and it could effectively activate mitochondrial biogenesis signaling pathway both at gene and at protein levels in C2C12 myoblasts. Animal experiments showed that tangeretin pretreatment could markedly improve exercise performance (the time of hanging wire and run to fatigue was obviously...
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titleCitrus Tangeretin Improves Skeletal Muscle Mitochondrial Biogenesis via Activating the AMPK-PGC1-α Pathway In Vitro and In Vivo: A Possible Mechanism for Its Beneficial Effect on Physical Performance.
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