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Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells.

Artemisia sacrorum Ledeb., a Compositae forage plant in China, has been found to have an inhibitory effect on lipid accumulation. We selected 12 flavonoids, which we had isolated from A. sacrorum and had the potential to inhibit lipid accumulation in the literature or in our preliminary experiments,... Full description

Journal Title: Journal of agricultural and food chemistry December 12, 2018, Vol.66(49), pp.12931-12940
Main Author: Ma, Qianqian
Other Authors: Cui, Yunlong , Xu, Siyuan , Zhao, Yiyao , Yuan, Haidan , Piao, Guangchun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1520-5118 ; DOI: 1520-5118 ; DOI: 10.1021/acs.jafc.8b04683
Link: http://search.proquest.com/docview/2127953597/?pq-origsite=primo
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title: Synergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells.
format: Article
creator:
  • Ma, Qianqian
  • Cui, Yunlong
  • Xu, Siyuan
  • Zhao, Yiyao
  • Yuan, Haidan
  • Piao, Guangchun
subjects:
  • 3t3-L1 Cells–Metabolism
  • Amp-Activated Protein Kinases–Drug Effects
  • Adipocytes–Metabolism
  • Animals–Physiology
  • Apigenin–Administration & Dosage
  • Artemisia–Chemistry
  • Cell Differentiation–Drug Effects
  • Cell Survival–Drug Effects
  • China–Administration & Dosage
  • Drug Synergism–Administration & Dosage
  • Flavones–Drug Effects
  • Flavonoids–Drug Effects
  • Lipid Metabolism–Analysis
  • Mice–Metabolism
  • Phosphorylation–Metabolism
  • Reproducibility of Results–Metabolism
  • Triglycerides–Metabolism
  • Flavones
  • Flavonoids
  • Triglycerides
  • Apigenin
  • Amp-Activated Protein Kinases
  • Acacetin
  • Amp-Activated Protein Kinase
  • Artemisia Sacrorum Ledeb.
  • Acacetin
  • Apigenin
  • Lipid Accumulation
  • Synergistic Effect
ispartof: Journal of agricultural and food chemistry, December 12, 2018, Vol.66(49), pp.12931-12940
description: Artemisia sacrorum Ledeb., a Compositae forage plant in China, has been found to have an inhibitory effect on lipid accumulation. We selected 12 flavonoids, which we had isolated from A. sacrorum and had the potential to inhibit lipid accumulation in the literature or in our preliminary experiments, and grouped them into 11 compound combinations; we investigated their synergistic inhibitory effects on lipid accumulation in 3T3-L1 cells. In screening experiments, Oil-Red O staining, triglyceride levels, and lipid accumulation levels all indicated that combined acacetin and apigenin displayed a significant synergistic inhibitory effect and the best repeatability. Subsequent research showed that this combination could synergistically promote the phosphorylations of AMPK and ACC. Furthermore, to a different extent, that combination had significant synergistic inhibitory effects on various genes or proteins related to adipogenesis and lipogenesis. Thus, that combination could significantly reduce triglyceride levels and lipid accumulation compared with acacetin or apigenin acting alone.
language: eng
source:
identifier: E-ISSN: 1520-5118 ; DOI: 1520-5118 ; DOI: 10.1021/acs.jafc.8b04683
fulltext: no_fulltext
issn:
  • 15205118
  • 1520-5118
url: Link


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titleSynergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells.
creatorMa, Qianqian ; Cui, Yunlong ; Xu, Siyuan ; Zhao, Yiyao ; Yuan, Haidan ; Piao, Guangchun
contributorMa, Qianqian (correspondence author) ; Ma, Qianqian (record owner)
ispartofJournal of agricultural and food chemistry, December 12, 2018, Vol.66(49), pp.12931-12940
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subject3t3-L1 Cells–Metabolism ; Amp-Activated Protein Kinases–Drug Effects ; Adipocytes–Metabolism ; Animals–Physiology ; Apigenin–Administration & Dosage ; Artemisia–Chemistry ; Cell Differentiation–Drug Effects ; Cell Survival–Drug Effects ; China–Administration & Dosage ; Drug Synergism–Administration & Dosage ; Flavones–Drug Effects ; Flavonoids–Drug Effects ; Lipid Metabolism–Analysis ; Mice–Metabolism ; Phosphorylation–Metabolism ; Reproducibility of Results–Metabolism ; Triglycerides–Metabolism ; Flavones ; Flavonoids ; Triglycerides ; Apigenin ; Amp-Activated Protein Kinases ; Acacetin ; Amp-Activated Protein Kinase ; Artemisia Sacrorum Ledeb. ; Acacetin ; Apigenin ; Lipid Accumulation ; Synergistic Effect
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descriptionArtemisia sacrorum Ledeb., a Compositae forage plant in China, has been found to have an inhibitory effect on lipid accumulation. We selected 12 flavonoids, which we had isolated from A. sacrorum and had the potential to inhibit lipid accumulation in the literature or in our preliminary experiments, and grouped them into 11 compound combinations; we investigated their synergistic inhibitory effects on lipid accumulation in 3T3-L1 cells. In screening experiments, Oil-Red O staining, triglyceride levels, and lipid accumulation levels all indicated that combined acacetin and apigenin displayed a significant synergistic inhibitory effect and the best repeatability. Subsequent research showed that this combination could synergistically promote the phosphorylations of AMPK and ACC. Furthermore, to a different extent, that combination had significant synergistic inhibitory effects on various genes or proteins related to adipogenesis and lipogenesis. Thus, that combination could significantly reduce triglyceride levels and lipid accumulation compared with acacetin or apigenin acting alone.
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titleSynergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells.
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03t3-L1 Cells–Metabolism
1Amp-Activated Protein Kinases–Drug Effects
2Adipocytes–Metabolism
3Animals–Physiology
4Apigenin–Administration & Dosage
5Artemisia–Chemistry
6Cell Differentiation–Drug Effects
7Cell Survival–Drug Effects
8China–Administration & Dosage
9Drug Synergism–Administration & Dosage
10Flavones–Drug Effects
11Flavonoids–Drug Effects
12Lipid Metabolism–Analysis
13Mice–Metabolism
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15Reproducibility of Results–Metabolism
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19Triglycerides
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21Amp-Activated Protein Kinases
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titleSynergistic Inhibitory Effects of Acacetin and 11 Other Flavonoids Isolated from Artemisia sacrorum on Lipid Accumulation in 3T3-L1 Cells.
authorMa, Qianqian ; Cui, Yunlong ; Xu, Siyuan ; Zhao, Yiyao ; Yuan, Haidan ; Piao, Guangchun
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03t3-L1 Cells–Metabolism
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