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Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.

BACKGROUNDEmerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expressio... Full description

Journal Title: Biological research November 3, 2018, Vol.51(1), p.44
Main Author: Song, Bin
Other Authors: Du, Juan , Song, De-Feng , Ren, Ji-Chen , Feng, Ye
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 0717-6287 ; DOI: 10.1186/s40659-018-0192-5
Link: http://search.proquest.com/docview/2130056080/?pq-origsite=primo
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title: Dysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.
format: Article
creator:
  • Song, Bin
  • Du, Juan
  • Song, De-Feng
  • Ren, Ji-Chen
  • Feng, Ye
subjects:
  • Biomarkers, Tumor–Genetics
  • Cell Cycle Proteins–Genetics
  • Disease Progression–Metabolism
  • Gene Expression Profiling–Genetics
  • Gene Expression Regulation, Neoplastic–Metabolism
  • Humans–Metabolism
  • Micrornas–Diagnosis
  • Microtubule-Associated Proteins–Genetics
  • Real-Time Polymerase Chain Reaction–Metabolism
  • Stomach Neoplasms–Genetics
  • Up-Regulation–Genetics
  • Biomarkers, Tumor
  • Casc5 Protein, Human
  • Cell Cycle Proteins
  • Mirn-1179 Microrna, Human
  • Mirn148 Microrna, Human
  • Mirn193 Microrna, Human
  • Micrornas
  • Microtubule-Associated Proteins
  • Ncapg Protein, Human
ispartof: Biological research, November 3, 2018, Vol.51(1), p.44
description: BACKGROUNDEmerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles. METHODSThe mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Then, targets genes of DE-miRNAs were predicted and the DE-miRNA-DEG regulatory network was constructed. Next, function enrichment analysis of the overlapped genes between the predicted DE-miRNAs targets and DEGs was performed and a protein-protein interactions network of overlapped genes was constructed. Finally, RT-PCR analysis was performed to detect the expression levels of several key DEGs and DE-miRNAs. RESULTSA set of 703 upregulated and 600 downregulated...
language: eng
source:
identifier: E-ISSN: 0717-6287 ; DOI: 10.1186/s40659-018-0192-5
fulltext: fulltext
issn:
  • 07176287
  • 0717-6287
url: Link


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titleDysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.
creatorSong, Bin ; Du, Juan ; Song, De-Feng ; Ren, Ji-Chen ; Feng, Ye
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ispartofBiological research, November 3, 2018, Vol.51(1), p.44
identifierE-ISSN: 0717-6287 ; DOI: 10.1186/s40659-018-0192-5
subjectBiomarkers, Tumor–Genetics ; Cell Cycle Proteins–Genetics ; Disease Progression–Metabolism ; Gene Expression Profiling–Genetics ; Gene Expression Regulation, Neoplastic–Metabolism ; Humans–Metabolism ; Micrornas–Diagnosis ; Microtubule-Associated Proteins–Genetics ; Real-Time Polymerase Chain Reaction–Metabolism ; Stomach Neoplasms–Genetics ; Up-Regulation–Genetics ; Biomarkers, Tumor ; Casc5 Protein, Human ; Cell Cycle Proteins ; Mirn-1179 Microrna, Human ; Mirn148 Microrna, Human ; Mirn193 Microrna, Human ; Micrornas ; Microtubule-Associated Proteins ; Ncapg Protein, Human
descriptionBACKGROUNDEmerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles. METHODSThe mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Then, targets genes of DE-miRNAs were predicted and the DE-miRNA-DEG regulatory network was constructed. Next, function enrichment analysis of the overlapped genes between the predicted DE-miRNAs targets and DEGs was performed and a protein-protein interactions network of overlapped genes was constructed. Finally, RT-PCR analysis was performed to detect the expression levels of several key DEGs and DE-miRNAs. RESULTSA set of 703 upregulated and 600 downregulated...
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titleDysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.
descriptionBACKGROUNDEmerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles. METHODSThe mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Then, targets genes of DE-miRNAs were predicted and the DE-miRNA-DEG regulatory network was constructed. Next, function enrichment analysis of the overlapped genes between the predicted DE-miRNAs targets and DEGs was performed and a protein-protein interactions network of overlapped genes was constructed. Finally, RT-PCR analysis was performed to detect the expression levels of several key DEGs and DE-miRNAs. RESULTSA set of 703 upregulated and 600 downregulated...
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titleDysregulation of NCAPG, KNL1, miR-148a-3p, miR-193b-3p, and miR-1179 may contribute to the progression of gastric cancer.
authorSong, Bin ; Du, Juan ; Song, De-Feng ; Ren, Ji-Chen ; Feng, Ye
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abstractBACKGROUNDEmerging evidence indicate that miRNAs play an important role on gastric cancer (GC) progression via regulating several downstream targets, but it is still partially uncovered. This study aimed to explore the molecular mechanisms of GC by comprehensive analysis of mRNAs and miRNA expression profiles. METHODSThe mRNA and miRNA expression profiles of GSE79973 and GSE67354 downloaded from Gene Expression Omnibus were used to analyze the differentially expressed genes (DEGs) and DE-miRNAs among GC tissues and normal tissues. Then, targets genes of DE-miRNAs were predicted and the DE-miRNA-DEG regulatory network was constructed. Next, function enrichment analysis of the overlapped genes between the predicted DE-miRNAs targets and DEGs was performed and a protein-protein interactions network of overlapped genes was constructed. Finally, RT-PCR analysis was performed to detect the expression levels of several key DEGs and DE-miRNAs. RESULTSA set of 703 upregulated and 600 downregulated...
doi10.1186/s40659-018-0192-5
urlhttp://search.proquest.com/docview/2130056080/
issn07169760
date2018-11-03