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Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines

Background Epithelial–mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We h... Full description

Journal Title: BMC Genomics 2018, Vol.19
Main Author: Yue-Ting, Tang
Other Authors: Yi-Yao, Huang , Jing-Huan, Li , Si-Hua, Qin , Xu, Yong , Tai-Xue, An , Chun-Chen, Liu , Wang, Qian , Zheng, Lei
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 14712164 ; DOI: 10.1186/s12864-018-5143-6
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title: Alterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines
format: Article
creator:
  • Yue-Ting, Tang
  • Yi-Yao, Huang
  • Jing-Huan, Li
  • Si-Hua, Qin
  • Xu, Yong
  • Tai-Xue, An
  • Chun-Chen, Liu
  • Wang, Qian
  • Zheng, Lei
subjects:
  • United States–Us
  • Glycoproteins
  • Metastasis
  • Cancer
  • Genomes
  • Cell Culture
  • Transduction
  • Lung Cancer
  • Phenotypes
  • Cell Lines
  • Micrornas
  • Cell Migration
  • Exosomes
  • Metastases
  • Genotype & Phenotype
  • Breast Cancer
  • Cell Cycle
  • Cell Culture
ispartof: BMC Genomics, 2018, Vol.19
description: Background Epithelial–mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We hypothesized that the miRNA profile of exosomes may change following EMT and these exosomal miRNAs may in return promote EMT, migration and invasion of cancer cells. Results The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. Co-culture experiments confirmed that M-exosomes can enter epithelial cells and promote migration, invasion and expression of mesenchymal markers in the recipient cells. Conclusion Our results reveal changes in the function and miRNA profile of exosomes upon EMT. M-exosomes...
language: eng
source:
identifier: E-ISSN: 14712164 ; DOI: 10.1186/s12864-018-5143-6
fulltext: fulltext_linktorsrc
issn:
  • 14712164
  • 1471-2164
url: Link


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titleAlterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines
creatorYue-Ting, Tang ; Yi-Yao, Huang ; Jing-Huan, Li ; Si-Hua, Qin ; Xu, Yong ; Tai-Xue, An ; Chun-Chen, Liu ; Wang, Qian ; Zheng, Lei
ispartofBMC Genomics, 2018, Vol.19
identifierE-ISSN: 14712164 ; DOI: 10.1186/s12864-018-5143-6
subjectUnited States–Us ; Glycoproteins ; Metastasis ; Cancer ; Genomes ; Cell Culture ; Transduction ; Lung Cancer ; Phenotypes ; Cell Lines ; Micrornas ; Cell Migration ; Exosomes ; Metastases ; Genotype & Phenotype ; Breast Cancer ; Cell Cycle ; Cell Culture
descriptionBackground Epithelial–mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We hypothesized that the miRNA profile of exosomes may change following EMT and these exosomal miRNAs may in return promote EMT, migration and invasion of cancer cells. Results The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. Co-culture experiments confirmed that M-exosomes can enter epithelial cells and promote migration, invasion and expression of mesenchymal markers in the recipient cells. Conclusion Our results reveal changes in the function and miRNA profile of exosomes upon EMT. M-exosomes...
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titleAlterations in exosomal miRNA profile upon epithelial-mesenchymal transition in human lung cancer cell lines
descriptionBackground Epithelial–mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We hypothesized that the miRNA profile of exosomes may change following EMT and these exosomal miRNAs may in return promote EMT, migration and invasion of cancer cells. Results The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. Co-culture experiments confirmed that M-exosomes can enter epithelial cells and promote migration, invasion and expression of mesenchymal markers in the recipient cells. Conclusion Our results reveal changes in the function and miRNA profile of exosomes upon EMT. M-exosomes...
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authorYue-Ting, Tang ; Yi-Yao, Huang ; Jing-Huan, Li ; Si-Hua, Qin ; Xu, Yong ; Tai-Xue, An ; Chun-Chen, Liu ; Wang, Qian ; Zheng, Lei
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abstractBackground Epithelial–mesenchymal transition (EMT) is regarded as a critical event during tumor metastasis. Recent studies have revealed changes and the contributions of proteins in/on exosomes during EMT. Besides proteins, microRNA (miRNA) is another important functional component of exosomes. We hypothesized that the miRNA profile of exosomes may change following EMT and these exosomal miRNAs may in return promote EMT, migration and invasion of cancer cells. Results The small RNA profile of exosomes was altered following EMT. Kyoto Encyclopedia of Genes and Genomes (KEGG) pathway analysis revealed that the specific miRNAs of M-exosomes have the potential to drive signal transduction networks in EMT and cancer progression. Co-culture experiments confirmed that M-exosomes can enter epithelial cells and promote migration, invasion and expression of mesenchymal markers in the recipient cells. Conclusion Our results reveal changes in the function and miRNA profile of exosomes upon EMT. M-exosomes...
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