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Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions

Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly unders... Full description

Journal Title: Journal of Neuroscience Research Apr 2019, Vol.97(4), pp.402-413
Main Author: Volgin, Andrey
Other Authors: Yakovlev, Oleg , Demin, Konstantin , de Abreu, Murilo , Alekseeva, Polina , Friend, Ashton , Lakstygal, Anton , Amstislavskaya, Tamara , Bao, Wandong , Cai, Song , Kalueff, Allan
Format: Electronic Article Electronic Article
Language: English
Subjects:
Sex
ID: ISSN: 03604012 ; E-ISSN: 10974547 ; DOI: 10.1002/jnr.24337
Link: http://search.proquest.com/docview/2176646776/?pq-origsite=primo
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title: Zebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
format: Article
creator:
  • Volgin, Andrey
  • Yakovlev, Oleg
  • Demin, Konstantin
  • de Abreu, Murilo
  • Alekseeva, Polina
  • Friend, Ashton
  • Lakstygal, Anton
  • Amstislavskaya, Tamara
  • Bao, Wandong
  • Cai, Song
  • Kalueff, Allan
subjects:
  • Danio Rerio
  • Gender Differences
  • Physiology
  • Gender Aspects
  • Sex Differences
  • Environment Models
  • Physiology
  • Psychiatry
  • Genetic Modification
  • Mental Disorders
  • Zebrafish
  • Homology
  • Genomes
  • Pharmacology
  • Molecular Modelling
  • Zebrafish
  • Sex
  • Environmental Factors
  • Animal Models
  • Psychiatry
  • Environmental Factors
  • Homology
  • Mental Disorders
  • Gene–Environment Interactions
  • Individual Differences
  • Personalized Psychiatry
  • Zebrafish
ispartof: Journal of Neuroscience Research, Apr 2019, Vol.97(4), pp.402-413
description: Currently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient‐centered personalized psychiatry.
language: eng
source:
identifier: ISSN: 03604012 ; E-ISSN: 10974547 ; DOI: 10.1002/jnr.24337
fulltext: fulltext
issn:
  • 03604012
  • 0360-4012
  • 10974547
  • 1097-4547
url: Link


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titleZebrafish models for personalized psychiatry: Insights from individual, strain and sex differences, and modeling gene x environment interactions
creatorVolgin, Andrey ; Yakovlev, Oleg ; Demin, Konstantin ; de Abreu, Murilo ; Alekseeva, Polina ; Friend, Ashton ; Lakstygal, Anton ; Amstislavskaya, Tamara ; Bao, Wandong ; Cai, Song ; Kalueff, Allan
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subjectDanio Rerio ; Gender Differences ; Physiology ; Gender Aspects ; Sex Differences ; Environment Models ; Physiology ; Psychiatry ; Genetic Modification ; Mental Disorders ; Zebrafish ; Homology ; Genomes ; Pharmacology ; Molecular Modelling ; Zebrafish ; Sex ; Environmental Factors ; Animal Models ; Psychiatry ; Environmental Factors ; Homology ; Mental Disorders ; Gene–Environment Interactions ; Individual Differences ; Personalized Psychiatry ; Zebrafish
descriptionCurrently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient‐centered personalized psychiatry.
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abstractCurrently becoming widely recognized, personalized psychiatry focuses on unique physiological and genetic profiles of patients to best tailor their therapy. However, the role of individual differences, as well as genetic and environmental factors, in human psychiatric disorders remains poorly understood. Animal experimental models are a valuable tool to improve our understanding of disease pathophysiology and its molecular mechanisms. Due to high reproduction capability, fully sequenced genome, easy gene editing, and high genetic and physiological homology with humans, zebrafish (Danio rerio) are emerging as a novel powerful model in biomedicine. Mounting evidence supports zebrafish as a useful model organism in CNS research. Robustly expressed in these fish, individual, strain, and sex differences shape their CNS responses to genetic, environmental, and pharmacological manipulations. Here, we discuss zebrafish as a promising complementary translational tool to further advance patient‐centered personalized psychiatry.
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date2019-04-01