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Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats

We previously reported that intrathecal pro-opiomelanocortin gene electroporation could reduce pain sensitivity induced by chronic constriction injury (CCI) of the sciatic nerve. For optimal use of antinociceptive gene therapy, it might be important to...

Journal Title: Gene Therapy Jun 2004, Vol.11(11), pp.933-40
Main Author: C-M, Wu
Other Authors: M-W, Lin , J-T, Cheng , Y-M, Wang , Y-W, Huang , C-R, Lin
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3302244
Link: http://search.proquest.com/docview/218672236/?pq-origsite=primo
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title: Regulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats
format: Article
creator:
  • C-M, Wu
  • M-W, Lin
  • J-T, Cheng
  • Y-M, Wang
  • Y-W, Huang
  • C-R, Lin
subjects:
  • Analgesia–Methods
  • Animals–Administration & Dosage
  • Anti-Bacterial Agents–Administration & Dosage
  • Cells, Cultured–Administration & Dosage
  • DNA–Methods
  • Doxycycline–Methods
  • Electroporation–Metabolism
  • Gene Expression Regulation–Genetics
  • Genetic Therapy–Metabolism
  • Injections, Intraperitoneal–Complications
  • Neurons, Afferent–Physiopathology
  • Pro-Opiomelanocortin–Methods
  • Pro-Opiomelanocortin–Genetics
  • Rats–Secretion
  • Rats, Inbred Strains–Secretion
  • Spinal Cord Injuries–Secretion
  • Spinal Cord Injuries
ispartof: Gene Therapy, Jun 2004, Vol.11(11), pp.933-40
description: We previously reported that intrathecal pro-opiomelanocortin gene electroporation could reduce pain sensitivity induced by chronic constriction injury (CCI) of the sciatic nerve. For optimal use of antinociceptive gene therapy, it might be important to...
language: eng
source:
identifier: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3302244
fulltext: fulltext
issn:
  • 09697128
  • 0969-7128
  • 14765462
  • 1476-5462
url: Link


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titleRegulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats
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subjectAnalgesia–Methods ; Animals–Administration & Dosage ; Anti-Bacterial Agents–Administration & Dosage ; Cells, Cultured–Administration & Dosage ; DNA–Methods ; Doxycycline–Methods ; Electroporation–Metabolism ; Gene Expression Regulation–Genetics ; Genetic Therapy–Metabolism ; Injections, Intraperitoneal–Complications ; Neurons, Afferent–Physiopathology ; Pro-Opiomelanocortin–Methods ; Pro-Opiomelanocortin–Genetics ; Rats–Secretion ; Rats, Inbred Strains–Secretion ; Spinal Cord Injuries–Secretion ; Spinal Cord Injuries
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titleRegulated, electroporation-mediated delivery of pro-opiomelanocortin gene suppresses chronic constriction injury-induced neuropathic pain in rats
authorC-M, Wu ; M-W, Lin ; J-T, Cheng ; Y-M, Wang ; Y-W, Huang ; C-R, Lin
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abstractWe previously reported that intrathecal pro-opiomelanocortin gene electroporation could reduce pain sensitivity induced by chronic constriction injury (CCI) of the sciatic nerve. For optimal use of antinociceptive gene therapy, it might be important to...
copHoundmills
pubNature Publishing Group
doi10.1038/sj.gt.3302244
urlhttp://search.proquest.com/docview/218672236/
date2004-06-01