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Gene therapy progress and prospects: non-viral gene therapy by systemic delivery

Non-viral vectors continue to be an attractive alternative to viral vectors due to their safety, versatility and ease of preparation and scale-up. Over the past few years, investigators have been successful in developing gene carriers that can be targeted to the disease site. Several different deliv... Full description

Journal Title: Gene Therapy Sep 2006, pp.1313-9
Main Author: S-D, Li
Other Authors: Huang, L
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
ID: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3302838
Link: http://search.proquest.com/docview/218708636/?pq-origsite=primo
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recordid: proquest218708636
title: Gene therapy progress and prospects: non-viral gene therapy by systemic delivery
format: Article
creator:
  • S-D, Li
  • Huang, L
subjects:
  • DNA–Administration & Dosage
  • Forecasting–Methods
  • Gene Targeting–Trends
  • Genetic Therapy–Administration & Dosage
  • Genetic Therapy–Administration & Dosage
  • Genetic Vectors–Therapy
  • Humans–Methods
  • Injections–Trends
  • Liposomes–Trends
  • Neoplasms–Trends
  • RNA Interference–Trends
  • Transfection–Trends
  • Transfection–Trends
  • Gene Therapy
  • Ribonucleic Acid
  • Pharmacology
  • Toxicity
  • Deoxyribonucleic Acid
  • Deoxyribonucleic Acid–DNA
  • Ribonucleic Acid–RNA
  • Liposomes
  • DNA
ispartof: Gene Therapy, Sep 2006, pp.1313-9
description: Non-viral vectors continue to be an attractive alternative to viral vectors due to their safety, versatility and ease of preparation and scale-up. Over the past few years, investigators have been successful in developing gene carriers that can be targeted to the disease site. Several different delivery vectors for systemic use have been developed by different groups for plasmid DNA and oligonucleotide. Most of them are designed for targeted tumor therapy. The mechanism of inflammatory toxicity, the major toxicity of cationic lipoplex, has been studied and managed. In this review, we focus on the progress made over the last 2 years. We also discuss some future prospects for gene delivery.
language: eng
source:
identifier: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3302838
fulltext: fulltext
issn:
  • 09697128
  • 0969-7128
  • 14765462
  • 1476-5462
url: Link


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subjectDNA–Administration & Dosage ; Forecasting–Methods ; Gene Targeting–Trends ; Genetic Therapy–Administration & Dosage ; Genetic Therapy–Administration & Dosage ; Genetic Vectors–Therapy ; Humans–Methods ; Injections–Trends ; Liposomes–Trends ; Neoplasms–Trends ; RNA Interference–Trends ; Transfection–Trends ; Transfection–Trends ; Gene Therapy ; Ribonucleic Acid ; Pharmacology ; Toxicity ; Deoxyribonucleic Acid ; Deoxyribonucleic Acid–DNA ; Ribonucleic Acid–RNA ; Liposomes ; DNA
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abstractNon-viral vectors continue to be an attractive alternative to viral vectors due to their safety, versatility and ease of preparation and scale-up. Over the past few years, investigators have been successful in developing gene carriers that can be targeted to the disease site. Several different delivery vectors for systemic use have been developed by different groups for plasmid DNA and oligonucleotide. Most of them are designed for targeted tumor therapy. The mechanism of inflammatory toxicity, the major toxicity of cationic lipoplex, has been studied and managed. In this review, we focus on the progress made over the last 2 years. We also discuss some future prospects for gene delivery.
copHoundmills
pubNature Publishing Group
doi10.1038/sj.gt.3302838
urlhttp://search.proquest.com/docview/218708636/
volume13
issue18
date2006-09-01