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Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent

It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinoc... Full description

Journal Title: Gene Therapy Dec 2001, pp.1777-84
Main Author: Jeschke, M
Other Authors: Richter, G , Herndon, D , Geissler, E , Hartl, M , Hofstätter, F , Perez-Polo, J
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3301589
Link: http://search.proquest.com/docview/218710260/?pq-origsite=primo
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title: Therapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent
format: Article
creator:
  • Jeschke, M
  • Richter, G
  • Herndon, D
  • Geissler, E
  • Hartl, M
  • Hofstätter, F
  • Perez-Polo, J
subjects:
  • Animals–Metabolism
  • Apoptosis–Pathology
  • Burns–Therapy
  • Burns–Metabolism
  • Burns–Genetics
  • Cell Division–Genetics
  • Collagen–Metabolism
  • DNA, Complementary–Methods
  • Dose-Response Relationship, Drug–Genetics
  • Fibroblast Growth Factor 7–Metabolism
  • Fibroblast Growth Factors–Metabolism
  • Fibroblast Growth Factors–Pathology
  • Gene Transfer Techniques–Pathology
  • Genetic Therapy–Pathology
  • Insulin-Like Growth Factor I–Pathology
  • Insulin-Like Growth Factor I–Pathology
  • Liposomes–Pathology
  • Male–Pathology
  • Rats–Pathology
  • Rats, Sprague-Dawley–Pathology
  • Skin–Pathology
  • Skin–Pathology
  • Transfection–Pathology
  • Wound Healing–Pathology
  • DNA, Complementary
  • Fgf7 Protein, Rat
  • Liposomes
  • Fibroblast Growth Factor 7
  • Fibroblast Growth Factors
  • Insulin-Like Growth Factor I
  • Collagen
ispartof: Gene Therapy, Dec 2001, pp.1777-84
description: It is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinocyte...
language: eng
source:
identifier: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3301589
fulltext: fulltext
issn:
  • 09697128
  • 0969-7128
  • 14765462
  • 1476-5462
url: Link


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titleTherapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent
creatorJeschke, M ; Richter, G ; Herndon, D ; Geissler, E ; Hartl, M ; Hofstätter, F ; Perez-Polo, J
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subjectAnimals–Metabolism ; Apoptosis–Pathology ; Burns–Therapy ; Burns–Metabolism ; Burns–Genetics ; Cell Division–Genetics ; Collagen–Metabolism ; DNA, Complementary–Methods ; Dose-Response Relationship, Drug–Genetics ; Fibroblast Growth Factor 7–Metabolism ; Fibroblast Growth Factors–Metabolism ; Fibroblast Growth Factors–Pathology ; Gene Transfer Techniques–Pathology ; Genetic Therapy–Pathology ; Insulin-Like Growth Factor I–Pathology ; Insulin-Like Growth Factor I–Pathology ; Liposomes–Pathology ; Male–Pathology ; Rats–Pathology ; Rats, Sprague-Dawley–Pathology ; Skin–Pathology ; Skin–Pathology ; Transfection–Pathology ; Wound Healing–Pathology ; DNA, Complementary ; Fgf7 Protein, Rat ; Liposomes ; Fibroblast Growth Factor 7 ; Fibroblast Growth Factors ; Insulin-Like Growth Factor I ; Collagen
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titleTherapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent
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titleTherapeutic success and efficacy of nonviral liposomal cDNA gene transfer to the skin in vivo is dose dependent
authorJeschke, M ; Richter, G ; Herndon, D ; Geissler, E ; Hartl, M ; Hofstätter, F ; Perez-Polo, J
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abstractIt is well documented that responses to growth factor treatment typically display bell-shaped dose responses that can significantly affect efficacy. Here we tested the hypothesis that nonviral liposomal gene delivery also displays this characteristic. We chose two different growth factors, keratinocyte...
copHoundmills
pubNature Publishing Group
doi10.1038/sj.gt.3301589
urlhttp://search.proquest.com/docview/218710260/
issue23
volume8
date2001-12-01