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Gene therapy in wound healing: present status and future directions

Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especi... Full description

Journal Title: Gene Therapy Jan 2007, Vol.14(1), pp.1-10
Main Author: Branski, L
Other Authors: Pereira, C , Herndon, D , Jeschke, M
Format: Electronic Article Electronic Article
Language: English
Subjects:
DNA
DNA
ID: ISSN: 09697128 ; DOI: 10.1038/sj.gt.3302837
Link: http://search.proquest.com/docview/218713106/?pq-origsite=primo
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title: Gene therapy in wound healing: present status and future directions
format: Article
creator:
  • Branski, L
  • Pereira, C
  • Herndon, D
  • Jeschke, M
subjects:
  • Animals–Metabolism
  • Burns–Therapy
  • Burns–Administration & Dosage
  • DNA–Methods
  • Electroporation–Trends
  • Genetic Therapy–Administration & Dosage
  • Genetic Therapy–Genetics
  • Genetic Vectors–Physiology
  • Humans–Administration & Dosage
  • Intercellular Signaling Peptides & Proteins–Injuries
  • Intercellular Signaling Peptides & Proteins–Metabolism
  • Liposomes–Methods
  • Skin–Genetics
  • Skin–Genetics
  • Transfection–Metabolism
  • Viruses–Therapy
  • Wound Healing–Therapy
  • Wound Healing–Therapy
  • Wounds & Injuries–Therapy
  • Wounds & Injuries–Therapy
  • Gene Therapy
  • Wound Healing
  • Congenital Diseases
  • Skin
  • Deoxyribonucleic Acid
  • DNA
  • Models
  • Intercellular Signaling Peptides and Proteins
  • Liposomes
  • DNA
ispartof: Gene Therapy, Jan 2007, Vol.14(1), pp.1-10
description: Gene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.
language: eng
source:
identifier: ISSN: 09697128 ; DOI: 10.1038/sj.gt.3302837
fulltext: fulltext
issn:
  • 09697128
  • 0969-7128
url: Link


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descriptionGene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.
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titleGene therapy in wound healing: present status and future directions
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abstractGene therapy was traditionally considered a treatment modality for patients with congenital defects of key metabolic functions or late-stage malignancies. The realization that gene therapy applications were much vaster has opened up endless opportunities for therapeutic genetic manipulations, especially in the skin and external wounds. Cutaneous wound healing is a complicated, multistep process with numerous mediators that act in a network of activation and inhibition processes. Gene delivery in this environment poses a particular challenge. Numerous models of gene delivery have been developed, including naked DNA application, viral transfection, high-pressure injection, liposomal delivery, and more. Of the various methods for gene transfer, cationic cholesterol-containing liposomal constructs are emerging as a method with great potential for non-viral gene transfer in the wound. This article aims to review the research on gene therapy in wound healing and possible future directions in this exciting field.
copHoundmills
pubNature Publishing Group
doi10.1038/sj.gt.3302837
urlhttp://search.proquest.com/docview/218713106/
eissn14765462
date2007-01-01