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Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors

A folate-targeted, cationic lipid based transfection complex was developed and found to specifically transfect folate receptor-expressing cells and tumors. These liposomal vectors were comprised of protamine-condensed plasmid DNA, a mixture of cationic...

Journal Title: Gene Therapy Nov 2002, pp.1542-50
Main Author: Reddy, J
Other Authors: Abburi, C , Hofland, H , Howard, S , Vlahov, I , Wils, P , Leamon, C
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3301833
Link: http://search.proquest.com/docview/218715546/?pq-origsite=primo
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recordid: proquest218715546
title: Folate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors
format: Article
creator:
  • Reddy, J
  • Abburi, C
  • Hofland, H
  • Howard, S
  • Vlahov, I
  • Wils, P
  • Leamon, C
subjects:
  • Animals–Metabolism
  • Carrier Proteins–Genetics
  • Cell Line–Metabolism
  • Female–Methods
  • Folate Receptors, Gpi-Anchored–Methods
  • Folic Acid–Genetics
  • Folic Acid–Metabolism
  • Gene Targeting–Therapy
  • Genetic Therapy–Methods
  • Liposomes–Methods
  • Luciferases–Methods
  • Mice–Methods
  • Mice, Inbred Dba–Methods
  • Peritoneal Neoplasms–Methods
  • Peritoneal Neoplasms–Methods
  • Protein Binding–Methods
  • Receptors, Cell Surface–Methods
  • Transfection–Methods
  • Carrier Proteins
  • Folate Receptors, Gpi-Anchored
  • Liposomes
  • Receptors, Cell Surface
  • Folic Acid
  • Luciferases
ispartof: Gene Therapy, Nov 2002, pp.1542-50
description: A folate-targeted, cationic lipid based transfection complex was developed and found to specifically transfect folate receptor-expressing cells and tumors. These liposomal vectors were comprised of protamine-condensed plasmid DNA, a mixture of cationic...
language: eng
source:
identifier: ISSN: 09697128 ; E-ISSN: 14765462 ; DOI: 10.1038/sj.gt.3301833
fulltext: fulltext
issn:
  • 09697128
  • 0969-7128
  • 14765462
  • 1476-5462
url: Link


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subjectAnimals–Metabolism ; Carrier Proteins–Genetics ; Cell Line–Metabolism ; Female–Methods ; Folate Receptors, Gpi-Anchored–Methods ; Folic Acid–Genetics ; Folic Acid–Metabolism ; Gene Targeting–Therapy ; Genetic Therapy–Methods ; Liposomes–Methods ; Luciferases–Methods ; Mice–Methods ; Mice, Inbred Dba–Methods ; Peritoneal Neoplasms–Methods ; Peritoneal Neoplasms–Methods ; Protein Binding–Methods ; Receptors, Cell Surface–Methods ; Transfection–Methods ; Carrier Proteins ; Folate Receptors, Gpi-Anchored ; Liposomes ; Receptors, Cell Surface ; Folic Acid ; Luciferases
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titleFolate-targeted, cationic liposome-mediated gene transfer into disseminated peritoneal tumors
authorReddy, J ; Abburi, C ; Hofland, H ; Howard, S ; Vlahov, I ; Wils, P ; Leamon, C
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abstractA folate-targeted, cationic lipid based transfection complex was developed and found to specifically transfect folate receptor-expressing cells and tumors. These liposomal vectors were comprised of protamine-condensed plasmid DNA, a mixture of cationic...
copHoundmills
pubNature Publishing Group
doi10.1038/sj.gt.3301833
urlhttp://search.proquest.com/docview/218715546/
issue22
volume9
date2002-11-01