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Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.

BACKGROUNDMyeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partial... Full description

Journal Title: Molecular cancer March 30, 2019, Vol.18(1), p.61
Main Author: Zheng, Yu
Other Authors: Tian, Xinyu , Wang, Tingting , Xia, Xueli , Cao, Fenghua , Tian, Jie , Xu, Ping , Ma, Jie , Xu, Huaxi , Wang, Shengjun
Format: Electronic Article Electronic Article
Language: English
Subjects:
ID: E-ISSN: 1476-4598 ; DOI: 1476-4598 ; DOI: 10.1186/s12943-019-0978-2
Link: http://search.proquest.com/docview/2200784110/?pq-origsite=primo
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title: Long noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.
format: Article
creator:
  • Zheng, Yu
  • Tian, Xinyu
  • Wang, Tingting
  • Xia, Xueli
  • Cao, Fenghua
  • Tian, Jie
  • Xu, Ping
  • Ma, Jie
  • Xu, Huaxi
  • Wang, Shengjun
subjects:
  • Animals–Genetics
  • Apoptosis–Immunology
  • Carcinoma, Lewis Lung–Pathology
  • Cell Differentiation–Immunology
  • Cell Proliferation–Metabolism
  • Gene Expression Regulation, Neoplastic–Pathology
  • Granulocytes–Immunology
  • Male–Metabolism
  • Mice–Pathology
  • Mice, Inbred C57bl–Genetics
  • Myeloid-Derived Suppressor Cells–Genetics
  • RNA, Long Noncoding–Genetics
  • Tumor Cells, Cultured–Genetics
  • Pvt1 Long-Non-Coding RNA, Mouse
  • RNA, Long Noncoding
  • Immunosuppression
  • Long Noncoding RNA
  • Myeloid-Derived Suppressor Cells
  • Pvt1
ispartof: Molecular cancer, March 30, 2019, Vol.18(1), p.61
description: BACKGROUNDMyeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partially restore antitumor immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene in a variety of cancer types. However, whether lncRNA Pvt1 is involved in the regulation of MDSCs has not been thoroughly elucidated to date. METHODSMDSCs or granulocytic MDSCs (G-MDSCs) were isolated by microbeads and flow cytometry. Bone marrow derived G-MDSCs were induced by IL-6 and GM-CSF. The expression of lncRNA Pvt1 was measured by qRT-PCR. Specific siRNA was used to knockdown the expression of lncRNA Pvt1 in G-MDSCs. RESULTSIn this study, we found that knockdown of lncRNA Pvt1 significantly inhibited the immunosuppressive function of G-MDSCs in vitro. Additionally, lncRNA Pvt1 knockdown reduced the ability of G-MDSCs to delay tumor progression in tumor-bearing mice in vivo. Notably, lncRNA Pvt1 was upregulated by HIF-1α under hypoxia in G-MDSCs. CONCLUSIONSTaken together, our results demonstrate a critical role for lncRNA Pvt1 in regulating the immunosuppression activity of G-MDSCs, and lncRNA Pvt1 might thus be a potential antitumor immunotherapy target.
language: eng
source:
identifier: E-ISSN: 1476-4598 ; DOI: 1476-4598 ; DOI: 10.1186/s12943-019-0978-2
fulltext: fulltext
issn:
  • 14764598
  • 1476-4598
url: Link


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titleLong noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.
creatorZheng, Yu ; Tian, Xinyu ; Wang, Tingting ; Xia, Xueli ; Cao, Fenghua ; Tian, Jie ; Xu, Ping ; Ma, Jie ; Xu, Huaxi ; Wang, Shengjun
contributorZheng, Yu (correspondence author) ; Zheng, Yu (record owner)
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subjectAnimals–Genetics ; Apoptosis–Immunology ; Carcinoma, Lewis Lung–Pathology ; Cell Differentiation–Immunology ; Cell Proliferation–Metabolism ; Gene Expression Regulation, Neoplastic–Pathology ; Granulocytes–Immunology ; Male–Metabolism ; Mice–Pathology ; Mice, Inbred C57bl–Genetics ; Myeloid-Derived Suppressor Cells–Genetics ; RNA, Long Noncoding–Genetics ; Tumor Cells, Cultured–Genetics ; Pvt1 Long-Non-Coding RNA, Mouse ; RNA, Long Noncoding ; Immunosuppression ; Long Noncoding RNA ; Myeloid-Derived Suppressor Cells ; Pvt1
descriptionBACKGROUNDMyeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partially restore antitumor immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene in a variety of cancer types. However, whether lncRNA Pvt1 is involved in the regulation of MDSCs has not been thoroughly elucidated to date. METHODSMDSCs or granulocytic MDSCs (G-MDSCs) were isolated by microbeads and flow cytometry. Bone marrow derived G-MDSCs were induced by IL-6 and GM-CSF. The expression of lncRNA Pvt1 was measured by qRT-PCR. Specific siRNA was used to knockdown the expression of lncRNA Pvt1 in G-MDSCs. RESULTSIn this study, we found that knockdown of lncRNA Pvt1 significantly inhibited the immunosuppressive function of G-MDSCs in vitro. Additionally, lncRNA Pvt1 knockdown reduced the ability of G-MDSCs to delay tumor progression in tumor-bearing mice in vivo. Notably, lncRNA Pvt1 was upregulated by HIF-1α under hypoxia in G-MDSCs. CONCLUSIONSTaken together, our results demonstrate a critical role for lncRNA Pvt1 in regulating the immunosuppression activity of G-MDSCs, and lncRNA Pvt1 might thus be a potential antitumor immunotherapy target.
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titleLong noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.
descriptionBACKGROUNDMyeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partially restore antitumor immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene in a variety of cancer types. However, whether lncRNA Pvt1 is involved in the regulation of MDSCs has not been thoroughly elucidated to date. METHODSMDSCs or granulocytic MDSCs (G-MDSCs) were isolated by microbeads and flow cytometry. Bone marrow derived G-MDSCs were induced by IL-6 and GM-CSF. The expression of lncRNA Pvt1 was measured by qRT-PCR. Specific siRNA was used to knockdown the expression of lncRNA Pvt1 in G-MDSCs. RESULTSIn this study, we found that knockdown of lncRNA Pvt1 significantly inhibited the immunosuppressive function of G-MDSCs in vitro. Additionally, lncRNA Pvt1 knockdown reduced the ability of G-MDSCs to delay tumor progression in tumor-bearing mice in vivo. Notably, lncRNA Pvt1 was upregulated by HIF-1α under hypoxia in G-MDSCs. CONCLUSIONSTaken together, our results demonstrate a critical role for lncRNA Pvt1 in regulating the immunosuppression activity of G-MDSCs, and lncRNA Pvt1 might thus be a potential antitumor immunotherapy target.
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titleLong noncoding RNA Pvt1 regulates the immunosuppression activity of granulocytic myeloid-derived suppressor cells in tumor-bearing mice.
authorZheng, Yu ; Tian, Xinyu ; Wang, Tingting ; Xia, Xueli ; Cao, Fenghua ; Tian, Jie ; Xu, Ping ; Ma, Jie ; Xu, Huaxi ; Wang, Shengjun
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abstractBACKGROUNDMyeloid-derived suppressor cells (MDSCs) participate in tumor-elicited immunosuppression by dramatically blocking T-cell-induced antitumor responses, thereby influencing the effectiveness of cancer immunotherapies. Treatments that alter the differentiation and function of MDSCs can partially restore antitumor immune responses. The long noncoding RNA plasmacytoma variant translocation 1 (lncRNA Pvt1) is a potential oncogene in a variety of cancer types. However, whether lncRNA Pvt1 is involved in the regulation of MDSCs has not been thoroughly elucidated to date. METHODSMDSCs or granulocytic MDSCs (G-MDSCs) were isolated by microbeads and flow cytometry. Bone marrow derived G-MDSCs were induced by IL-6 and GM-CSF. The expression of lncRNA Pvt1 was measured by qRT-PCR. Specific siRNA was used to knockdown the expression of lncRNA Pvt1 in G-MDSCs. RESULTSIn this study, we found that knockdown of lncRNA Pvt1 significantly inhibited the immunosuppressive function of G-MDSCs in vitro. Additionally, lncRNA Pvt1 knockdown reduced the ability of G-MDSCs to delay tumor progression in tumor-bearing mice in vivo. Notably, lncRNA Pvt1 was upregulated by HIF-1α under hypoxia in G-MDSCs. CONCLUSIONSTaken together, our results demonstrate a critical role for lncRNA Pvt1 in regulating the immunosuppression activity of G-MDSCs, and lncRNA Pvt1 might thus be a potential antitumor immunotherapy target.
doi10.1186/s12943-019-0978-2
urlhttp://search.proquest.com/docview/2200784110/
orcidid0000-0001-6584-1183
date2019-03-30